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‫الرحمن‬ ‫هللا‬ ‫بسم‬
‫الرحيم‬
Head and Neck of 4-Week Old Embryo
EMBRYOLOGY
In 4-week old 5 mesenchymal
prominence can be recognized :
1. Unpaired Frontonasal Prominence
2. Medial and Lateral Nasal
prominences
3. 2 maxillary prominences
4. 2 mandibular prominences
EMBRYOLOGY
EMBRYOLOGY
During the fifth week, two fast growing ridges, the
lateral and medial nasal swellings, surround the nasal
vestige.
The lateral swellings will form the alae of the nose, the
medial swellings will give rise to four areas :
(1) the middle portion of the nose
(2) the middle portion of the upper lip
(3) the middle portion of the maxilla
(4) the entire primary palate
Simultaneously the maxillary swellings will approach the
medial and lateral nasal swellings but remain separated
from them by well marked grooves.
During the next 2 weeks, the appearance of the face
changes considerably.
The maxillary swellings continue to grow in a medial
direction and compress the medial nasal swellings
toward the midline.
Subsequently these swellings simultaneously merge
with each other and with the maxillary swellings
laterally.
Hence the upper lip is formed by the two medial nasal
swellings and the two maxillary swellings.
The two medial swellings merge not only at the
surface but also at the deeper level.
The structures formed by the two merged swellings are
known together as the intermaxillary segament which is
comprised of
:
three components
(1) a labial component, which forms the philtrum of the
upper lip
(2) an upper jaw component, which carries the four incisor
teeth
(3) a palatal component, which forms the triangular primary
palate.
Two shelflike outgrowths from the maxillary swellings
form the secondary palate.
These palatine shelves appear in the sixth week of
development and are directed obliquely downward on
either side of the tongue.
In the seventh week, however, the palatine shelves
ascend to attain a horizontal position above the tongue
and fuse with each other, thereby forming the
secondary palate.
Anteriorly the shelves fuse with the triangular primary
palate, and the incisive foramen is formed at this
junction.
Cleft lip and palate
Cleft lip : is a birth defect that results in a unilateral
or bilateral opening in the upper lip between the
mouth and nose (interruption of development before
7th week lead to lip deformity).
Cleft palate : is a birth defect characterized by
an opening in the roof of the mouth caused by a
lack of tissue development( interruption of
development .
(
before 12th week lead to palate
deformity
.
Development Of cleft :
1.Cleft Lip :
:
Various theories have been given for its development
1.Failure of fusion between median nasal process and
maxillary process
2.Failure of mesodermal migration between the two
layered
epithelial membrane .This leads to breakdown
and cleft formation.
3.Rupture of cyst formed at the site of fusion.
:
2.Cleft palate
:
Various theories have been given
1.Alteration in intrinsic palatal shelf force
2.Failure of tongue to dropdown
3.Non fusion of shelves
4.Failure of mesodermal migration
5.Rupture of cyst formed at the siteof fusion
Etiology
1.GENETIC FACTOR AND ASSOCIATED WITH SOME
SYNDROME LIKE PIERRE ROBIN SYNDROME.
VIT. A,B DEFICIENCY))2.NUTRITIONAL DISTURBANCES
DURING DEVELOPMENT
3.PHYSIOLOGIC ,EMOTIONAL OR TRAUMATIC STRESSES
DURING DEVELOPMENT
4. DEFECTIVE VASCULAR SUPPLY TO AREA INVOLVED
5.MECHANICAL DISTURBANCES WHERE THE SIZE OF THE
TONGUE MAY PREVENT UNION PARTS
6.VARIOUS ENVIRONMENTAL FACTOR LIKE :
INFECTION (E.G. RUBELLA)
EXPOSURE TO RADIATION
DRUGS (E.G. THALIDOMIDE , ANTI
EPILEPTIC DRUGS , HORMONAL PILLS)
6. MATERNAL CONSUMPTION OF ALCOHOL AND SMOKING
General Classification
1- Veau classification
2- Kernahan and Stark classification
3- Kernahan classification
4- Harkins' classification
5- Spina classification
6- Tessier's classification
-Tessier described a classification scheme that is
universally utilised,
in a landmark article of 1976.
Oro-facial clefts can manifest as:
 Unilateral or bilateral
 Complete, incomplete, or microform (e.g., sub-
mucous cleft palate)
 Clefting of the lip with or without the palate, or of the
palate in isolation
 Atypical cranio-facial clefts
Cleft lip and palate
complete : cleft involves the entire primary and secondary palates. It
extends from the uvula all the way into the alveolar ridge. It
involves both the primary palate and secondary palate.
Types
-Unilateral
-Bilateral
incomplete: cleft starts at the back of the palate with the uvula and
extends forward. It may or may not reach the incisive foramen. In
simpler terms, it only involves the secondary palate as it does not
extend all the way forward to include the alveolar ridge.
Bifid Uvula: The least severe of the
incomplete clefts in appearance, a bifid
uvula is the most common palatal cleft. It is
also referred to as a “cleft uvula.” A bifid
uvula appears as a splitting or forking of
the uvula. It may be very subtle, evidenced
only by a small notch, or the uvula may
appear as two distinct entities. A bifid uvula
in and of itself is not problematic. This
occurs in about 2 percent of the population.
However, usually a bifid uvula is indicative
of a submucosal cleft.
Submucosal Cleft: A submucosal cleft is a cleft that is
under the mucosa that lines the roof of the mouth --
hence the term “sub.” Because a submucosal cleft is
under the mucosa, the only physical indicator of its
presence may be a bifid uvula. Even though not seen
from the surface, the muscles of the palate are not
joined at the midline in a submucosal cleft. This creates
an inability to move the palate for some speech sounds.
Hence, a submucosal cleft is usually diagnosed when a
child has abnormal speech development and a bifid
uvula is present.
Soft Palate Cleft: A cleft of the soft palate runs from
the tip of the uvula and stops before or at the junction
of the soft and hard palate. Not only is it more obvious
in its appearance than a submucosal cleft, it creates
the same speech problems as a submucosal cleft. The
more severe (longer) soft palate clefts are detected at
birth due to feeding difficulties. The cleft of the palate
makes it difficult for the infant to create a tight oral seal
around the nipple. As a result, the infant may not be
able to suckle. A partial or shorter soft palate cleft may
not show symptoms at birth or may reveal itself as
nasal reflux of liquids or foods.
Soft and Hard Palate Cleft: A cleft that
involves both the hard and soft palate will
include the entire soft palate and any part of
the hard palate up to the incisive foramen.
The most severe form involves the entire
secondary palate, seen as a gap in the palate
from the tip of the uvula to the incisive
foramen. This is the most overt of the
incomplete palate clefts. Similar to the
isolated soft palate clefts, the combined soft
and hard palate cleft is usually detected at
birth because of feeding problems. Speech
development will be impaired.
Cleft lip and palate
complete: cleft extends all the way from the lip to the nose, The orbicularis oris
muscle is not in continuity, Instead of encircling the mouth, the muscle inserts into
the base of the nose on both sides of the cleft. This disruption creates difficulty
speaking, eating and drinking. The nose is distorted with a cleft lip deformity. The
nostril is widened and the floor of the nostril is missing
Unilateral: only affects one side of the
upper lip, Two thirds of the Cupid’s bow,
one philtral column and the philtral dimple
are preserved on the noncleft/normal sid
Bilateral: A bilateral complete cleft lip affects both the right and
left sides of the lip. There are no philtral columns, no philtral
dimple, and there is no orbicularis muscle in the central
segment. On both sides, the cleft extends from the vermillion to
the nostril. The lack of continuity in the muscle makes clear
speech difficult for these individuals. Feeding can be more
difficult.
There is nasal distortion with a bilateral complete cleft lip. Both
alar rims are widened, the nasal sills are missing and the nose
takes on a flattened appearance.
Incomplete: can take on a variety of appearances. There may be just a small
gap or cleft in the vermillion or it may slightly extend into the skin above the lip
or extend almost to the nostril. As with a complete cleft lip deformity, the nose
has some distortion. The distortion is usually to a lesser degree. The nostril
may be widened, but the floor of the nostril is intact. Additionally, there is a
bridge of tissue at the base of the nostril on the cleft side. This is known as a
Simonart’s band
Unilateral: has clefting of the lip on one side
only. There is a normal philtral column,
Cupid's bow and philtral dimple on the side
without a cleft. What makes it different from
a complete cleft lip is that some orbicularis
muscle fibers may cross the cleft
Bilateral: A bilateral cleft lip has a gap on both sides of the upper
lip. Just like with a bilateral complete cleft lip, the philtral columns
are affected. To what degree depends on how far up the cleft
extends from the vermillion. There may be some orbicularis muscle
intact. The nostril sills are intact. The philtral dimple is intact.
In a bilateral incomplete cleft lip deformity, the nose is affected,
although not to the same degree as with a bilateral complete cleft
lip deformity. In those individuals with a bilateral cleft lip deformity,
one side may be an incomplete deformity and the other side a
complete deformity.
Mixed Bilateral Incomplete and Complete
Cleft Lip
In those who have a bilateral cleft lip, one side
may be an incomplete cleft lip and the other
side a complete cleft lip deformity. An
incomplete cleft lip may be barely imperceptible.
A microform cleft lip
(also known as a "forme fruste") is the mildest version
of a cleft lip, and is categorized as an incomplete cleft.
A microform cleft lip does not have the obvious cleft
appearance of the other clefts. It may simply appear
as a vertical scar from the lip to the nose. There may
be a notch in the vermillion border and the nose may
be affected. While a microform cleft may not be
obvious, there may still be a problem with functionality.
There is some disruption of the continuity of the
orbicularis oris muscle. This may cause eating and
drinking issues as well as speech issues.
The nose is usually normal with a microform cleft
deformity
Cleft lip and palate
Diagnosis of cleft lip and palate during pregnancy (antenatal
diagnosis)
•cleft lip and cleft palate are being diagnosed by ultrasound before the baby is
born. An ultrasound is a test that uses sound waves to create pictures of the
developing fetus. When analyzing the pictures, a doctor may detect an
abnormality in the facial structures.
A vertical hypo-echoic region through the fetal upper lip usually represents the
defect in cleft lip
Cleft lip may be detected with ultrasound beginning around the 18th-20 week of
pregnancy. As the fetus continues developing, it may be easier to accurately
diagnose a cleft lip. Cleft palate that occurs on its own is more difficult to
diagnose using ultrasound, since it can be difficult to see inside the fetus' mouth.
Occasionally a cleft is not picked up on the scan because the face is not visible
on the scan. Cleft palate without cleft lip is difficult to detect by antenatal scans
Cleft lip and palate
Advantages of Prenatal
Diagnosis
Time for parental education
Time for parental psychological preparation
Opportunity to investigate other associated
anomalies
Gives parents the choice of continuing the
pregnancy
Opportunity for fetal
Diagnosis of cleft lip and palate after birth
Most cases of cleft lip and cleft palate are immediately apparent at birth
and don't require special tests for diagnosis.
Diagnosis may be made at birth using complete physical examination by
the physician. Since many of the associated syndromes show defects in
the genes and chromosomes, a chromosomal analysis is suggested for
the baby.
Diagnosis of associated problems like feeding problems, hearing loss,
ear infections, speech defects and teething problems is also important in
treatment of cleft lip and/or palate
Cleft lip and palate team
Pediatrician :provide medical care and refer to plastic
surgeon
plastic surgeon : initial lip repair and palatal surgery ,
pharyngoplasty and nose surgery
Maxillofacial surgery :bone grafting and orthopedic
surgery in later stage.
Neurosurgery :for any craniofacial syndrome
Pedodontic: the key member to asses patient and
his parents , monitor growth ,guide occlusion and
facial growth
Orthodontic: definitive orthodontic treatment once full
permanent arch erupt
Speech pathologist: monitor speech development to
normal ,test for adequate palate and pharyngeal
closure
Audiologist :test hearing in infant and
childhood
Psychologist: play important role when child
and family under stress
Problems Associated With Cleft Lip
and Palate
Feeding
Dental problems
Nasal Deformity and Esthetic Problems
Ear Problems
Speech Difficulties
Feeding Difficulties
 Cleft lip= makes it more difficult for an infant to suck
on a nipple
 Cleft Palate= may cause formula or breast milk to be
accidently taken up into the nasal cavity
 Inability to create negative pressure inside oral cavity
 Frequent regurgitations
 Upper respiratory tract infections
 Management of feeding problems :
i) For cleft lip patient
1- Breast feeding: mother can close cleft by the areola or
her hand to provide a seal.
2- Bottle feeding : a broad based nipple on a regular bottle
to provide the seal.
ii) For cleft palate :
Depending on severity of the cleft a variety of feeding
devices are available :
a) Soft premature nipples: conforms better to the palatal
defect and thus improves sucking.
b) Cross cut nipples: allow for easier flow of formula, and
thus decreasing strain on the child.
c) Long nipples: can be positioned posterior to the defect.
Dental Problems
 Local Dental Problems:
 Congenitally Missing teeth, Hypodontia, Hyperdontia,
Oligodontia
 Presence of natal and neonatal teeth
 Anamalies of tooth morphology like microdontia, macrodontia
etc
 Fused teeth
 Enamel Hypoplasia
 Poor periodontal support, early loss of teeth
 Gemination, Dilacerations
 Orthodontics Problems:
 Class III tendency
 Anterior and Posterior Cross bite
 Spacing and crowding
Nasal Deformity and Esthetic
Problems
Facial Disfigurements
Poor nasal shape
Scar marks of surgeries
Poor lip function during
speech
Poor dental alignment and
smile
Ear Problems
 Middle ear disease - 22% to 88%
 Conductive hearing loss and chronic suppurative otitis media
may result
 Repeated tympanostomy tube placement
Cause's of ear problem
 Mechanical
 Infection
 Dynamic
Speech Problems:
 Hearing loss hampers proper development of speech
 Velopharyngeal Insufficiency (VPI)
 Abnormal air
 Poor pronunciation of Bilabial, Labiodental,
Linguoalveolar sounds
General Management Protocol for the
Cleft Patient
Immediately after the birth –
pediatric consultation,
feeding instructions,
evaluation by geneticist
diagnosis of life expectancy of a child
At 10 to 12 weeks - surgical repair of the lip
Cleft Lip Repair Goals
 Approximate cleft edges
 Maintain Cupid's bow and philtrum
 Align vermillion border
 Create an intact nasal floor
 Reconstituting the circumferential
integrity of the orbicularis oris muscle
From age 1 year to 18 months –
team evaluation and surgical repair of cleft palate
advantages for early closure of palatal defects:-
(1) better palatal and pharyngeal muscle development
(2) ease of feeding
(3) better development of phonation skills
(4) better auditory tube function
(6) improved psychologic state for parents and baby.
If the cleft is very wide, it is better to delay closure.
- Delayed palatal surgery will limit the inhibition of the
maxillary growth and minimizing the need for surgery to
widen the maxilla.
But, will lead to development of compensatory speech
and swallowing pattern, which are not easily corrected.
During this period we use
Non-Surgical methods
Dental Obturator. a plastic/acrylic, removable roof of the
mouth, which aids in speech, eating, and proper air flow.
For high-risk patients or those that refuse surgery.
Advantage- High rate of closure
Disadvantage- Need to wear a prosthesis, and need to
modify prosthesis as child grows.
Three months after palate repair- team
evaluation for speech and language assessment.
Three to six years –
 team evaluation
 behavioral intervention as
needed.
 Speech therapy
 treatment for middle year
infection,
 fistula repair,
 psychological evaluation.
At seven years - Orthodontic treatment phase I.
Nine to eleven years - alveolar bone grafting to
 Provide bone for the eruption and/or orthodontic
repositioning of teeth
 Closure of oro-nasal fistulas
 Stabilization of the pre-maxilla in bilateral cases
Twelve years or later - Full orthodontic treatment phase II.
Fifteen to eighteen years - at the end of orthodontic
treatment, placement of implants, fixed bridge, etc. for
missing teeth.
Cleft lip and palate
Eighteen to twenty-one years –
 when most of growth is completed,
Surgical advancement of maxilla, if
required.
 Final nose and lip revision -
rhinoplasty, 16-18 years.
In conclusion:
 Family troppus
lacitirc si
ruoy rof
.dlihc
evoL
dna
gnidnatsrednu
lliw
pleh
mih
ro
reh
worg
pu
htiw
a
esnes
fo
fles
-
meetse
taht
sdnetxe
dnoyeb
eht
lacisyhp
tcefed
.
Cleft lip and palate
 Langman Essential medical embryology for
T.W.salder
Conlemporary oral and maxillofacial
surgery
Hand book of Pediatric Dentistry By
Richard P widmer
Cleft lip and palate

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Cleft lip and palate

  • 2. Head and Neck of 4-Week Old Embryo EMBRYOLOGY
  • 3. In 4-week old 5 mesenchymal prominence can be recognized : 1. Unpaired Frontonasal Prominence 2. Medial and Lateral Nasal prominences 3. 2 maxillary prominences 4. 2 mandibular prominences EMBRYOLOGY
  • 4. EMBRYOLOGY During the fifth week, two fast growing ridges, the lateral and medial nasal swellings, surround the nasal vestige. The lateral swellings will form the alae of the nose, the medial swellings will give rise to four areas : (1) the middle portion of the nose (2) the middle portion of the upper lip (3) the middle portion of the maxilla (4) the entire primary palate Simultaneously the maxillary swellings will approach the medial and lateral nasal swellings but remain separated from them by well marked grooves.
  • 5. During the next 2 weeks, the appearance of the face changes considerably. The maxillary swellings continue to grow in a medial direction and compress the medial nasal swellings toward the midline. Subsequently these swellings simultaneously merge with each other and with the maxillary swellings laterally. Hence the upper lip is formed by the two medial nasal swellings and the two maxillary swellings. The two medial swellings merge not only at the surface but also at the deeper level.
  • 6. The structures formed by the two merged swellings are known together as the intermaxillary segament which is comprised of : three components (1) a labial component, which forms the philtrum of the upper lip (2) an upper jaw component, which carries the four incisor teeth (3) a palatal component, which forms the triangular primary palate.
  • 7. Two shelflike outgrowths from the maxillary swellings form the secondary palate. These palatine shelves appear in the sixth week of development and are directed obliquely downward on either side of the tongue. In the seventh week, however, the palatine shelves ascend to attain a horizontal position above the tongue and fuse with each other, thereby forming the secondary palate. Anteriorly the shelves fuse with the triangular primary palate, and the incisive foramen is formed at this junction.
  • 9. Cleft lip : is a birth defect that results in a unilateral or bilateral opening in the upper lip between the mouth and nose (interruption of development before 7th week lead to lip deformity). Cleft palate : is a birth defect characterized by an opening in the roof of the mouth caused by a lack of tissue development( interruption of development . ( before 12th week lead to palate deformity
  • 10. . Development Of cleft : 1.Cleft Lip : : Various theories have been given for its development 1.Failure of fusion between median nasal process and maxillary process 2.Failure of mesodermal migration between the two layered epithelial membrane .This leads to breakdown and cleft formation. 3.Rupture of cyst formed at the site of fusion.
  • 11. : 2.Cleft palate : Various theories have been given 1.Alteration in intrinsic palatal shelf force 2.Failure of tongue to dropdown 3.Non fusion of shelves 4.Failure of mesodermal migration 5.Rupture of cyst formed at the siteof fusion
  • 12. Etiology 1.GENETIC FACTOR AND ASSOCIATED WITH SOME SYNDROME LIKE PIERRE ROBIN SYNDROME. VIT. A,B DEFICIENCY))2.NUTRITIONAL DISTURBANCES DURING DEVELOPMENT 3.PHYSIOLOGIC ,EMOTIONAL OR TRAUMATIC STRESSES DURING DEVELOPMENT 4. DEFECTIVE VASCULAR SUPPLY TO AREA INVOLVED 5.MECHANICAL DISTURBANCES WHERE THE SIZE OF THE TONGUE MAY PREVENT UNION PARTS 6.VARIOUS ENVIRONMENTAL FACTOR LIKE : INFECTION (E.G. RUBELLA) EXPOSURE TO RADIATION DRUGS (E.G. THALIDOMIDE , ANTI EPILEPTIC DRUGS , HORMONAL PILLS) 6. MATERNAL CONSUMPTION OF ALCOHOL AND SMOKING
  • 13. General Classification 1- Veau classification 2- Kernahan and Stark classification 3- Kernahan classification 4- Harkins' classification 5- Spina classification 6- Tessier's classification
  • 14. -Tessier described a classification scheme that is universally utilised, in a landmark article of 1976. Oro-facial clefts can manifest as:  Unilateral or bilateral  Complete, incomplete, or microform (e.g., sub- mucous cleft palate)  Clefting of the lip with or without the palate, or of the palate in isolation  Atypical cranio-facial clefts
  • 16. complete : cleft involves the entire primary and secondary palates. It extends from the uvula all the way into the alveolar ridge. It involves both the primary palate and secondary palate. Types -Unilateral -Bilateral
  • 17. incomplete: cleft starts at the back of the palate with the uvula and extends forward. It may or may not reach the incisive foramen. In simpler terms, it only involves the secondary palate as it does not extend all the way forward to include the alveolar ridge. Bifid Uvula: The least severe of the incomplete clefts in appearance, a bifid uvula is the most common palatal cleft. It is also referred to as a “cleft uvula.” A bifid uvula appears as a splitting or forking of the uvula. It may be very subtle, evidenced only by a small notch, or the uvula may appear as two distinct entities. A bifid uvula in and of itself is not problematic. This occurs in about 2 percent of the population. However, usually a bifid uvula is indicative of a submucosal cleft.
  • 18. Submucosal Cleft: A submucosal cleft is a cleft that is under the mucosa that lines the roof of the mouth -- hence the term “sub.” Because a submucosal cleft is under the mucosa, the only physical indicator of its presence may be a bifid uvula. Even though not seen from the surface, the muscles of the palate are not joined at the midline in a submucosal cleft. This creates an inability to move the palate for some speech sounds. Hence, a submucosal cleft is usually diagnosed when a child has abnormal speech development and a bifid uvula is present. Soft Palate Cleft: A cleft of the soft palate runs from the tip of the uvula and stops before or at the junction of the soft and hard palate. Not only is it more obvious in its appearance than a submucosal cleft, it creates the same speech problems as a submucosal cleft. The more severe (longer) soft palate clefts are detected at birth due to feeding difficulties. The cleft of the palate makes it difficult for the infant to create a tight oral seal around the nipple. As a result, the infant may not be able to suckle. A partial or shorter soft palate cleft may not show symptoms at birth or may reveal itself as nasal reflux of liquids or foods.
  • 19. Soft and Hard Palate Cleft: A cleft that involves both the hard and soft palate will include the entire soft palate and any part of the hard palate up to the incisive foramen. The most severe form involves the entire secondary palate, seen as a gap in the palate from the tip of the uvula to the incisive foramen. This is the most overt of the incomplete palate clefts. Similar to the isolated soft palate clefts, the combined soft and hard palate cleft is usually detected at birth because of feeding problems. Speech development will be impaired.
  • 21. complete: cleft extends all the way from the lip to the nose, The orbicularis oris muscle is not in continuity, Instead of encircling the mouth, the muscle inserts into the base of the nose on both sides of the cleft. This disruption creates difficulty speaking, eating and drinking. The nose is distorted with a cleft lip deformity. The nostril is widened and the floor of the nostril is missing Unilateral: only affects one side of the upper lip, Two thirds of the Cupid’s bow, one philtral column and the philtral dimple are preserved on the noncleft/normal sid Bilateral: A bilateral complete cleft lip affects both the right and left sides of the lip. There are no philtral columns, no philtral dimple, and there is no orbicularis muscle in the central segment. On both sides, the cleft extends from the vermillion to the nostril. The lack of continuity in the muscle makes clear speech difficult for these individuals. Feeding can be more difficult. There is nasal distortion with a bilateral complete cleft lip. Both alar rims are widened, the nasal sills are missing and the nose takes on a flattened appearance.
  • 22. Incomplete: can take on a variety of appearances. There may be just a small gap or cleft in the vermillion or it may slightly extend into the skin above the lip or extend almost to the nostril. As with a complete cleft lip deformity, the nose has some distortion. The distortion is usually to a lesser degree. The nostril may be widened, but the floor of the nostril is intact. Additionally, there is a bridge of tissue at the base of the nostril on the cleft side. This is known as a Simonart’s band Unilateral: has clefting of the lip on one side only. There is a normal philtral column, Cupid's bow and philtral dimple on the side without a cleft. What makes it different from a complete cleft lip is that some orbicularis muscle fibers may cross the cleft Bilateral: A bilateral cleft lip has a gap on both sides of the upper lip. Just like with a bilateral complete cleft lip, the philtral columns are affected. To what degree depends on how far up the cleft extends from the vermillion. There may be some orbicularis muscle intact. The nostril sills are intact. The philtral dimple is intact. In a bilateral incomplete cleft lip deformity, the nose is affected, although not to the same degree as with a bilateral complete cleft lip deformity. In those individuals with a bilateral cleft lip deformity, one side may be an incomplete deformity and the other side a complete deformity.
  • 23. Mixed Bilateral Incomplete and Complete Cleft Lip In those who have a bilateral cleft lip, one side may be an incomplete cleft lip and the other side a complete cleft lip deformity. An incomplete cleft lip may be barely imperceptible. A microform cleft lip (also known as a "forme fruste") is the mildest version of a cleft lip, and is categorized as an incomplete cleft. A microform cleft lip does not have the obvious cleft appearance of the other clefts. It may simply appear as a vertical scar from the lip to the nose. There may be a notch in the vermillion border and the nose may be affected. While a microform cleft may not be obvious, there may still be a problem with functionality. There is some disruption of the continuity of the orbicularis oris muscle. This may cause eating and drinking issues as well as speech issues. The nose is usually normal with a microform cleft deformity
  • 25. Diagnosis of cleft lip and palate during pregnancy (antenatal diagnosis) •cleft lip and cleft palate are being diagnosed by ultrasound before the baby is born. An ultrasound is a test that uses sound waves to create pictures of the developing fetus. When analyzing the pictures, a doctor may detect an abnormality in the facial structures. A vertical hypo-echoic region through the fetal upper lip usually represents the defect in cleft lip Cleft lip may be detected with ultrasound beginning around the 18th-20 week of pregnancy. As the fetus continues developing, it may be easier to accurately diagnose a cleft lip. Cleft palate that occurs on its own is more difficult to diagnose using ultrasound, since it can be difficult to see inside the fetus' mouth. Occasionally a cleft is not picked up on the scan because the face is not visible on the scan. Cleft palate without cleft lip is difficult to detect by antenatal scans
  • 27. Advantages of Prenatal Diagnosis Time for parental education Time for parental psychological preparation Opportunity to investigate other associated anomalies Gives parents the choice of continuing the pregnancy Opportunity for fetal
  • 28. Diagnosis of cleft lip and palate after birth Most cases of cleft lip and cleft palate are immediately apparent at birth and don't require special tests for diagnosis. Diagnosis may be made at birth using complete physical examination by the physician. Since many of the associated syndromes show defects in the genes and chromosomes, a chromosomal analysis is suggested for the baby. Diagnosis of associated problems like feeding problems, hearing loss, ear infections, speech defects and teething problems is also important in treatment of cleft lip and/or palate
  • 29. Cleft lip and palate team Pediatrician :provide medical care and refer to plastic surgeon plastic surgeon : initial lip repair and palatal surgery , pharyngoplasty and nose surgery Maxillofacial surgery :bone grafting and orthopedic surgery in later stage.
  • 30. Neurosurgery :for any craniofacial syndrome Pedodontic: the key member to asses patient and his parents , monitor growth ,guide occlusion and facial growth Orthodontic: definitive orthodontic treatment once full permanent arch erupt Speech pathologist: monitor speech development to normal ,test for adequate palate and pharyngeal closure
  • 31. Audiologist :test hearing in infant and childhood Psychologist: play important role when child and family under stress
  • 32. Problems Associated With Cleft Lip and Palate Feeding Dental problems Nasal Deformity and Esthetic Problems Ear Problems Speech Difficulties
  • 33. Feeding Difficulties  Cleft lip= makes it more difficult for an infant to suck on a nipple  Cleft Palate= may cause formula or breast milk to be accidently taken up into the nasal cavity  Inability to create negative pressure inside oral cavity  Frequent regurgitations  Upper respiratory tract infections
  • 34.  Management of feeding problems : i) For cleft lip patient 1- Breast feeding: mother can close cleft by the areola or her hand to provide a seal. 2- Bottle feeding : a broad based nipple on a regular bottle to provide the seal. ii) For cleft palate : Depending on severity of the cleft a variety of feeding devices are available : a) Soft premature nipples: conforms better to the palatal defect and thus improves sucking. b) Cross cut nipples: allow for easier flow of formula, and thus decreasing strain on the child. c) Long nipples: can be positioned posterior to the defect.
  • 35. Dental Problems  Local Dental Problems:  Congenitally Missing teeth, Hypodontia, Hyperdontia, Oligodontia  Presence of natal and neonatal teeth  Anamalies of tooth morphology like microdontia, macrodontia etc  Fused teeth  Enamel Hypoplasia  Poor periodontal support, early loss of teeth  Gemination, Dilacerations  Orthodontics Problems:  Class III tendency  Anterior and Posterior Cross bite  Spacing and crowding
  • 36. Nasal Deformity and Esthetic Problems Facial Disfigurements Poor nasal shape Scar marks of surgeries Poor lip function during speech Poor dental alignment and smile
  • 37. Ear Problems  Middle ear disease - 22% to 88%  Conductive hearing loss and chronic suppurative otitis media may result  Repeated tympanostomy tube placement
  • 38. Cause's of ear problem  Mechanical  Infection  Dynamic
  • 39. Speech Problems:  Hearing loss hampers proper development of speech  Velopharyngeal Insufficiency (VPI)  Abnormal air  Poor pronunciation of Bilabial, Labiodental, Linguoalveolar sounds
  • 40. General Management Protocol for the Cleft Patient Immediately after the birth – pediatric consultation, feeding instructions, evaluation by geneticist diagnosis of life expectancy of a child
  • 41. At 10 to 12 weeks - surgical repair of the lip Cleft Lip Repair Goals  Approximate cleft edges  Maintain Cupid's bow and philtrum  Align vermillion border  Create an intact nasal floor  Reconstituting the circumferential integrity of the orbicularis oris muscle
  • 42. From age 1 year to 18 months – team evaluation and surgical repair of cleft palate advantages for early closure of palatal defects:- (1) better palatal and pharyngeal muscle development (2) ease of feeding (3) better development of phonation skills (4) better auditory tube function (6) improved psychologic state for parents and baby.
  • 43. If the cleft is very wide, it is better to delay closure. - Delayed palatal surgery will limit the inhibition of the maxillary growth and minimizing the need for surgery to widen the maxilla. But, will lead to development of compensatory speech and swallowing pattern, which are not easily corrected. During this period we use Non-Surgical methods Dental Obturator. a plastic/acrylic, removable roof of the mouth, which aids in speech, eating, and proper air flow. For high-risk patients or those that refuse surgery. Advantage- High rate of closure Disadvantage- Need to wear a prosthesis, and need to modify prosthesis as child grows. Three months after palate repair- team evaluation for speech and language assessment.
  • 44. Three to six years –  team evaluation  behavioral intervention as needed.  Speech therapy  treatment for middle year infection,  fistula repair,  psychological evaluation.
  • 45. At seven years - Orthodontic treatment phase I. Nine to eleven years - alveolar bone grafting to  Provide bone for the eruption and/or orthodontic repositioning of teeth  Closure of oro-nasal fistulas  Stabilization of the pre-maxilla in bilateral cases Twelve years or later - Full orthodontic treatment phase II. Fifteen to eighteen years - at the end of orthodontic treatment, placement of implants, fixed bridge, etc. for missing teeth.
  • 47. Eighteen to twenty-one years –  when most of growth is completed, Surgical advancement of maxilla, if required.  Final nose and lip revision - rhinoplasty, 16-18 years.
  • 48. In conclusion:  Family troppus lacitirc si ruoy rof .dlihc evoL dna gnidnatsrednu lliw pleh mih ro reh worg pu htiw a esnes fo fles - meetse taht sdnetxe dnoyeb eht lacisyhp tcefed .
  • 50.  Langman Essential medical embryology for T.W.salder Conlemporary oral and maxillofacial surgery Hand book of Pediatric Dentistry By Richard P widmer