1. Global Markets for Treatments for Syndromes of Progressive
Ataxia and Weakness Disorders
Report Details:
Published:October 2012
No. of Pages: 170
Price: Single User License – US$4850
•The global market for treatments for syndromes of progressive ataxia and weakness disorders
was valued at nearly $14 billion in 2011 and should reach nearly $15 billion in 2012. Total market
value is expected to reach nearly $23.5 billion in 2017 after increasing at a five-year compound
annual growth rate (CAGR) of 9.4%.
•Treatments for progressive weakness syndromes should total nearly $14.6 billion in 2012 and
$22.8 billion in 2017, a CAGR of 9.4%.
•Progressive ataxia treatments are expected to have a value of $356.4 million in 2012 and $620.7
million in 2017, a CAGR of 11.7%.
STUDY OBJECTIVES
BCC’s goal in conducting this study is to provide an overview of the current and future
characteristics of the global market for treatments of neurodegenerative (i.e., progressive ataxia
and weakness) disorders. The key objective is to present a comprehensive analysis and the
future direction of treatments for these disorders as the market efforts toward drug and therapy
development evolve.
This report explores present and future strategies within the progressive ataxia and weakness
disorders market, which includes treatments and therapies for dysfunctions, including progressive
ataxia and progressive weakness disorder syndromes. The market’s improvisation, setbacks and
needs are also discussed. The comparisons, usage, advantages and disadvantages of different
types of technologies, including small-molecule and monoclonal antibodies, are also presented.
A detailed analysis of the industry structure has been conducted. Revenues are broken down by
the neurodegenerative dysfunction. Sales figures are estimated for the five-year period from 2012
through 2017.
The report discusses applications for neurodegenerative disorder treatment and therapy
technologies, with emphasis on small-molecule and monoclonal antibodies technology. The report
also covers significant patents and their allotments in each category.
REASONS FOR DOING THIS STUDY
Extensive research in the field of progressive ataxia and weakness disorders as well as
collaborations with research institutes have highlighted the importance of understanding the nature
of these disorders. New technology development is providing modifying therapies for the late

2. stages of these disorders. Collaborations among research institutes and pharmaceutical
companies are becoming more common, as state-of-the-art technology is being explored to
develop more-efficient products and therapies.
R&D spending, increasing competition, patent expiries and new technologies are shifting the
market in a new direction. The market’s overall revenue has increased from 2009 to 2011, and it
continues to show growth, as new advancements, product launches and collaborations will have
positive influences for the foreseeable future. This study looks at most of the systems affected by
these factors.
Acquisition strategies and company collaborations are also covered in this report. This study
discusses the strength and weaknesses of each technology in light of the new developments,
growing competition and changing customer needs.
CONTRIBUTIONS OF THE STUDY AND FOR WHOM
This study contributes to the areas of market growth in Friedreich’s ataxia, Gerstmann-Straussler-
Scheinker disease, Machado-Joseph disease, amyotrophic lateral sclerosis, progressive bulbar
palsy, hereditary spastic paraplegia, hereditary neuropathies and multiple sclerosis.
Pharmaceutical biotechnical companies, research institutes and physicians will find this study of
interest.
SCOPE OF THE STUDY
The scope of this study encompasses the neurodegenerative (i.e., progressive ataxia and
weakness) disorders in the pharmaceutical and biotechnology markets. BCC analyzes each
market and its applications, the regulatory environments, and the technologies involved, as well as
market projections and market shares. Technological issues include the latest trends and
developments. The emerging market for enzyme inhibitors includes such countries as India,
China, Japan, South Korea, Taiwan, Canada, Africa, Australia and New Zealand.
METHODOLOGY
Both primary and secondary research methodologies were used in preparing this study. BCC
conducted a comprehensive literature search, which included technical newsletters and journals,
among other sources. Data were collected through interviews and correspondence with technical
experts at companies that manufacture enzyme inhibitors. Projections were based on estimates
that were calculated such using information as the current number of end users, potential end
users, mergers and acquisitions, and market trends.
INFORMATION SOURCES
Many companies within the industry were surveyed to obtain data for this study. These included
manufacturers and end users of enzyme inhibitors in therapeutic categories and various disease-
sector industries. Data were gathered from various industry sources. BCC spoke with officials
within the industry and also reviewed newsletters, company literature and product literature, as
well as a host of technical articles, journals, indices and abstracts. Exhaustive investigations of
databases by key terminology were completed. In addition, data were compiled from current
financial, trade and government sources.
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3. Major points covered in Table of Contents of this report include
Table Of Contents
Chapter- 1: Introduction - Complimentary 3
Study Objectives
Reasons For Doing This Study
Contributions Of The Study And For Whom
Scope Of The Study
Methodology
Information Sources
About The Author
Related Bcc Research Reports
Bcc On-Line Services
Disclaimer
Chapter- 2: Executive Summary 2
Table Summary : Global Market For Progressive Ataxia And Weakness Disorders, Through 2017
Figure Summary : Global Market For Progressive Ataxia And Weakness Disorders, 2010-2017
Chapter- 3: Overview 6
Definitions
Classification
Progressive Ataxia And Weakness Disorders
Diagnostic Tests For Progressive Ataxia And Weakness Disorders
Chapter- 4: Regulatory Aspects 4
Drug Approvals For Progressive Ataxia And Weakness Disorders
Regulatory Developments Of Products Used To Treat Progressive Ataxia And Weakness
Disorders
Chapter- 5: New Developments 8
Table 6 : New Developments For The Treatment Of Progressive Ataxia And Weakness Disorders,
2012
Table 7 : New Developments For The Treatment Of Progressive Ataxia And Weakness Disorders,
2011
Table 8 : New Developments In The Treatment Of Progressive Ataxia And Weakness Disorders,
2010
Chapter- 6: Global Markets 13
Markets By Dysfunction
Markets By Disorders
Market By Regions
Markets By Technology
Chapter- 7: Progressive Ataxia Syndrome Market 27
Market By Disease Type
Market By Region
Market By Technology
Industry Structure

4. Chapter- 8: Progressive Weakness Syndrome Markets 48
Market By Disease Type
Markets By Region
Market By Technology
Industry Structure
Chapter- 9: Patent Analysis 13
Patents By Year
Patents By Disease Category
Patents By Disease Type
Patents By Country
Patents By Company
Patents By Assignee
Chapter- 10: Current Situation 6
Market Trends
Additional Drivers For Progressive Ataxia And Weakness Disorders Drug Market
Factors Governing The Market
Collaborations, Mergers And Acquisitions
Chapter- 11: Company Profiles 37
Abbott Laboratories
Acorda Therapeutics Inc.
Actavis Elizabeth
Allon Therapeutics Inc
American Regent Inc.
Apotex Inc.
Apotheca, Inc.
App Pharmaceuticals
Astellas Pharma Inc.
Astrazeneca Gmbh
Aurobindo Pharma Ltd
Baxter International Inc.
Biogen Idec
Boehringer Ingelheim Ltd.
Bristol-Myers Squibb
Bryant Ranch Prepack
Cadila Healthcare Ltd.
Caraco Pharmaceutical Laboratories
Cardinal Health
Cognition Pharmaceuticals Llc
Csl Behring
Dr. Reddy's Laboratories Limited
Eisai Co. Ltd
Elan Pharma International Limited

5. Eli Lilly And Company
Emd Millipore Headquarters
Endo Pharmaceuticals Inc
Glaxosmithkline Plc.
Glenmark Generics Limited
H. Lundbeck A/S
Hameln Pharmaceuticals Ltd
Hospira Inc.
Intellect Neurosciences Inc.
Jazz Pharmaceuticals Plc.
Lexicon Pharmaceuticals Inc.
Major Pharmaceuticals
Merck Serono
Merck Sharp & Dohme Limited
Merz Pharma Gmbh & Co Kgaa
Momenta Pharmaceuticals
Mylan Pharmaceuticals
Neuren Pharmaceuticals Ltd.
Neurosearch A/S
Noscira, S.A.
Novartis Ag
Orchid Chemicals & Pharmaceuticals Ltd.
Ortho-Mcneil Janssen Pharmaceuticals Inc.
Par Pharmaceuticals
Perrigo Company
Pfizer Inc.
Pharnext
Physicians Total Care, Inc.
Pliva Hrvatska D.O.O.
Prometheus
Ranbaxy Laboratories Limited
Roche Holding Ltd
Roxane Laboratories Inc.
Sandoz International Gmbh
Sanofi
Santhera Pharmaceuticals
Shionogi & Co.
Sun Pharma
Taj Pharmaceuticals Limited
Takeda Pharmaceutical Company Limited
Tercica, Inc
Teva Pharmaceutical Industries Ltd

6. Torrent Pharma
Ucb S.A.
Udl Laboratories
Upsher-Smith Laboratories
Watson Pharmaceuticals Inc.
West-Ward Pharmaceutical
Chapter- 12: Appendix I: Abbreviations 3
List Of Tables
Summary Table : Global Market For Progressive Ataxia And Weakness Disorders, Through 2017
Table 1 : Classification By Primary Dysfunction
Table 2 : Abbreviated Approvals And New Drug Approvals For Progressive Ataxia And Weakness
Disorders, 2012
Table 3 : New Drug Applications For The Progressive Ataxia And Weakness Disorders
Table 4 : Safety Alerts, 2010-March 2012
Table 5 : Recalls For Drugs Used To Treat Progressive Ataxia And Weakness Disorders,
2010–March 2012
Table 6 : New Developments For The Treatment Of Progressive Ataxia And Weakness Disorders,
2012
Table 7 : New Developments For The Treatment Of Progressive Ataxia And Weakness Disorders,
2011
Table 8 : New Developments In The Treatment Of Progressive Ataxia And Weakness Disorders,
2010
Table 9 : Global Revenues Of Drug Products For The Treatment Of Neurodegenerative
Dysfunctions, Through 2017
Table 10 : Market Share Of Drugs Used For The Treatment Of Neurodegenerative Disorders By
Dysfunctions, 2011
Table 11 : Global Sales Of Drug Products For The Treatment Of Progressive Ataxia And
Weakness Disorders, Through 2017
Table 12 : Market Share Of Drug Products For The Treatment Of Progressive Ataxia And
Weakness Disorders, 2011
Table 13 : Market For Drug Products For The Treatment Of Progressive Ataxia And Weakness
Disorders By Region, Through 2017
Table 14 : Market Share Of Drug Products For The Treatment Of Progressive Ataxia And
Weakness Disorders By Region, 2011
Table 15 : Global Sales Of Drug Products For The Treatment Of Progressive Ataxia And
Weakness Disorders By Technology, Through 2017
Table 16 : Market Share Of Drug Products For The Treatment Of Progressive Ataxia And
Weakness Disorders By Technology, 2011
Table 17 : Sales Of Drug Products For The Treatment Of Progressive Ataxia By Disease Type,
Through 2017
Table 18 : Progressive Ataxia Drug Market By Disease Type, 2011
Table 19 : Progressive Ataxia Drug Market By Region, Through 2017

7. Table 20 : Progressive Ataxia Drug Market By Region, 2011
Table 21 : Friedreich’s Ataxia Drug Market By Region, Through 2017
Table 22 : Gertsmann-Straussler-Scheinker Disease Drug Market By Region, Through 2017
Table 23 : Machado-Joseph Disease Drug Market By Region, Through 2017
Table 24 : Progressive Ataxia Drug Market By Technology, Through 2017
Table 25 : Progressive Ataxia Drugs Share By Technology, 2011
Table 26 : Leading Manufacturers And Suppliers Of Friedreich’s Ataxia Drugs And Therapies
Table 27 : Market Shares For Manufacturers And Distributors Of Friedreich’s Ataxia Drugs, 2011
Table 28 : Leading Manufacturers And Suppliers Of Gerstmann-Straussler-Scheinker Disease
Drugs And Therapies
Table 29 : Market Shares Of Manufacturers And Distributors Of Gertsmann-Straussler-Scheinker
Disease Drugs, 2011
Table 30 : Leading Manufacturers And Suppliers Of Machado-Joseph Disease Drugs And
Therapies
Table 31 : Market Shares Of Manufacturers And Distributors Of Machado-Joseph Disease Drugs,
2011
Table 32 : Progressive Weakness Syndrome Drug Market By Disease Type, Through 2017
Table 33 : Progressive Weakness Drug Market By Disease Type, 2011
Table 34 : Progressive Weakness Syndrome Drug Market By Region, Through 2017
Table 35 : Progressive Weakness Drug Market By Region, 2011
Table 36 : Amyotrophic Lateral Sclerosis Drug Market By Region, Through 2017
Table 37 : Progressive Bulbar Palsy Drug Market By Region, Through 2017
Table 38 : Hereditary Spastic Paraplegia Drug Market By Region, Through 2017
Table 39 : Hereditary Neuropathy Drug Market By Region, Through 2017
Table 40 : Multiple Sclerosis Drug Market By Region, Through 2017
Table 41 : Progressive Weakness Syndrome Drug Market By Technology, Through 2017
Table 42 : Progressive Weakness Market By Technology, 2011
Table 43 : Multiple Sclerosis Drug Market By Technology, Through 2017
Table 44 : Multiple Sclerosis Drug Market Distribution By Technology, 2011
Table 45 : Leading Manufacturers And Suppliers Of Drugs And Therapies For Amyotrophic Lateral
Sclerosis
Table 46 : Market Shares Of Manufacturers And Distributors Amyotrophic Lateral Sclerosis Drugs,
2011
Table 47 : Leading Manufacturers And Suppliers Of Progressive Bulbar Palsy Drugs And
Therapies
Table 48 : Market Shares Of Manufacturers And Distributors Of Progressive Bulbar Palsy Drugs,
2011
Table 49 : Leading Manufacturers And Suppliers Of Hereditary Spastic Paraplegia Drugs And
Therapies
Table 50 : Market Shares Of Manufacturers And Distributors Of Hereditary Spastic Paraplegia
Drugs, 2011
Table 51 : Leading Manufacturers And Suppliers Of Hereditary Neuropathy Drugs And Therapies

8. Table 52 : Market Shares Of Manufacturers And Distributors Of Hereditary Neuropathies Drugs,
2011
Table 53 : Leading Manufacturers And Suppliers Multiple Sclerosis Drugs And Therapies
Table 54 : Market Shares Of Manufacturers And Distributors Of Multiple Sclerosis Drugs, 2011
Table 55 : Total Number Of Patents By Year, 2010-March 2012
Table 56 : Patents By Disease Category, 2010-March 2012
Table 57 : Patents For Progressive Ataxia Syndromes By Disease Type, 2010-2012
Table 58 : Patents For Progressive Weakness And Effect The On Brain And Spinal Cord
Syndromes By Disease Type, 2010-2012
Table 59 : U.S. Patents By Country For Progressive Ataxia Syndromes, 2010-2012
Table 60 : Patent Shares By Country For Progressive Ataxia Syndromes, 2010-2012
Table 61 : U.S. Patents By Country For Progressive Weakness And Effect On The Brain And
Spinal Cord Syndromes, 2010-2012
Table 62 : Patent Shares By Country For Progressive Weakness And Effect On The Brain And
Spinal Cord Syndromes, 2010-2012
Table 63 : U.S. Patents For Progressive Ataxia Syndromes By Company, 2010-2012
Table 64 : U.S. Patents For Progressive Weakness And Effect On The Brain And Spinal Cord
Syndromes By Company, 2010-2012
Table 65 : Patents For Progressive Ataxia Syndromes By Assignee, 2010-2012
Table 66 : Patents For Progressive Weakness And Effect On The Brain And Spinal Cord
Syndromes By Assignee, 2010-2012
List Of Figures
Summary Figure : Global Market For Progressive Ataxia And Weakness Disorders, 2010-2017
Figure 1 : Global Revenues Of Drug Product For The Treatment Of Neurodegenerative
Dysfunctions, 2010-2017
Figure 2 : Market Share Of Drug Used For The Treatment Of Neurodegenerative Disorders By
Dysfunction, 2011
Figure 3 : Global Sales Of Drug Product For The Treatment Of Progressive Ataxia And Weakness
Disorders, 2010-2017
Figure 4 : Market Share Of Drug Products For The Treatment Of Progressive Ataxia And
Weakness Disorders, 2011
Figure 5 : Market For Drug Products For The Treatment Of Progressive Ataxia And Weakness
Disorders By Region, 2010-2017
Figure 6 : Market Share Of Drug Products For The Treatment Of Progressive Ataxia And
Weakness Disorders By Region, 2011
Figure 7 : Global Sales Of Drug Products For The Treatment Of Progressive Ataxia And
Weakness Disorders By Technology, 2010-2017
Figure 8 : Market Share Of Drug Products For The Treatment Of Progressive Ataxia And
Weakness Disorders By Technology, 2011
Figure 9 : Sales Of Drug Products For The Treatment Of Progressive Ataxia By Disease Type,
2010-2017
Figure 10 : Progressive Ataxia Drug Market By Disease Type, 2011

9. Figure 11 : Progressive Ataxia Drug Market By Region, 2010-2017
Figure 12 : Progressive Ataxia Drug Market By Region, 2011
Figure 13 : Friedreich’s Ataxia Drug Market By Region, 2010-2017
Figure 14 : Gertsmann-Straussler-Scheinker Disease Drug Market By Region, 2010-2017
Figure 15 : Machado-Joseph Disease Drug Market By Region, 2010-2017
Figure 16 : Progressive Ataxia Drug Market By Technology, 2010-2017
Figure 17 : Progressive Ataxia Drugs Share By Technology, 2011
Figure 18 : Market Shares Of Manufacturers And Distributors Of Friedreich’s Ataxia Drugs, 2011
Figure 19 : Market Shares Of Manufacturers And Distributors Of Gertsmann-Straussler-Scheinker
Disease Drugs, 2011
Figure 20 : Market Shares Of Manufacturers And Distributors Of Machado-Joseph Disease Drugs,
2011
Figure 21 : Progressive Weakness Syndrome Drug Market By Disease Type, 2010-2017
Figure 22 : Progressive Weakness Drug Market By Disease Type, 2011
Figure 23 : Progressive Weakness Syndrome Drug Market By Region, 2010-2017
Figure 24 : Progressive Weakness Drug Market By Region, 2011
Figure 25 : Amyotrophic Lateral Sclerosis Drug Market By Region, 2010-2017
Figure 26 : Progressive Bulbar Palsy Drug Market By Region, 2010-2017
Figure 27 : Hereditary Spastic Paraplegia Drug Market By Region, 2010-2017
Figure 28 : Hereditary Neuropathy Drug Market By Region, 2010-2017
Figure 29 : Multiple Sclerosis Drug Market By Region, 2010-2017
Figure 30 : Progressive Weakness Syndrome Drug Market By Technology, 2010-2017
Figure 31 : Progressive Weakness Market By Technology, 2011
Figure 32 : Multiple Sclerosis Drug Market By Technology, 2010-2017
Figure 33 : Multiple Sclerosis Drug Market Distribution By Technology, 2011
Figure 34 : Market Shares Of Manufacturers And Distributors Of Amyotrophic Lateral Sclerosis
Drugs, 2011
Figure 35 : Market Shares Of Manufacturers And Distributors Of Progressive Bulbar Palsy Drugs,
2011
Figure 36 : Market Shares Of Manufacturers And Distributors Of Hereditary Spastic Paraplegia
Drugs, 2011
Figure 37 : Market Shares Of Manufacturers And Distributors Of Hereditary Neuropathy Drugs,
2011
Figure 38 : Market Shares Of Manufacturers And Distributors Of Multiple Sclerosis, Drugs 2011
Figure 39 : Number Of Patents By Year, 2010–March 2012
Figure 40 : Patents By Disease Category, 2010–March 2012
Figure 41 : Patents For Progressive Ataxia Syndromes By Disease Type, 2010–2012
Figure 42 : Patents For Progressive Weakness And Effect On Brain And Spinal Cord Syndromes
By Disease Type, 2010–2012
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