Immunocytokines are defined as the category of molecules made by linking tumor-reactive monoclonal antibodies with cytokines leading to activation of immune cells. This molecule is majorly used to treat tumors as tumor selective localization is possible due to ability of molecular antibodies element to bind with molecules on tumor cell surface or molecule activating immune cells with appropriate receptors. The market for the immunocytokines is majorly classified into three segments, on the basis of disease condition, targeting sites and clinical trials. Based on disease conditions, the immunocytokines market is divided into three classes namely cancer and tumor, rheumatoid arthritis and others. On the basis of targeting sites, the market is divided into following segments:
Liver
Bone marrow endothelium
Hypothalamus
Fat muscle
B and T lymphocytes
For several years, the development of new cytokines was stagnated majorly because of dose-limiting toxicities. However, the recent research and development activities combined with engineering of cytokines have lead to the introduction of new molecular entities with better safety and tolerability. Immunocytokines field is currently undergoing clinical trials and the major clinical progress made with immunocytokines is linked with human interlukin-2 to select number of tumor reactive molecular antibodies. Major research and clinical trials performed in immunocytokines market majorly consist of following categories:
Immunocytokines with tumor necrosis factor
Immunocytokines with first generation Interleukin-2
Immunocytokines with second generation Interleukin-2
Immunocytokines with Interleukin-10
Immunocytokines with Interleukin-12
Immunocytokines with Interleukin-15
Immunocytokines with Interferon
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Immunocytokines Market Growth, Trends in 2013 And Forecast for 2019
1. Immunocytokines Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2019
Immunocytokines are defined as the category of molecules made by linking tumor-reactive monoclonal antibodies with cytokines leading to activation of
immune cells. This molecule is majorly used to treat tumors as tumor selective localization is possible due to ability of molecular antibodies element to bind with
molecules on tumor cell surface or molecule activating immune cells with appropriate receptors. The market for the immunocytokines is majorly classified into
three segments, on the basis of disease condition, targeting sites and clinical trials. Based on disease conditions, the immunocytokines market is divided into three
classes namely cancer and tumor, rheumatoid arthritis and others. On the basis of targeting sites, the market is divided into following segments: Liver Bone
marrow endothelium Hypothalamus Fat muscle B and T lymphocytes For several years, the development of new cytokines was stagnated majorly because of
dose-limiting toxicities. However, the recent research and development activities combined with engineering of cytokines have lead to the introduction of new
molecular entities with better safety and tolerability. Immunocytokines field is currently undergoing clinical trials and the major clinical progress made with
immunocytokines is linked with human interlukin-2 to select number of tumor reactive molecular antibodies. Major research and clinical trials performed in
immunocytokines market majorly consist of following categories: Immunocytokines with tumor necrosis factor Immunocytokines with first generation
Interleukin-2 Immunocytokines with second generation Interleukin-2 Immunocytokines with Interleukin-10 Immunocytokines with Interleukin-12
Immunocytokines with Interleukin-15 Immunocytokines with Interferon The companies, which are targeting tumor sites with the help of immunocytokines in
the market, have mentioned certain important information in their project description. The information which is listed includes drug codes, mechanism of action,
class of compound, company, product category, indication and research and development stage. The in-vivo performance of immunocytokines crucially depends
upon some of the molecular determinants namely molecular format, target antigen and valence, which is also mentioned in project details. Merck KGaA was the
first company involved in research with immunocytokines and started with DI-Leu16-IL2, intellectual property owned by Merck KGaA. The company is
currently involved in development of two new immunocytokines based on antibody targets and these immunocytokines are validated for high level expression in
their respective cancer type. These include metastic melanoma, targeting CSPG4 and prostate cancer, EpCAM is targeted molecule as initial disease indication.
The research has been performed on these molecules so that they could be useful for other cancers expressing same target.
Large number of companies across Europe and North America are performing clinical trials on immunocytokines driven by higher prevalence of cancer in the
region. The pharmaceutical companies based in Asia-Pacific region are also showing growth in this market majorly due to growing government support towards
research and development in healthcare sectors in countries such as Japan, India, Malaysia and China. Substantial side effects and unfavorable pharmacokinetic
properties are the major restraints which the companies will face, hampering the administration of therapeutically relevant doses.
Some of the key players involved in clinical trials in the market of immunocytokines are Alkermes Plc, Alopexx Oncology, Altor Biosciences Corporation,
Apeiron Biologics AG, AstraZeneca Plc, CytImmune, Cytune Pharma, ImmunGene, Inc., Immunomedics, Inc., Merck KGaA, MolMed S.p.A., Nektar
Therapeutics, Paladin Labs, Pfizer, Inc., F. Hoffmann-La Roche, Ltd., Targa Therapeutics Corporation, Teva Pharmaceutical Industries Ltd. and Valor
Biotherapeutics.
This research report analyzes this market depending on its market segments, major geographies, and current market trends. Geographies analyzed under this
research report include North America Asia Pacific Europe Rest of the World This report provides comprehensive analysis of Market growth drivers
Factors limiting market growth Current market trends Market structure Market projections for upcoming years This report is a complete study of current trends
in the market, industry growth drivers, and restraints. It provides market projections for the coming years. It includes analysis of recent developments in
technology, Porter’s five force model analysis and detailed profiles of top industry players. The report also includes a review of micro and macro factors
essential for the existing market players and new entrants along with detailed value chain analysis.
Reasons for Buying this Report This report provides pin-point analysis for changing competitive dynamics It provides a forward looking perspective on
different factors driving or restraining market growth It provides a six-year forecast assessed on the basis of how the market is predicted to grow It helps in
understanding the key product segments and their future It provides pin point analysis of changing competition dynamics and keeps you ahead of competitors It
helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments It provides distinctive
graphics and exemplified SWOT analysis of major market segments
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Immunocytokines Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2019