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- 1. Sex, Drugs and Rock’n’Roll A Secret Tale of Parkinsons Disease
- 5. Dopamine pathways in human brain
Notes de l'éditeur
- The ventral tegmental area (VTA) cells project to limbic (mesolimbic projection) and cortical (mesocortical projection) areas. Neurons of the substantia nigra project to the striatum (nigrostriatal projection). In PD, dopaminergic nerve cells in the substantia nigra develop nerve cell loss, and its degeneration and the resulting striatal dopamine depletion are responsible for most of the motor abnormalities.
- Clinically, PD is characterized by three cardinal symptoms: resting tremor, bradykinesia (generalized slowness of movements) and muscle rigidity.
- PD is the most common movement disorder affecting 1-2 % of the general population over the age of 65 years, and it is the second most common neurodegenerative disorder after Alzheimer´s disease (AD). Tanner, CM et al. Epidemiology and genetics of Parkinson´s disease. In: Watts RL, Koller WC, ed. Movement Disorders, Neurologic principles and practice. New York: McGrawhill, pp. 137-152, 1997 .