fast dispersible tablets,reprimelts,mouth dissolving tablets.

1. PREPARATION AND EVALUATION OF MOUTH DISSOLVING TABLET Presented By: Under the guidance of: Sachin Mr. NarendraPandey

2. Contents Literature Review Introduction Promising drug candidates for MDT Popular Disintegrants used in MDT Techniques for MDT formulation Marketed Products of MDT Evaluation Future Planning 2

4. Shirsand S B, Suresh S, Para M S, Swamy P V, Kumar N D, Plantagoovata mucilage in the design of fast disintegrating tablets. Indian J. Pharm. Sci. 2009;41-46.

5. Gattani S. G, Shiyani B.G, KakadeK.N,Patil A.B, Surana S.J. Formulation and evaluation of mouth dissolving tablet of ondansetron hydrochloride by using superdisintegrants. Indian drugs. 2009; 46(1): 44-50.

6. Shoukri A R, Ahmed S I, Shamma N R. In vitro and in vivo evaluation of nimesulidelyohilized orally disintegrating tablets.Eur. J. Pharm. biopharm. 2009; 30: 1-10.

7. Goswami J P, Sharma S, Gupta G D. An effervescent and reproducible method for prepration of fast disintegrating tablets. Pharma Buzz. 2009; 4(3): 46-52.3

9. Shukla D, Chakraborty S, Singh S, Mishra B. Mouth dissolving tablets: An overview of Formuation technology. ScientiaPharmaceutica. 2009; 77: 309-326.

10. Fini A, Bergamante V, Ronchi C, Moraes F A C. Fast Dispersible/slow releasing ibuprofen tablets. Eur. J. Pharm. Biopharm. 2008; 69: 335-341.

11. Shah P P, Rajashree C M. Formulation and evaluation of primaquine phosphate taste- masked rapidly disintegrating tablet. J. Pharm. Pharmcol. 2008; 60: 1279-1285.

12. Rashid I, Remawi A M, Eftaiha A A,BadwanA.Chitin –Silicon Dioxide coprecipitate as a novel superdisintegrant. Indian J. Pharm. Sci. 2008; 97(11): 4955-4969.

13. Patel D M, Patel M M..Optimization of etorocoxib tablets prepared by sublimation technique. Indian J. Pharm. Sci. 2008; 70(1): 71-76.

14. Chaudhri P.D, Chaudhari S.P, Lanke S.D, Patel N. Formulation and in vitro evaluation of taste masked orodispersible dosage form of levocetirizinedihydrochloride. Indian J. Pharm. Edu. Res. 2007; 41(4): 319-327.4

16. Qalaji R M M, Simons R E F, Simons J K. Fast-disintegrating sublingual epinephrine tablets: Effect of tablet dimension on tablet characteristics. Drug Dev. Ind. Pharm. 2007; 33: 523-530.

17. Shishu, AshimaB,Singh T. Preparation of tablets Rapidly disintegrates in the saliva containing bitter taste masked granules by compression method. Indian J. Pharm. Sci. 2007; 69(1):80-84.

18. Ciper M, Bodmeier R. Modified conventional hard gelatin capsules as fast disintegrating dosage form in the oral cavity. Eur. J. Pharm. biopharm. 2006; 62: 178-184.

19. Mizumoto T, Masuda Y, Yamamoto T, Yonemochi E, Terada K.formulation design of a novel fast-disintegrating tablet. Int. J. Pharm. 2005; 306: 83-90.

20. Valleri M, Mura P, Cirri M, Balllerini R. Development and evaluation of glyburide fast dissolving tablets using solid dispersion technique.Drug Dev. Ind. Pharm. 2004; 30(5): 525-534.5

22. USP and EP used the term ODT for the tablets that disperses readily and within 3 minutes in mouth before swallowing.

23. US-FDA defined ODT as “A solid dosage form containing medicinal substances or active ingredient which disintegrates rapidly usually with in a matter of seconds when placed on the tongue.”Shukla et al., Mouth Dissolving Tablet: An overview of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326. 6

25. Improved patient compliance

26. Beneficial for travelling patients

27. Bypass First pass metabolism

28. Benefit of both liquid and solid dosage formGopala et al., An Effective and Reproducible Method For Preparation Of Fast disintegrating tablet. Pharma Buzz. 2008; 3(9): 38-40 7

29. Promising drug candidates for MDT . 8 Sharma et. al. Mouth dissolving tablet : A Review. Pharma Buzz. 2009; 4(1): 30-41

30. Continued... 9

31. 10 Continued...

32. Popular Disintegrants used in MDT 11 Sharma et al., Mouth dissolving tablet: A review.Pharma Buzz.2009; 4(01): 30-41.

33. Continued... 12

34. Mechanism of action of superdisintegrants 13 Sharma et al., Mouth dissolving tablet: A review.Pharma Buzz.2009; 4(01): 30-41.

35. Techniques for MDT formulation Lyophilisation Moulding Direct compression Cotton candy process Spray drying Sublimation Mass extrusion Nanonization Fast dissolving films 14 Shukla et al., Mouth Dissolving Tablet: An overview of formulation technology. Sci. Pharm. 2009; 77: 309-326.

36. Sublimation technique for prepration of mdt 15 Sharma et al., Mouth dissolving tablet: A review.Pharma Buzz.2009; 4(01): 30-41.

37. 16 List of Patented Technology Based Branded Products Shukla et al., Mouth Dissolving Tablet: An overview of formulation technology. Sci. Pharm. 2009; 77: 309-326.

38. 17 Continued...

39. Marketed Products of MDT Sharma et al., Mouth dissolving tablet: A review. Pharma Buzz.2009; 4(01): 30-41. 18

41. Bulk density

42. Tapped density

43. Powder flow propertiesBhise et. al. Formulation and evaluation of fast disintegrating tablets of Diphenhydramine tannate. 2006; 1(1): 41-45. 19

45. Hardness And Friability

46. Tensile Strength

47. Wetting time and water absorption Ratio

48. Friability

49. Disintegration test

50. Dissolution test Terada et. al. Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose. Int. J. Pharm., 2006; 310: 101-109. 20

51. in vitro dispersion test 21 Kumar S R, Lakshmi S V P. Reprimelts: A novel approach in drug delivery systems.Pharma buzz. 2009; 4(7): 72-76

52. 22 Electroforce Disintegration Test Apparatus Shukla et. al ,Mouth Dissolving Tablet: An overview Of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326.

53. Disintegration test with rotary shaft method 23 Shukla et. al ,Mouth Dissolving Tablet: An overview Of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326.

54. Modified Dissolution Test Apparatus For Disintegration Test Shukla et al., Mouth Dissolving Tablet: An overview Of Evaluation Techniques. Sci. Pharm. 2009; 77: 309-326. 24

55. how mdt dissolves 25

57. Search for suitable and cheap superdisintegerant.

58. Select the feasible manufacturing technique

59. To make tablet which should disintegrate or dissolve in the mouth within a few seconds

60. To improve patient compliance

61. To allow high drug loading

62. To develop tablet with pleasing a mouth feel

63. To formulate MDT which will be compatible with taste masking and other excipients26

65. 28 “If we knew what we were doing it wouldn't be RESEARCH…” ---Albert Einstein