Strengths and Weaknesses

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Technologie Santé & Médecine

Strengths and Weaknesses Lisa Joseph Sophie Harris

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Result reliability/reproducibility? Itoh Y et al CHO-hGPR40 <300µM Briscoe CP et al HEK293-hGPR40 >1µM Kotarsky K et al HFF11-R10 ‘ appropriate’ Capric acid (C6) 43±2.2 4.85±0.06 12.6±0.4 γ -linolenic acid 4.6±1.6 5.05±0.12 28.5±2.6 Oleic acid 2.0±0.3 4.39 123.1±12

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1. The following are body mass index (BMI) scores measured in 12 patients who are free of diabetes and participating in a study of risk factors for obesity. Body mass index is measured as the ratio of weight in kilograms to height in meters squared. Generate a 95% confidence interval estimate of the true BMI. 25 27 31 33 26 28 38 41 24 32 35 40 2. Consider the data in Problem 1. How many subjects would be needed to ensure that a 95% confidence interval estimate of BMI had a margin of error not exceeding 2 units? 3. The mean BMI in patients free of diabetes was reported as 28.2. The investigator conducting the study described in Problem 1 hypothesizes that the BMI in patients free of diabetes is higher. Based on the data in Problem 1 is there evidence that the BMI is significantly higher that 28.2? Use a 5% level of significance. 4. Peak expiratory flow (PEF) is a measure of a patient’s ability to expel air from the lungs. Patients with asthma or other respiratory conditions often have restricted PEF. The mean PEF for children free of asthma is 306. An investigator wants to test whether children with chronic bronchitis have restricted PEF. A sample of 40 children with chronic bronchitis are studied and their mean PEF is 279 with a standard deviation of 71. Is there statistical evidence of a lower mean PEF in children with chronic bronchitis? Run the appropriate test at =0.05. 5. Consider again the study in Problem 4, a different investigator conducts a second study to investigate whether there is a difference in mean PEF in children with chronic bronchitis as compared to those without. Data on PEF are collected and summarized below. Based on the data, is there statistical evidence of a lower mean PEF in children with chronic bronchitis as compared to those without? Run the appropriate test at =0.05. Group Number of Children Mean PEF Std Dev PEF Chronic Bronchitis 25 281 68 No Chronic Bronchitis 25 319 74 6. Using the data presented in Problem 5, a) Construct a 95% confidence interval for the mean PEF in children without chronic bronchitis. b) How many children would be required to ensure that the margin of error in (a) does not exceed 10 units? 7. A clinical trial is run to investigate the effectiveness of an experimental drug in reducing preterm delivery to a drug considered standard care and to placebo. Pregnant women are enrolled and randomly assigned to receive either the experimental drug, the standard drug or placebo. Women are followed through delivery and classified as delivering preterm (< 37 weeks) or not. The data are shown below. Preterm Delivery Experimental Drug Standard Drug Placebo Yes 17 23 35 No 83 77 65 Is there a statistically significant difference in the proportions of women delivering preterm among the three treatment groups? Run the test at a 5% level of significance. 8. Using the data in Problem 7, generate a 95% confidence interval for the difference in proportions of women ...

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2.

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6. Result reliability/reproducibility? Itoh Y et al CHO-hGPR40 <300µM Briscoe CP et al HEK293-hGPR40 >1µM Kotarsky K et al HFF11-R10 ‘ appropriate’ Capric acid (C6) 43±2.2 4.85±0.06 12.6±0.4 γ -linolenic acid 4.6±1.6 5.05±0.12 28.5±2.6 Oleic acid 2.0±0.3 4.39 123.1±12

7.

8. Intracellular metabolism or GPR40? Poitout 2003

9.