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BORRELIA G.HARIPRASAD M.Sc.,(Med micro),M.phil., Lecturer in Microbiology  Department of Microbiology  Thoothukudi Govt. Medical College  Thoothukudi
Spirochaete with wide-opened coils  Stain easily with ordinary stains i.e. Gram stain Gram negative spiral rods  Some borrelia occur as mouth commensals
Species of medical concern ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Relapsing fever   ,[object Object],[object Object],[object Object],[object Object],TICK BODY LOUSE
Pathogenesis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Laboratory diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
TREATMENT   ,[object Object],[object Object],[object Object],[object Object],Prophylaxis   Control of vectors ( louse and tick)  Maintenance of good personal hygiene
Vincent’s angina  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Lab diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Fusiform rods
CULTURE ,[object Object],[object Object],[object Object],[object Object],[object Object]
LYME DISEASE   ,[object Object],[object Object],First case identified in Lyme, USA – hence the name “Lyme disease”
DEER - RESERVOIR IXODID TICK  Tick gets borrelia when feed deer’s blood BORRELIA
PATHOGENICITY
Erythema migrans – forms where tick bites TICK FEEDING ON HUMAN
DISSEMINATED INFECTION ,[object Object],[object Object],[object Object],[object Object],[object Object]
PERSISTENT INFECTION ,[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL MANIFESTATION
Laboratory diagnosis BLOOD SMEAR EXAMINATION AFTER GIEMSA STAINING DARK FIELD MICROSCOPY
FONTANA’S STAIN
Fluorescent microscopy Borrelia-specific antibody tagged with fluorescent dyes are added If borrelia binds with such antibodies, they can fluoresce like this!!!!!!!!!
CULTURE ,[object Object],[object Object],[object Object]
TREATMENT   ,[object Object],[object Object],[object Object],NO VACCINES !!!!!!!!!!!!

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Borrelia