1. Product Information Novel Kinase Inhibitors
for cell signaling & oncology research
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Technical Data:
Orders
M.Wt: 343.42
NC +1-713-922-4115
Formula: C20H25NO4 O enquiry@selleckchem.com
Solubility: DMSO
COOH Tech Support
Purity: 99% O H
tech@selleckchem.com
Storage: at -20℃ 2 years
(chemistry support)
CAS No.: 153259-65-5 Synonyms: Ariflo, SB-207499 techbio@selleckchem.com
(bio support)
Web
Biological Activity
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Cilomilast(SB-207499) is among the first of a new generation of PDE4 inhibitors (Ki ≈100 nM).
Cilomilast(SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency
(Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast(SB-207499)
is 100-fold less potent against HPDE4. This profile suggests that Cilomilast(SB-207499) retain
the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side
effects. [1]
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References
[1] MARY S. BARNETTE et al. JPET.1998,284(1):420-426
Return Policy
[2] Neil F. Badham et al. Org. Proc. Res. Dev. 2003,7(1):101-108
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