This is a presentation on the process of formulating customized cosmeceuticals.

1. Custom Cosmeceutical Formulations
Utilizing Medical Image Analysis and
Biometric Markers
Robert P. Manzo
Skinprint
1997 Rt 17M
Goshen, New York 10921
845-294-8501
www.skinprint.com

2. Background
Mass Customization and Personalization is now common
Automobiles
Clothing
Shoes
Cosmeceutical Technology & Diagnostics Have Converged
Skin diagnostics have become more user friendly
Medical imaging has become more accessible
Cosmetic active ingredients are efficacious
Consumers are more educated
Demographics are creating demand

3. 3 Types of PigmentationCosmeceutical
Customized/Personalized
Formulation
Imaging
.
High resolution macro photography
Color ultraviolet reflectance
A specific combination photography
of biometric
measurements and Epidermal Biometrics
imaging will yield
Hydration
optimal results in most pH
cases Elasticity & Firmness
TEWL (Barrier)
Sebum
Melanin and redness

4. Imaging Quantitative Markers
Wrinkles
Color tone
Stratum corneum texture
Hyper pigmentation root cause
Oxidative damage
Melasma
Post-inflammatory hyper pigmentation
Melanin banding patterns
Pore size
Bacterial presence (UV)
Determination of epidermal vs. dermal Melasma (UV)
Product occlusion
Lesion count

6. Subject with Melasma and minor oxidative damage
(sun damage)
Confidential

7. Subject with Melasma and minor oxidative
damage (sun damage) and melanin banding
Confidential

8. Bacterial presence

9. Bacterial presence

10. Product Occlusion
Confidential

11. Epidermal Biometrics
Hydration
Dose and type of moisturizing ingredient
pH
Bacterial proliferation (acne root cause)
Too many chemical peels (barrier function impairment)
Elasticity & Firmness
Type and dose of collagen and elastin initiators
Dose of MMP suppressors
TEWL (Barrier)
Humectant or occlusive moisturizer
Acne initiator
Sebum
Acne root cause
Melanin and redness
Baseline for in office procedures (lasers, peels, etc.)
Rosacea quantification
Healing rates

12. Case Study
46 year old subject
Self described issues
“spots” on face
Under eye darkness and puffiness
Chronic dryness
Skin laxicity
Medical History
Healthy, non-remarkable
Pre-menopausal
12 year use of Retin-A

13. Visible and UVCR Analysis

14. Subject Biometrics Before Treatment
Reading Optimal Range
•Hydration 38.0 >62
•pH 5.9 4.5 - 5.5
•Elasticity & Firmness 47.0 >60
•TEWL (Barrier) 9.0 <3
•Sebum 3.0 15 - 25
•Melanin 15 (spots = 36) 7 (spots = 22)
•redness 46 17

15. Treatment Course
Cleanser: anionic surfactant base for thorough cleansing
3 dimensional bio-peptide approach
Collagen I & III initiator
Fibril bundling strengthener
Matrix Metalloproteinase inhibitor
Two phase eye treatment approach
Capillary seal
Chelant for removal of iron (hemoglobin)
Three phase lightening approach
MSH suppressor
Tyramine competition
Tyrosinase inhibitor
Treatment Lotion
Liposomal ursolic acid (barrier repair)
Occlusive and humectant moisturizers

16. Results
Before After
Hydration 38.0 67.0
pH 5.9 5.3
Elasticity & Firmness 47.0 56.0
TEWL (Barrier) 9.0 2.0
Sebum 3.0 4*
Melanin 15 (spots = 36) 8 (spots = 25)
redness 46 17
Confidential

17. Results

18. Results

19. 1997 RT 17M
Goshen, New York 10924
845-294-8501
www.skinprint.com
Robert Manzo