What is Monograph ?

1. Monograph
By: YT/ Pharma Hotspot

2. Content
Introduction
Examples of monograph:-
Sodium citrate
Calcium carbonate
Copper Sulphate
Ammonium chloride
Ferrous Gluconate

3. Monograph
It contains detailed information of a drug substance and products,
including –
• Chemical name
• Appearance
• Solubility
• Assay
• Identification tests
• Storage conditions
• Impurities
• Moisture content.

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Examples of monograph
Sodium citrate
It is used as an Anticoagulant for whole blood
(as it chelates serum calcium)
Citrate are used to chelate other cations also
e.g., in benedicts solution it chelates Cu2+ . It is used as a buffering
agent and as a urine alkanizer. In combination with citric acid it can be
used to prevent gout and kidney stones.
It is prepared by reaction of sodium carbonate and citric acid.
Assay: Non aqueous titration using, 0.1N HClO4 as titrant and
1-naphtholbenzene solution as an indicator.

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Examples of monograph
Calcium Carbonate
• It is used as fast acting antacid,
Preparation:-
CaCl2 + Na2CO3 2NaCl + CaCO3( )
• Assay: Complexometric titration, using 0.05MEDTA as
titrant and calcon as an indicator.

6. Examples of monograph
Copper sulphate
It is used as an emetic. It is used as a germicide and
insecticide in agriculture. Bordeaux mixture (copper
sulphate and lime) is used as a fungicide.
Preparation:-
Cuo + H2SO4 CuSO4 + H2O

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Examples of monograph
Ammonium Chloride
• It is used as an expectorant.
• Preparation:-
NH3 + HCl NH4Cl
Assay: Indirect acid base titration, 0.1N NaOH as titrant and
phenolphathalein as indicator. Formaldehydemis added to
liberate HCl (hexamine is the side product).

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Examples of monograph
• Ferrous gluconate
It is used as an iron sourece in the treatment of various
types of anaemias.
• Assay: Oxidation-reduction titration, using 0.1N ceric ammonium
sulphate

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