Marijn Dekkers, GCF2012 presentation, An apple a day is no longer enough

1. GCF 2012 “ The Entrepreneurship Imperative” 21-24 January 2012 Dr. Marijn Dekkers Chairman of the Board of Management of Bayer AG An Apple A Day Is No Longer Enough?

2. Aging Population – In This Respect We Are Getting Healthier Source: OECD Increase of global average life expectancy Percent of global population aged 65 years+ Source: OECD

3. We Are Getting Healthier – Pharma Industry Contributions Source: IMS World Review, 1980-2010 *non-currency-adj. Pharma Industry with steady sales growth CAGR + 9 % Number of FDA-approved new pharmaceutical drugs Pharma Industry R&D–output on high level Adapted from: Munos, Lessons from 60 years of pharmaceutical innovation, Nature Reviews, December 2009. Global audited pharmaceutical drug sales* US$ bn *non-currency-adjusted

4. Source: The Global Burden Of Chronic Diseases, JAMA 2004 – Source derived from data in World Health Report 2003 *Chronic Obstructive Pulmonary Disease **Non-Communicable Diseases 0 10 20 30 40 50 60 1990 2002 2020 Cardiovascular Diseases Other NCD** COPD*, Asthma Diabetes Mellitus Chronic Illness – Global mortality vs. growth of world population Cancer At The Same Time Increase Of NCDs – Change Of Lifestyle 0 50 100 150 200 250 1963 1973 1983 1993 2003 Mio. t developing countries industrialized countries Source: faostat.fao.org Increase of global meat production NCDs +2% CAGR World population +1% CAGR No. of deaths mio.

5. Parallel Effect: Improved Diagnostics – More NCDs Diagnosed Computed Tomography exams USA, total Magnetic Resonance Imaging exams USA, total Number in Mio Source: OECD

8. Rising R&D Expenditures – Adequate Rewards? Source: FDA, PhRMA, Bank of Amerika Merrill-Lynch Global Research Worldwide R&D spending (indexed, 1996 = 100) FDA approvals new pharmaceutical drugs (indexed, 1996=100)

9. Dr. Marijn Dekkers Chairman of the Board of Management of Bayer AG