15. • Low sacral region –
a) Bowel & Bladder incontinence
b) Anesthesia in perianal region
c) No motor impairment
• Mid lumbar region –
a) Flaccid paralysis of lower limbs
b) Absence of DTR
c) No response to pain , touch
• Cervical/thoracic
No deficit
Cleft in hemisphere, microgyria, severe disabled, unilat--hemiparesis
asymptomatic- mc,paresis,,mr,fit, insult to commisural plate, pachygyria.
Familial. abnormalities of both the integument and central nervous system
100% present,>15mm –postpubertal,
Follobp,eye, scoliosis,cns assess
Eye ex, screen parent, gene tracing.
Hamartintuberin, affect skin,brainhtkidn,bone eye
Woods lamp
& phakoma,
Subependymal calcify
Nevus,fits,hemiparesis,ic-calcification
anomalous development - primordial vascular bed - early stages of cerebral vascularization. leptomeninges are richly vascularized and the brain beneath becomes atrophic and calcified, particularly in the molecular layer of the cortex
