4. Smallpox
only infectious disease
to have been
eliminated by
vaccination
2 forms: variola major
(high mortality), variola
minor
Saturday, May 29, 2010
8. Characteristics
large, enveloped, icosahedral
encode DNA polymerase
latency, persistence
very common causes of infection
Saturday, May 29, 2010
9. HSV 1 and 2
HSV-1 more common in oral lesions; HSV-2 in genital
lesions
majority asymptomatic; skin and mucous membrane
lesions, encephalitis, keratitis
congenital infection
diagnosis: serology, culture
treatment: acyclovir and related drugs
Saturday, May 29, 2010
10. Herpes
simplex 1
and 2
2 different viruses related
to each other
latency in nerve ganglia
reactivation
Saturday, May 29, 2010
14. Varicella (chickenpox)
self-limiting; incubation 2 weeks
milder in children
severe in neonates whoe mothers had chickenpox <5
days prior to delivery, in adults and in
immunocompromised
diagnosis often clinical but can be cultured
treatment: acyclovir
Saturday, May 29, 2010
17. Epstein-Barr virus
infects B lymphocytes - receptor is complement
receptor on B cell
B cell infection leads to immortalization and polyclonal
B cell stimulation
transmitted thru saliva
causes infectious mononucleosis
possibility of inducing transformation
Saturday, May 29, 2010
21. EBV infection
has been associated with endemic type of Burkitt’s
lymphoma and nasopharyngeal carcinoma
no practical treatment with antiviral
Saturday, May 29, 2010
22. Cytomegalovirus
very common infection
most common cause of
congenital viral infection
and most common
infectious cause of
deafness
present in body fluids
asymptomatic;
pneumonia; disseminated
in immunocompromised
e.g. AIDS
Saturday, May 29, 2010
