2. CONTENT
• WHAT QUESTION DIDTHE STUDY ASK?
• ARETHE RESULTS OFTHE STUDYVALID (STEP 1)
• WHAT WERETHE RESULTS (STEP 2)
• APPLICABILITY OFTHE RESULTS ( STEP 3)
3.
4. WHAT QUESTION DIDTHE STUDY ASK?
CATEGORY ANSWER
POPULATION Children ( 2-6 years) with respiratory illnesses
INTERVENTION Using normal milk containing probiotic lactobacillus rhamnosus GG
COMPARISON Normal milk only
OUTCOME Primary : measure the respiratory symptoms improvement by using
probiotic GG milk
Secondary: measure the gastrointestinal symptoms improvement by
using probiotic GG milk
5. ARETHE RESULTS OFTHE STUDYVALID
Was the assignment of patients to treatment randomized?
7. ARETHE RESULTS OFTHE STUDYVALID
Was follow-up of patients sufficiently long and complete?
8. ARETHE RESULTS OFTHE STUDYVALID
Were patients analyzed in the groups which they were randomized?
9. ARETHE RESULTS OFTHE STUDYVALID
Were patients and clinician kept ‘blind’ to treatment?
yes, blinding both the clinician and children *parent* to the treatment.
10. ARETHE RESULTS OFTHE STUDYVALID
Were the groups treated equally, apart from the experimental treatment?
11. ARETHE RESULTS OFTHE STUDYVALID
Were the groups similar at the start of the trial?
15. Odd Ratio
REGARDINGTO PRIMARYOUTCOME ( RESPIRATORY SYMPTOMS )
GG group OR of 5.03
(95% CI 4.92-5.15 )
Significant and precise
Placebo group OR of 5.17
(95% CI 5.05-5.29)
Significant and precise
16. ARETHESEVALID, IMPORTANT RESULTS APPLICABLETO MY
PATIENTS?
Is our patient so different from those in the study that its results cannot apply ?
The patients in the study are similar to our patients, mainly similar Demographic and clinical
characteristics ( which the author provides)
So, we can apply the results in our setting
17. Is the treatment feasible in my setting ?
Milk containing probiotic Lactobacillus rhamnosus GG is available in our market
0000000
ARETHESEVALID, IMPORTANT RESULTS APPLICABLE
TO MY PATIENTS?
18. What are our patient’s potential benefits and harms form the therapy ?
Benefits
0
Harms
0
ARETHESEVALID, IMPORTANT RESULTS APPLICABLETO
MY PATIENTS?
19. What are our patients values and expectations for both the outcome we are
trying to prevent and the treatment that we are offering ?
Decrease respiratory symptoms as a primary outcome of the study, also decrease
gastrointestinal symptoms
Find an alternative method to decrease the illness with effectively with less side effects
and easy administration not like the chemical drugs
ARETHESEVALID, IMPORTANT RESULTS APPLICABLE
TO MY PATIENTS?
