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Radial
Nerve
Palsy

Clinical
features &

Diagnosis

Dr Subhakanta Mohapatra
IPGME&R,Kolkata.INDIA
Anatomy
Radial Nerve
• Largest branch of the brachial plexus
• Arises from the posterior cord of the
brachial plexus (C5–8)
• Mixed nerve
Course of Radial Nerve (RN) in the arm
• Sensory supply:
In the axilla, RN lies
Posterior cutaneous
anterior to subscapularis,
nerve of arm
teres major and LD

RN leaves the axilla via
the triangular space

• Motor supply:
long head of Triceps

It then comes to lie along
spiral groove on
posterior aspect of
humeral shaft along with
arteria profunda brachii

• Motor: medial and lateral
heads of triceps, Anconeus
• Sensory: posterior
cutaneous nerve of forearm,
lower lateral cutaneous
nerve of arm
RN then leaves the spiral groove
by piercing the lateral
intermuscular septum to enter
the anterior compartment of the
arm, 10-12 cm above the lateral
epicondyle

• Motor supply: Brachialis (lateral
part), BR, ECRL
Here it lies b/w brachialis and
BR

• Terminal branches:
Posterior Interosseous
Anterior to lateral epicondyle, RN
Nerve (PIN) and Dorsal
divides into its terminal branches
or Superficial radial
sensory nerve
Radial nerve (C5, 6, 7 , 8, T1)
exiting axilla via the
triangular space

Triceps brachii
Radial nerve in the spiral
groove (posterior aspect of
humeral shaft)
Posterior cutaneous nerve of
arm

Lower lateral cutaneous
nerve of arm

Lateral intermuscular
septum
Brachialis (lateral part)
ECRL (last branch of radial
nerve proper)

Brachioradialis (BR)
Posterior cutaneous nerve of
forearm

Anconeus
Course of Radial Nerve (RN) in the forearm
Dorsal digital nerves

ECRL
Dorsal Radial Sensory
Nerve

BR

8 cm

Radial styloid
It crosses the
anatomical snuffbox
b/w EPB and EPL,
dividing into multiple
branches to supply
sensation to hand

It emerges b/w
tendons of BR and
ECRL ≈ 8 cm proximal
to radial styloid, to
become subcutaneous

Dorsal radial nerve
courses through the
forearm immediately
deep to the BR
Radial Nerve Proper
Superficial terminal branch
Deep terminal branch →
Posterior interosseous
nerve (PIN)
PIN reaches the back of
forearm by passing around
the lateral aspect of the
radius b/w the superficial
and deep heads of the
Supinator to supply all
extensor compartment
muscles

Supinator
ECRB
ECU
EDC and EDM

EIP
APL

Finally, PIN ends by
supplying carpal joint
sensation

EPL
EPB
Cutaneous innervation from radial nerve

Lower lateral cutaneous
nerve of arm
Posterior cutaneous nerve
of arm

Gives sensibility to the dorsum
of the hand over the radial twothirds, the dorsum of the
thumb, and the index, long, and
half of the ring finger proximal
to the distal interphalangeal
joint.

Posterior cutaneous nerve
of forearm

Dorsal radial sensory nerve
Clinical Features
Functional motor deficit
Inability to extend the wrist (in
case of injury at level of PIN, wrist
extension is weak with radial
deviation since ECRL innervation
is intact)

Inability to extend and radially
abduct the thumb

Weakness of grip strength d/t loss
of mechanical advantage that
wrist extension provides for grasp
and power grip

Inability to extend the fingers at
the MCP joints
Sensory Loss
Unlike the median and ulnar
nerves, sensory loss following
radial nerve injury is not
functionally disabling unless the
patient develops a painful
neuroma

Area of sensory loss in
radial nerve injury in the
axilla

The Lateral cutaneous nerve of
forearm has a significant
overlap pattern with the
Superficial radial sensory nerve

Autonomous sensory zone for
radial nerve → dorsum of 1st
webspace
Radial Nerve
Compression
Syndromes
Wartenberg’s syndrome

• Aka: Cheiralgia paresthetica
• D/t compression of Superficial radial nerve as it
emerges b/w ECRL and BR, 8 cm proximal to radial
styloid
presence of motor weakness
suggests a more proximal site of
compression

isolated pain or paresthesias
over the dorsoradial aspect of
the hand

preceding history of trauma to
the area (i.e., handcuffs,
forearm fracture)

Clinical features

Differentiating Wartenberg’s
syndrome from de Quervain’s
tenosynovitis
In WS, pain is exacerbated by pronation, while in DQT pain
is elicited with changes in thumb and wrist position
DQT - normal sensation in the dorso-radial hand
DQT - pain on percussion over the 1st extensor
compartment

Also seen in patients who use
forearms in pronated position
for extended periods → in
pronation, the tendons of BR
and ECRL approximate and may
compress the nerve

A Tinel’s sign over the
superficial sensory radial nerve
is the most common exam
finding
Electrodiagnostic testing is of
limited value in Wartenberg’s
syndrome
Posterior interosseous nerve (PIN) syndrome
• D/t compression of PIN in the radial tunnel
• Most common causes include:
Tumors such as lipomas, ganglia
Rheumatoid synovitis
Septic arthritis
Vasculitis
PIN

BR
arcade of Fröhse

The radial tunnel is a 5 cm space
bounded by:
Dorsally: capsule of the
radiocapitellar joint
Volarly: the BR
Laterally: the ECRL and ECRB
muscles
Medially: the biceps tendon and
brachialis muscles

Supinator
ECRL

Within radial tunnel, there are 5
potential sites of compression:
fibrous bands to the
radiocapitellar joint between the
brachialis and BR
the recurrent radial vessels (leash
of Henry)
the proximal edge of the ECRB
the proximal edge of the
Supinator (arcade of Fröhse)
the distal edge of the Supinator
Diagnosis
loss of finger and thumb extension
Weak wrist extension with radial deviation
(since ECRL innervation is intact)
Intact passive tenodesis effect
(rules out extensor tendon rupture)

EMG testing is helpful to confirm the diagnosis and
monitor motor recovery
Radial Tunnel syndrome

• Similar to PIN syndrome, it is also d/t compression of
PIN in the radial tunnel

• Not considered a true compression neuropathy by
some
Radial Tunnel Syndrome is a clinical diagnosis

Pain at ECRB origin
with resistance of
middle finger
extension

Tenderness over
radial tunnel
(lateral proximal
forearm, 3-4 cm distal
to lateral epicondyle
over the mobile wad)

Pain with resisted
forearm supination

↑ Pain on combined
elbow extension,
forearm pronation,
and wrist flexion

Radial Tunnel
Syndrome
Proximal Radial nerve compression

• Compression of the radial nerve proximal to the elbow is
uncommon
• Causes:
Fibrous arch from the lateral head of triceps
After strenuous muscular activity
Bony exostosis of humerus
Injury in spiral groove:
# shaft humerus
‘Saturday night palsy’ (neuropraxia)
Post injection palsy (chemical neurotmesis)
• Patients present with variable degrees of radial nerve
dysfunction
Diagnosis
History

Mechanism of injury (e.g. sharp penetrating vs.
blunt trauma)
Timing of injury

Loss of motor and sensory function

Presence of pain
Interval recovery of function in patients presenting
late
Physical
Examination

Individual muscles innervated by the
nerve are tested to determine what is
functioning and what is not:
Helps to determine the level of injury
Guides future surgical planning

Assessment of motor function

Assessment of sensory function

Elicitation of Tinel’s sign
Specific sensory testing

Assessment of involved joints
Each joint is taken through its passive
range of motion to assess for
suppleness → presence of fixed joint
contractures in delayed presentations
is associated with poor treatment
outcomes
Specific sensory tests
Test

Perception

Main receptor

Comments

Static 2 point
discrimination (2PD)

Tactile

Merkel cell

Evaluates sensory
receptor innervation
density
Normal distance: 6mm

Moving 2PD

Tactile

Meissner corpuscle

Tuning fork (250 Hz)

Vibration

Pacinian corpuscle

Tuning fork (30 Hz)

Vibration

Meissner

Semmes-Weinstein
monofilament test

Pressure

Merkel

Ten test (moving light
touch)

Pressure

Merkel

Cold-heat test

Temperature

Free nerve endings

Normal distance: 3mm

Reliability comparable
to monofilament test

•Changes in Vibration and Pressure thresholds are seen in early nerve compression but are unreliable for
evaluating nerve lacerations
•Changes in sensory receptor innervation density (2PD) are seen in chronic nerve compression but are reliable for
evaluating nerve lacerations
Electrodiagnostic
testing
Electromyography (EMG)

Helpful in arriving at a diagnosis
in presence of atypical
presentations or equivocal clinical
findings

Nerve conduction studies
(NCS)

Limitations of EDT:
Evaluates only large myelinated
fibres → smaller axons conveying
pain and temperature are not
assessed
Changes in unmyelinated nerve
fibres, which are the first to be
affected in nerve compressions,
are not evaluated
Performing the test before 3-6
weeks post injury can give
inaccurate results
Very proximal or distal nerve
injuries are difficult to assess
Unreliable assessment of multilevel injuries
Examiner dependant
Nerve conduction studies (NCS)
2 electrodes are placed along the course of the
nerve. The first electrode stimulates the nerve to
fire, and the second electrode records the
generated action potential

Amplitude

• represents the size of the
response
• proportional to the number
of depolarizing axons in the
nerve

Latency

• the delay in response
following stimulation

Sensory nerve action potential
(SNAP)
• Response obtained when
the recording electrodes is
placed proximally along the
sensory nerve, toward the
spinal cord

Conduction velocity

Compound motor action
potential (CMAP)
• Response obtained when
the recording electrodes is
placed distally at the target
muscle
Electromyography (EMG)
Insertional activity

Fibrillation potentials
Fasciculations

Motor unit potentials
(MUPs)

• Activity observed when a needle
electrode is inserted into the muscle

• Seen when the muscle is at rest
• Absent in normal muscles

• Generated by the muscle during a
voluntary contraction
• Evaluates the integrity of neuromuscular junction
Sequence of events in nerve
compression
Focal demyelination

Axonal damage at the
compression site

Further axonal loss

Axonal sprouting producing
collateral re-innervation

Remyelination following
decompression

Associated Electrodiagnostic
findings
↑Latency
↓Nerve conduction velocity

↓SNAP
↓CMAP
↑Insertional activity
Fibrillation potentials and
fasciculations

’Giant’ MUPs

Normalization of NCV
Loss of ‘giant’ MUPs
Radial nerve palsy  clinical features and diagnosis

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Radial nerve palsy clinical features and diagnosis

  • 3. Radial Nerve • Largest branch of the brachial plexus • Arises from the posterior cord of the brachial plexus (C5–8) • Mixed nerve
  • 4. Course of Radial Nerve (RN) in the arm • Sensory supply: In the axilla, RN lies Posterior cutaneous anterior to subscapularis, nerve of arm teres major and LD RN leaves the axilla via the triangular space • Motor supply: long head of Triceps It then comes to lie along spiral groove on posterior aspect of humeral shaft along with arteria profunda brachii • Motor: medial and lateral heads of triceps, Anconeus • Sensory: posterior cutaneous nerve of forearm, lower lateral cutaneous nerve of arm
  • 5. RN then leaves the spiral groove by piercing the lateral intermuscular septum to enter the anterior compartment of the arm, 10-12 cm above the lateral epicondyle • Motor supply: Brachialis (lateral part), BR, ECRL Here it lies b/w brachialis and BR • Terminal branches: Posterior Interosseous Anterior to lateral epicondyle, RN Nerve (PIN) and Dorsal divides into its terminal branches or Superficial radial sensory nerve
  • 6. Radial nerve (C5, 6, 7 , 8, T1) exiting axilla via the triangular space Triceps brachii Radial nerve in the spiral groove (posterior aspect of humeral shaft) Posterior cutaneous nerve of arm Lower lateral cutaneous nerve of arm Lateral intermuscular septum Brachialis (lateral part) ECRL (last branch of radial nerve proper) Brachioradialis (BR) Posterior cutaneous nerve of forearm Anconeus
  • 7. Course of Radial Nerve (RN) in the forearm Dorsal digital nerves ECRL Dorsal Radial Sensory Nerve BR 8 cm Radial styloid It crosses the anatomical snuffbox b/w EPB and EPL, dividing into multiple branches to supply sensation to hand It emerges b/w tendons of BR and ECRL ≈ 8 cm proximal to radial styloid, to become subcutaneous Dorsal radial nerve courses through the forearm immediately deep to the BR
  • 8. Radial Nerve Proper Superficial terminal branch Deep terminal branch → Posterior interosseous nerve (PIN) PIN reaches the back of forearm by passing around the lateral aspect of the radius b/w the superficial and deep heads of the Supinator to supply all extensor compartment muscles Supinator ECRB ECU EDC and EDM EIP APL Finally, PIN ends by supplying carpal joint sensation EPL EPB
  • 9. Cutaneous innervation from radial nerve Lower lateral cutaneous nerve of arm Posterior cutaneous nerve of arm Gives sensibility to the dorsum of the hand over the radial twothirds, the dorsum of the thumb, and the index, long, and half of the ring finger proximal to the distal interphalangeal joint. Posterior cutaneous nerve of forearm Dorsal radial sensory nerve
  • 11. Functional motor deficit Inability to extend the wrist (in case of injury at level of PIN, wrist extension is weak with radial deviation since ECRL innervation is intact) Inability to extend and radially abduct the thumb Weakness of grip strength d/t loss of mechanical advantage that wrist extension provides for grasp and power grip Inability to extend the fingers at the MCP joints
  • 12. Sensory Loss Unlike the median and ulnar nerves, sensory loss following radial nerve injury is not functionally disabling unless the patient develops a painful neuroma Area of sensory loss in radial nerve injury in the axilla The Lateral cutaneous nerve of forearm has a significant overlap pattern with the Superficial radial sensory nerve Autonomous sensory zone for radial nerve → dorsum of 1st webspace
  • 14. Wartenberg’s syndrome • Aka: Cheiralgia paresthetica • D/t compression of Superficial radial nerve as it emerges b/w ECRL and BR, 8 cm proximal to radial styloid
  • 15. presence of motor weakness suggests a more proximal site of compression isolated pain or paresthesias over the dorsoradial aspect of the hand preceding history of trauma to the area (i.e., handcuffs, forearm fracture) Clinical features Differentiating Wartenberg’s syndrome from de Quervain’s tenosynovitis In WS, pain is exacerbated by pronation, while in DQT pain is elicited with changes in thumb and wrist position DQT - normal sensation in the dorso-radial hand DQT - pain on percussion over the 1st extensor compartment Also seen in patients who use forearms in pronated position for extended periods → in pronation, the tendons of BR and ECRL approximate and may compress the nerve A Tinel’s sign over the superficial sensory radial nerve is the most common exam finding Electrodiagnostic testing is of limited value in Wartenberg’s syndrome
  • 16. Posterior interosseous nerve (PIN) syndrome • D/t compression of PIN in the radial tunnel • Most common causes include: Tumors such as lipomas, ganglia Rheumatoid synovitis Septic arthritis Vasculitis
  • 17. PIN BR arcade of Fröhse The radial tunnel is a 5 cm space bounded by: Dorsally: capsule of the radiocapitellar joint Volarly: the BR Laterally: the ECRL and ECRB muscles Medially: the biceps tendon and brachialis muscles Supinator ECRL Within radial tunnel, there are 5 potential sites of compression: fibrous bands to the radiocapitellar joint between the brachialis and BR the recurrent radial vessels (leash of Henry) the proximal edge of the ECRB the proximal edge of the Supinator (arcade of Fröhse) the distal edge of the Supinator
  • 18. Diagnosis loss of finger and thumb extension Weak wrist extension with radial deviation (since ECRL innervation is intact) Intact passive tenodesis effect (rules out extensor tendon rupture) EMG testing is helpful to confirm the diagnosis and monitor motor recovery
  • 19. Radial Tunnel syndrome • Similar to PIN syndrome, it is also d/t compression of PIN in the radial tunnel • Not considered a true compression neuropathy by some
  • 20. Radial Tunnel Syndrome is a clinical diagnosis Pain at ECRB origin with resistance of middle finger extension Tenderness over radial tunnel (lateral proximal forearm, 3-4 cm distal to lateral epicondyle over the mobile wad) Pain with resisted forearm supination ↑ Pain on combined elbow extension, forearm pronation, and wrist flexion Radial Tunnel Syndrome
  • 21. Proximal Radial nerve compression • Compression of the radial nerve proximal to the elbow is uncommon • Causes: Fibrous arch from the lateral head of triceps After strenuous muscular activity Bony exostosis of humerus Injury in spiral groove: # shaft humerus ‘Saturday night palsy’ (neuropraxia) Post injection palsy (chemical neurotmesis) • Patients present with variable degrees of radial nerve dysfunction
  • 23. History Mechanism of injury (e.g. sharp penetrating vs. blunt trauma) Timing of injury Loss of motor and sensory function Presence of pain Interval recovery of function in patients presenting late
  • 24. Physical Examination Individual muscles innervated by the nerve are tested to determine what is functioning and what is not: Helps to determine the level of injury Guides future surgical planning Assessment of motor function Assessment of sensory function Elicitation of Tinel’s sign Specific sensory testing Assessment of involved joints Each joint is taken through its passive range of motion to assess for suppleness → presence of fixed joint contractures in delayed presentations is associated with poor treatment outcomes
  • 25. Specific sensory tests Test Perception Main receptor Comments Static 2 point discrimination (2PD) Tactile Merkel cell Evaluates sensory receptor innervation density Normal distance: 6mm Moving 2PD Tactile Meissner corpuscle Tuning fork (250 Hz) Vibration Pacinian corpuscle Tuning fork (30 Hz) Vibration Meissner Semmes-Weinstein monofilament test Pressure Merkel Ten test (moving light touch) Pressure Merkel Cold-heat test Temperature Free nerve endings Normal distance: 3mm Reliability comparable to monofilament test •Changes in Vibration and Pressure thresholds are seen in early nerve compression but are unreliable for evaluating nerve lacerations •Changes in sensory receptor innervation density (2PD) are seen in chronic nerve compression but are reliable for evaluating nerve lacerations
  • 26. Electrodiagnostic testing Electromyography (EMG) Helpful in arriving at a diagnosis in presence of atypical presentations or equivocal clinical findings Nerve conduction studies (NCS) Limitations of EDT: Evaluates only large myelinated fibres → smaller axons conveying pain and temperature are not assessed Changes in unmyelinated nerve fibres, which are the first to be affected in nerve compressions, are not evaluated Performing the test before 3-6 weeks post injury can give inaccurate results Very proximal or distal nerve injuries are difficult to assess Unreliable assessment of multilevel injuries Examiner dependant
  • 27. Nerve conduction studies (NCS) 2 electrodes are placed along the course of the nerve. The first electrode stimulates the nerve to fire, and the second electrode records the generated action potential Amplitude • represents the size of the response • proportional to the number of depolarizing axons in the nerve Latency • the delay in response following stimulation Sensory nerve action potential (SNAP) • Response obtained when the recording electrodes is placed proximally along the sensory nerve, toward the spinal cord Conduction velocity Compound motor action potential (CMAP) • Response obtained when the recording electrodes is placed distally at the target muscle
  • 28. Electromyography (EMG) Insertional activity Fibrillation potentials Fasciculations Motor unit potentials (MUPs) • Activity observed when a needle electrode is inserted into the muscle • Seen when the muscle is at rest • Absent in normal muscles • Generated by the muscle during a voluntary contraction • Evaluates the integrity of neuromuscular junction
  • 29. Sequence of events in nerve compression Focal demyelination Axonal damage at the compression site Further axonal loss Axonal sprouting producing collateral re-innervation Remyelination following decompression Associated Electrodiagnostic findings ↑Latency ↓Nerve conduction velocity ↓SNAP ↓CMAP ↑Insertional activity Fibrillation potentials and fasciculations ’Giant’ MUPs Normalization of NCV Loss of ‘giant’ MUPs