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Overview of Research Yvonne Lee Yin Leng, MPH  Clinical Epidemiology Unit, CRC
What is research? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
How to answer the questions? ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Definition
[object Object],[object Object],[object Object],[object Object],[object Object],Type of research
Basic Biomedical Research  ,[object Object],[object Object],[object Object]
Epidemiological Research ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Health services research ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Methodological Research  ,[object Object],[object Object],[object Object]
Clinical Research / Clinical Epidemiology  ,[object Object],[object Object],[object Object],[object Object]
Types of Clinical Research Patient comes to see a clinician Task: to make right diagnosis 1.Diagnostic studies 2.Taxonomic study  3. Validation studies Patient given  Rx Task: to find most effective Rx ( good outcome)  1.Intervention  studies / RCT  2. Outcomes studies  Patient told  prognosis Task: to predict  a prognosis  1.Prognostic  studies / prediction rules
Summary of How Research Works (adapted from Hulley et al 2001) RESEARCH QUESTION TARG RESEARCH QUESTION TARG ,[object Object],[object Object],Step1
Summary of How Research Works (adapted from Hulley et al 2001) RESEARCH QUESTION TARG TARG STUDY PLAN  TARG ,[object Object],[object Object],[object Object],design RESEARCH QUESTION TARG ,[object Object],[object Object],Random & systematic Error  Step1 Step2 Step3 Step4
Summary of How Research Works (adapted from Hulley et al 2001) RESEARCH QUESTION TARG TARG TARG STUDY PLAN  TARG ,[object Object],[object Object],ACTUAL STUDY  TARG ,[object Object],[object Object],design RESEARCH QUESTION TARG ,[object Object],[object Object],conduct  Random & systematic Error  Random & systematic Error  design Random & systematic Error  Step1 Step2 Step3 Step4 Step5
Summary of How Research Works (adapted from Hulley et al 2001) RESEARCH QUESTION TARG TARG TARG STUDY PLAN  TARG ,[object Object],[object Object],[object Object],ACTUAL STUDY  TARG FINDINGS IN THE STUDY  ,[object Object],[object Object],design RESEARCH QUESTION TARG ,[object Object],[object Object],conduct  Random & systematic Error  Random & systematic Error  Data analysis  design conduct  design Step1 Step3 Step4 Step5 Step6 Step2
Summary of How Research Works (adapted from Hulley et al 2001) ,[object Object],[object Object],ACTUAL STUDY  RESEARCH QUESTION TARG TARG TARG STUDY PLAN  TARG TRUTH IN THE SAMPLE  ,[object Object],[object Object],ACTUAL STUDY  TARG FINDINGS IN THE STUDY  ,[object Object],[object Object],design RESEARCH QUESTION TARG ,[object Object],[object Object],conduct  Infer  Random & systematic Error  Random & systematic Error  Data analysis  RESEARCH QUESTION TARG TARG TARG STUDY PLAN  TARG ,[object Object],[object Object],[object Object],TARG design RESEARCH QUESTION TARG ,[object Object],[object Object],conduct  Random & systematic Error  Random & systematic Error  design conduct  design Step1 Step3 Step4 Step5 Step6 Step2
Summary of How Research Works (adapted from Hulley et al 2001) ACTUAL STUDY  ACTUAL STUDY  RESEARCH QUESTION TARG TARG TARG TRUTH IN THE POPULATION STUDY PLAN  TARG TRUTH IN THE SAMPLE  ,[object Object],[object Object],ACTUAL STUDY  TARG FINDINGS IN THE STUDY  ,[object Object],[object Object],design RESEARCH QUESTION TARG ,[object Object],[object Object],conduct  Infer  Infer  Random & systematic Error  Random & systematic Error  Data analysis  ,[object Object],[object Object],RESEARCH QUESTION TARG TARG TARG STUDY PLAN  TARG ,[object Object],[object Object],TARG ,[object Object],[object Object],design RESEARCH QUESTION TARG ,[object Object],[object Object],conduct  Random & systematic Error  Random & systematic Error  RESEARCH QUESTION TARG TARG TARG STUDY PLAN  TARG ,[object Object],[object Object],[object Object],TARG design RESEARCH QUESTION TARG ,[object Object],[object Object],conduct  Random & systematic Error  Random & systematic Error  design conduct  design Step1 Step3 Step4 Step5 Step6 Step2 Step6

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Research methology intro_ YL

  • 1. Overview of Research Yvonne Lee Yin Leng, MPH Clinical Epidemiology Unit, CRC
  • 2.
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  • 7.
  • 8.
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  • 11. Types of Clinical Research Patient comes to see a clinician Task: to make right diagnosis 1.Diagnostic studies 2.Taxonomic study 3. Validation studies Patient given Rx Task: to find most effective Rx ( good outcome) 1.Intervention studies / RCT 2. Outcomes studies Patient told prognosis Task: to predict a prognosis 1.Prognostic studies / prediction rules
  • 12.
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Notes de l'éditeur

  1. Undertaken in most professions More than a set of skills Way of thinking ; critical examine the various aspects of your work, understand how things work, developing and testing new theories to enhance your profession. Becomes a habit – a habit of questioning Questions can be raised about any professioons – as long as you either directly or indirectly provide service
  2. Informal Clinical impression/judgement Philosophy – higher aim – bring benefit to others. Positivenism and naturalnism Valid and reliable – measurements Unbiased and objective – no personal vested interest
  3. 2 syllables ; re – search , former – prefix – again, anew or over again Latter – verb – to examine closely and carefully, to test or try, or to probe
  4. The setting = Labs The subjects = human tissues/genes, specimens etc
  5. The setting = ideal population/community (house to house ) The subjects = community members Topics of study include describing new diseases, Descibe how diseases are spread (aetiology/risk factors) Decsribe methods to preventing the spread of disease, etc.
  6. There are health services researchers who conduct research on how health care is delivered to people. Topics of study include how health services are paid for, who does and does not get care, where people get care, what types of treatment are most effective, etc. In both instances, results of the research are used to develop health policy that seeks to protect and ensure the Public’s Health.
  7. rule discriminatory value of sign and symptom, diagnostic test accuracy study developing and validating new instrument eg risk factor modelling
  8. Think of 1 research question: Are patients satisfied with our OP counter-service? – target : patients who use OP in IPR, satisfaction level
  9. Intended sample : patients coming to OP IPR from jan- mac 2008, patients satisfaction scale questionnaire
  10. patients who consented PSSQ
  11. Internal validity Patients who consent are usually ‘good’ ones
  12. External validity/generalizibility Jan- mac : major renovation work that disrupt OP work flow