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Study Design   Yvonne Lee Yin Leng, MPH Clinical Epidemiology Unit, CRC
Study design
Common study design ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Purpose different study design ,[object Object],[object Object],[object Object],[object Object],[object Object]
Which study design?  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Research question ,[object Object],P atient  Doctor  Diagnosis/Cause  Treatment  Outcome    Medical death   Death      Cure Surgical cure  Chronic     Rehabilation   Group of Patients’ Trend  Community  -burden
Randomized controlled trial ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Randomized controlled trial ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],Randomized controlled trial New treatment   Current  treatment/ no treatment   Improved Not  improved   Improved  Not  improved Intervention Outcome Selection of subjects -similar features  -inclusion/exclusion criteria Allocation of   subjects Data collection Masking   (blinding) Define population
Type of randomized clinical trials Surgical Medical  randomized randomized Refuse surgery Require surgery No surgery Surgery ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Randomized controlled trial ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Randomized controlled trial ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Randomized controlled trial ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Observational studies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cohort study Exposed  Disease  Future  Now  Not  Exposed  No Disease  Disease  No Disease  Association Historical data Concurrent  data 1970 2005 2010 2005 2010
When is a cohort study warranted ? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cohort study Disease (+) Exposed (+) Exposed (-) Disease (-) Total Incidence rate of disease a b c d a + b c + d a/a+b c/c+d
Case control study Exposed  Disease In the past  Now  No disease  Not  Exposed  Exposed  Not  Exposed  Case Control Non-randomized
Case control study ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
When is a case control warranted? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Case control study Disease (+) Exposed (+) Exposed (-) Disease (-) Total a b c d a + b c + d Odd ratio  =  a/a+c  =  ad b/b+d  bc Proportion of exposed   a a+c b b+d
Cross sectional study ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ecologic or trend study ,[object Object],[object Object],[object Object]
Case report or case studies ,[object Object],[object Object],[object Object],[object Object]
Qualitative study ,[object Object],[object Object],[object Object],[object Object],[object Object]
Summary Design depends on research Q Treatment efficacy/safety – RCT Diagnostic methods – x section Prognosis- outcome - cohort Agreement measurement –  X sectional Classification - cohort (outcome), X section (criteria)

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Study Designs_YL

  • 1. Study Design Yvonne Lee Yin Leng, MPH Clinical Epidemiology Unit, CRC
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  • 15. Cohort study Exposed Disease Future Now Not Exposed No Disease Disease No Disease Association Historical data Concurrent data 1970 2005 2010 2005 2010
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  • 17. Cohort study Disease (+) Exposed (+) Exposed (-) Disease (-) Total Incidence rate of disease a b c d a + b c + d a/a+b c/c+d
  • 18. Case control study Exposed Disease In the past Now No disease Not Exposed Exposed Not Exposed Case Control Non-randomized
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  • 20.
  • 21. Case control study Disease (+) Exposed (+) Exposed (-) Disease (-) Total a b c d a + b c + d Odd ratio = a/a+c = ad b/b+d bc Proportion of exposed a a+c b b+d
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  • 26. Summary Design depends on research Q Treatment efficacy/safety – RCT Diagnostic methods – x section Prognosis- outcome - cohort Agreement measurement – X sectional Classification - cohort (outcome), X section (criteria)

Notes de l'éditeur

  1. Question – what r the study designs you know of?
  2. Research question will be followed desc by my colleague
  3. For this session we will discuss some of the most commonly used study designs
  4. More than 2 contacts regular interval but can vary from weeks, months, year Longer period Info gathered each time is identical Data from Same study population but NOT necessary same respondent