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October 25, 2009 Chronic Myeloid Leukemia(CML)
What is CML ? Chronic myeloid leukemia is a cancer of the blood system in which too many white blood cells (WBCs) are made in the bone marrow.
Molecular Basis  This exchange brings together two genes:  The BCR  gene on chromosome 22 and the proto-oncogene ABL on chromosome 9.  ,[object Object]
The Ph chromosome is the result of a translocation between the long arms of chromosomes 9 and 22. ,[object Object]
CML dIAGnoSIS Blood Test Blood cell counts. With CML, the red cell count is lower than normal. The number of white cells is higher than normal and may be very high.  Blood cell examination. A person with CML has a small number of developing cells called "blast cells" in his or her blood. Blast cells are not found in the blood of healthy individuals.  Bone Marrow Test Samples of marrow cells are examined under a microscope. This is called a cytogenetic analysis. The examiner looks at a map of the chromosomes in the cell. The map is called a "karyotype." The Ph chromosome in a CML cell can be detected on the karyotype.
Phases of CML
TREATMENTS Chemotherapy ,[object Object]
Removal of the spleen
 The newest treatment is Gleevec®, a therapy that is believed to interfere with the action of the abnormalities in CML white blood cells.,[object Object]
Survival Rates by Treatment

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Chronic Myeloid Leukemia

  • 1. October 25, 2009 Chronic Myeloid Leukemia(CML)
  • 2. What is CML ? Chronic myeloid leukemia is a cancer of the blood system in which too many white blood cells (WBCs) are made in the bone marrow.
  • 3.
  • 4.
  • 5. CML dIAGnoSIS Blood Test Blood cell counts. With CML, the red cell count is lower than normal. The number of white cells is higher than normal and may be very high. Blood cell examination. A person with CML has a small number of developing cells called "blast cells" in his or her blood. Blast cells are not found in the blood of healthy individuals. Bone Marrow Test Samples of marrow cells are examined under a microscope. This is called a cytogenetic analysis. The examiner looks at a map of the chromosomes in the cell. The map is called a "karyotype." The Ph chromosome in a CML cell can be detected on the karyotype.
  • 7.
  • 9.
  • 10. Survival Rates by Treatment
  • 11.