1. Healthy Heart – An Ayurvedic
Approach
Under the Guidance of, By,
Dr.Ashalatha.M. Dr.Tanmaya.K.Acharya
H.O.D., Dept of P.G.Studies in
Dravyaguna, II M.D., Dept of Dravyaguna
G.A.M.C., Bengaluru G.A.M.C., Bengaluru

2. Introduction
• India has the largest Cardio-vascular
Disease rate in the world.
• Ganas mentioned specifically in Charaka
and Sushrutha Samhita for Hrdya karma
and Hrd roga
• Hrdya gana, Parushakadi gana,
Bruhatyadi gana, Utpaladi gana, Balya
dashemani, Lekhaneeya dashemani.

3. • Charaka Hrdya Gana:
Amra Amrataka
Likucha Karamarda
Vrkshamla Amlavetasa
Kuvala Badara
Dadima Matulunga
• Sushruta Vargas:
• Bruhatyadi :
Bruhati Kantakari
Kutajaphala Patha
Madhuka

4. • Parushakadi varga:
Parushaka Draksha
Katphala Dadima
Rajadana Katakaphala
Sakaphala Triphala
• Utpaladi varga:
Utpala Raktotpala
Kumuda Saugandhika
Kuvalaya Pundarika
Madhuka

5. Amra :Mangifera indica
Phytoconstituents Activity
Mangiferin : Poly Alteration of Cardiac
phenol mitochondrial energy
metabolism

6. Karamarda :Carrisa carandas
Phytoconstituents Activity
Triterpene: Carissol Ia Cardio tonic activity
Carissic Ib

7. Bruhati :Solanum indicum
Phytoconstituents Activity
Chlorogenic acid Blood pressure
lowering effects

8. Madhuka :Madhuca indica
Phytoconstituents Activity
Madhucosides A & B Significant inhibitory
Protobassic acid effects superoxide
release from
polymorphonuclear
cells.

9. Draksha :Vitis vinifera
Phytoconstituents Activity
Procyanidins Supplementation
makes the heart less
susceptible to
ischemia/reperfusion
damage.

10. Kamala :Nelumbo nucifera
Phytoconstituents Activity
Daurisoline Antiarrhythmic effect
Neferine Hypotensive effect

11. Brahmi :Bacopa monnieri
Phytoconstituents Activity
Sterol glycoside : Antihypertensives
Bacosterol-3-0-beta-D- Vasodilators
glucopyroside
Bacopa saponnin-C,
Bacopaside-1, Bacopaside
II

12. Chitraka :Plumbago zeylanica
Phytoconstituents Activity
Plumbagin Regression of
Atheroma
Reduces serum
cholesterol, LDL
cholesterol

13. Arka :Calatropis procera
Phytoconstituents Activity
Calotropagenin Inhibitors of Na(+) /K(+) -
ATPase to regulate heart
contractions

14. Conclusion
• Various approach towards
cardio-protective activity:
• Protective: Amra, Madhuka,
Draksha
• Anti-hypertensives: Bruhati, Brahmi
• Inotropic activity : Karamarda
• Chronotropic activity : Kamala, Arka
• Anti-cholesterol : Chitraka
• The need to fill the lacuna between
Literature Research Implementation
• Rediscover the connection between ‘Plant’ and ‘Health’

15. References
• Effect of mangiferin on mitochondrial energy production in experimentally induced myocardial
infarcted rats.
Department of Biochemistry, University of Madras, A.C. Tech., Guindy campus, Chennai-600 025, India.
• BIOSYNTHESIS OF CAR1SSOL AND CARISSIC ACID.
Department of Chemistry, University of Karachi, Karachi-75270, Pakistan.
• Solanum indicum ssp. distichum extract is effective against L-NAME-induced hypertension in rats.
Department of Pharmacology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
• Madhucosides A and B, protobassic acid glycosides from Madhuca indica with inhibitory activity on
free radical release from phagocytes.
Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67,
SAS Nagar, Punjab 160062, India.
• Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-
ischaemic damage in rats.
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Italy.
• Effects of neferine on transmembrane potentials of guinea pig myocardium.
Li GR, Li XG, Lü FH
• Bacopa monnieri and its constituents is hypotensive in anaesthetized rats and vasodilator in various
artery types.
Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000,
Thailand.
• Hypolipidaemic and antiatherosclerotic effects of plumbagin in rabbits.
Department of Zoology, University of Rajasthan, Jaipur.
• Rapid identification of calotropagenin glycosides using high-performance liquid chromatography
electrospray ionisation tandem mass spectrometry.
Sophisticated Analytical Instrument Facility, Central Drug Research Institute, Lucknow, 226001,