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Life	
  Science	
  Venture	
  Fast	
  Track	
  
Pitching	
  the	
  Plan:	
  The	
  Deck
Jeremy	
  Halpern	
  
Partner,	
  Nutter	
  McClennen	
  &	
  Fish;	
  	
  
Director,	
  MassVentures	
  
David	
  Greenwald,	
  Ph.D.	
  
Founder,	
  Relay	
  Technology	
  Management	
  

Seaport	
  West,	
  155	
  Seaport	
  Boulevard,	
  Boston	
  MA	
  02210	
  	
  www.nutter.com	
  
Jeremy	
  Halpern	
  
Biography	
  

›  Nutter,	
  McClennen	
  &	
  Fish,	
  LLP	
  -­‐	
  Partner;	
  Director	
  of	
  Biz	
  Dev,	
  ECG	
  
•  Top	
  10	
  Boston	
  law	
  firm	
  
•  Represent	
  clients	
  in	
  technology,	
  hardware,	
  software,	
  mobile,	
  	
  medtech	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  health	
  
IT,	
  biotechnology,	
  cleantech	
  CPG,	
  consumer	
  electronics	
  

›  MassVentures	
  –	
  Director	
  &	
  Investment	
  Committee	
  Member	
  
•  The	
  Venture	
  Arm	
  of	
  the	
  Commonwealth:	
  providing	
  seed	
  and	
  early	
  stage	
  venture	
  funding	
  
to	
  high	
  growth	
  technology	
  startups	
  

›  Angel	
  Investor	
  –	
  Private	
  investor	
  in	
  multiple	
  technology	
  and	
  consumer	
  products	
  companies	
  
›  The	
  Capital	
  Network	
  –	
  Director;	
  Past	
  Executive	
  Chairman	
  
•  Providing	
  education,	
  resources	
  and	
  community	
  to	
  high	
  growth	
  entrepreneurs	
  and	
  angel	
  
investors	
  as	
  they	
  navigate	
  the	
  early	
  stage	
  capital	
  process	
  

›  Previously:	
  Co-­‐Founder/VP	
  Biz	
  Dev	
  MobileTek	
  Corporation	
  
›  UC	
  Berkeley,	
  B.A.	
  (Go	
  Bears!);	
  UCLA	
  School	
  of	
  Law,	
  J.D.;	
  Admitted	
  to	
  practice,	
  CA	
  and	
  MA	
  

2
David	
  Greenwald,	
  Ph.D.	
  
Biography	
  

›  Director	
  of	
  Client	
  Solutions	
  at	
  Decision	
  Resources	
  
›  Founder,	
  Relay	
  Technology	
  Management	
  (acquired	
  by	
  Decision	
  Resources	
  2013)	
  
›  Enabling	
  data-­‐driven	
  decision-­‐making	
  via	
  objective,	
  real-­‐time	
  business	
  intelligence	
  and	
  
trend	
  analytics	
  for	
  the	
  life	
  science	
  industry	
  leading	
  to	
  increased	
  efficiency	
  in	
  drug	
  
development.	
  	
  

›  Mass	
  Challenge	
  Finalist	
  2010	
  
›  Johns	
  Hopkins	
  Carey	
  Business	
  School	
  
›  Lecturer,	
  Entrepreneurial	
  Finance	
  
›  Tufts	
  Gordon	
  Institute	
  
›  Lecturer,	
  High	
  Technology	
  Entrepreneurship	
  &	
  Business	
  Planning	
  
›  University	
  of	
  Maryland	
  College	
  Park,	
  B.S.,	
  Cellular	
  Molecular	
  Biology	
  &	
  Genetics	
  
›  Tufts	
  University,	
  Ph.D.,	
  Genetics	
  

3
Cover	
  Slide	
  Introduction	
  
•  1	
  Minute	
  Elevator	
  Pitch	
  
–  Get	
  their	
  attention!	
  	
  
•  Introduce	
  company	
  without	
  distracting	
  from	
  spoken	
  introduction	
  
•  Sets	
  the	
  tempo	
  
•  Content:	
  
–  Logo	
  	
  
–  Tag	
  Line	
  –	
  should	
  explain	
  business	
  and	
  begin	
  to	
  differentiate	
  
–  Contact	
  information	
  
‒  Name	
  of	
  the	
  investor/group	
  to	
  whom	
  presentation	
  is	
  delivered	
  
‒  Possibly	
  a	
  non-­‐distracting	
  picture	
   	
  	
  
•  Be	
  enthusiastic	
  –	
  people	
  buy	
  from	
  people	
  not	
  PowerPoint	
  

4
Problem	
  
•  What	
  is	
  the	
  unsolved	
  problem	
  or	
  need?	
  	
  	
  
•  Who	
  has	
  this	
  problem?	
  	
  Define	
  your	
  Core	
  Customer	
  and	
  their	
  attributes	
  
•  How	
  serious	
  is	
  it?	
  Do	
  you	
  have	
  Metrics?	
  	
  	
  
–  Magnitude	
  :	
  How	
  significant	
  is	
  it?	
  	
  Can	
  you	
  quantify	
  it?	
  
–  Frequency:	
  	
  How	
  often	
  is	
  pain	
  experienced	
  (life	
  insurance	
  vs.	
  coffee)	
  
–  Criticality:	
  	
  Will	
  the	
  pain	
  disrupt	
  the	
  business	
  (e.g.,	
  IT	
  outage)	
  

Cancer	
  Drug	
  vs.	
  Aspirin	
  vs.	
  Vitamin?	
  	
  
•  How	
  have	
  the	
  alternative	
  offerings	
  failed	
  to	
  meet	
  the	
  need?	
  
•  Analysis	
  of	
  why	
  has	
  the	
  problem	
  not	
  been	
  solved	
  until	
  now?	
  
•  Remember!	
  
–  Customers	
  buy	
  if	
  they	
  experience	
  need,	
  not	
  if	
  society	
  does.	
  
–  Business	
  customer	
  buy	
  to	
  make	
  money	
  or	
  solve	
  problems.	
  
5
Solution	
  
•  Describe	
  your	
  product	
  or	
  service?	
  	
  	
  
•  What	
  does	
  it	
  do	
  and	
  how	
  does	
  it	
  work?	
  
•  Do	
  not	
  get	
  too	
  detailed?	
  	
  Assume	
  technical	
  matters	
  will	
  be	
  validated	
  later.	
  
•  Use	
  pictures	
  or	
  diagrams	
  where	
  possible.	
  	
  	
  
•  Demo	
  /	
  screen	
  shots,	
  etc.	
  if	
  necessary.	
  
•  How	
  does	
  it	
  fit	
  within	
  the	
  customer's	
  environment?	
  
•  What	
  proof	
  of	
  concept	
  have	
  you	
  achieved?	
  Prototype?	
  	
  Beta?	
  	
  
•  Small	
  /	
  Large	
  Animals,	
  En	
  Vitro,	
  En	
  Vivo	
  

•  What	
  proof	
  do	
  you	
  have	
  of	
  its	
  effectiveness?	
  
•  Use	
  accurate	
  words	
  to	
  describe	
  phase	
  of	
  development:	
  	
  
•  “it	
  does”	
  vs.	
  “it	
  will”	
  vs.	
  “it	
  may”	
  
6
Regulatory	
  Path	
  and	
  Progress	
  
•  Are	
  you	
  IND	
  or	
  510k?	
  	
  Any	
  additional	
  details?	
  
•  Costs	
  and	
  timing	
  and	
  patient	
  population	
  of	
  trials	
  needed	
  to	
  obtain	
  approval?	
  
•  Phase	
  1,	
  Phase	
  2	
  (2b),	
  Phase	
  III	
  

•  Strategy?	
  
•  	
  Team	
  or	
  consultants	
  with	
  experience	
  in	
  obtaining	
  approval?	
  
•  Roadblocks	
  or	
  risks?	
  
•  Relationship	
  of	
  path	
  to	
  exit	
  timing	
  

7
Competitive	
  Advantage	
  
•  How	
  is	
  your	
  solution	
  better,	
  faster	
  or	
  cheaper	
  than	
  the	
  existing	
  solutions	
  
for	
  your	
  customer?	
  	
  **Remember	
  Different	
  ≠	
  Better**	
  
–  Saves	
  costs	
  -­‐	
  
–  Drives	
  revenue	
  or	
  customer	
  acquisition	
  
–  Allows	
  customer	
  to	
  offer	
  its	
  customers	
  a	
  superior	
  value	
  proposition	
  	
  
–  Decreases	
  risks	
  
–  Leverages	
  customer's	
  existing	
  customers	
  or	
  solutions	
  
–  Provides	
  enjoyment,	
  recreation,	
  education,	
  time	
  saving…	
  (consumer	
  
product)	
  
•  How	
  much	
  better,	
  faster,	
  cheaper?	
  Can	
  you	
  quantify	
  the	
  value	
  proposition	
  
to	
  the	
  customer?	
  	
  
–  Can	
  you	
  validate	
  that	
  your	
  solution	
  is	
  better?	
  	
  Do	
  you	
  have	
  data	
  to	
  
indicate	
  that	
  such	
  items	
  are	
  meaningful	
  to	
  the	
  customer?	
  	
  
–  Can	
  you	
  quantify	
  a	
  Return	
  on	
  Investment	
  (ROI)	
  for	
  your	
  customer.	
  	
  
8
Competitive	
  Landscape	
  
•  Who	
  is	
  competing	
  with	
  you?	
  	
  
•  Barriers	
  	
  to	
  entry	
  for	
  you?	
  For	
  others?	
  	
  Ones	
  that	
  you	
  are	
  creating?	
  	
  
•  Blocking	
  IP	
  

•  Geography	
  

•  Startup	
  	
  Cost	
  to	
  competition	
  	
  

•  Contract	
  exclusivity	
  or	
  change	
  penalties	
  

•  Change	
  Cost	
  to	
  customers	
  

•  Market	
  dominating	
  companies	
  (“800lb	
  Gorillas”)	
  

•  Competitive Advantage revisited - Why will you be able to win (not “cooler”)
•  Points solution vs. total solutions
•  Current major competitors and why you will beat them
•  Avoiding the “no-competition trap”
•  Explaining their trends of growth or contraction
•  On a matrix – show advantages and areas where you don't compete
•  Pick metrics your customers care about not just those you “win” at!
•  Avoid upper right quadrant graphs

9
Comparative	
  Effectiveness	
  &	
  Focus	
  
•  Choose criteria important to your customers and end users / patients
•  Show focus: being best in class in only certain things
•  Show where you are not competing
Criteria	
  1	
  

Criteria	
  2	
  

Criteria	
  3	
  

Criteria	
  4	
  

You	
  
Competitor	
  1	
  
Competitor	
  2	
  
Competitor	
  3	
  

10
Business	
  and	
  Revenue	
  Model	
  
•  How	
  and	
  when	
  will	
  you	
  make	
  money?	
  
•  Who	
  is	
  going	
  to	
  pay	
  (i.e,	
  what	
  is	
  the	
  “Revenue	
  Model”)?	
  	
  Explain	
  are	
  YOUR	
  customers?	
  
•  Manufacturing	
  and	
  commercialization	
  strategies	
  
•  Timing	
  and	
  frequency	
  of	
  buying	
  decision	
  and	
  payments	
  
•  Average	
  $/purchase?	
  	
  	
  Likely	
  to	
  increase	
  or	
  decrease?	
  
•  Fixed	
  vs.	
  variable	
  costs	
  
•  Revenue	
  Model	
  –	
  and	
  consequences	
  to	
  volume,	
  price,	
  margin	
  etc.	
  of	
  each:	
  
•  Direct	
  Sales	
  
•  Indirect	
  Sales	
  
•  Razor	
  and	
  Blade	
  
•  Professional	
  Services	
  
•  SAAS	
  
•  Licensing	
  
•  Government	
  Contractor	
  

11
Sales	
  and	
  Distribution	
  Model	
  
How	
  you	
  get	
  your	
  customers	
  and	
  costs	
  	
  
How	
  you	
  actually	
  deliver	
  solution	
  to	
  customers	
  (trucks,	
  distributors	
  or	
  click?)	
  
Go-­‐to-­‐Market	
  and	
  General	
  Marketing	
  strategies	
  
How	
  you	
  incentivize	
  and	
  compensate	
  sales	
  (if	
  applicable)	
  
Explain	
  geography	
  and	
  expansion	
  strategy	
  (scaling	
  or	
  growth	
  issues)	
  
Discuss	
  critical	
  distribution	
  partners,	
  options	
  and	
  roadblocks	
  
Core	
  business	
  vs.	
  non-­‐core	
  business	
  	
  
•  potential	
  licensing	
  or	
  spin-­‐off	
  opportunity	
  
•  Conversion	
  metrics	
  (identification	
  >	
  lead	
  >	
  sales	
  process	
  >	
  conversion)	
  
• 
• 
• 
• 
• 
• 
• 

12
Cost	
  vs.	
  Revenue	
  /	
  Role	
  of	
  Reimbursement	
  
•  You	
  cannot	
  “help	
  the	
  system	
  save	
  money”	
  	
  
–  if	
  your	
  solution	
  is	
  cheaper	
  than	
  	
  the	
  competition,	
  understanding	
  the	
  motivation	
  of	
  
the	
  payor	
  vs	
  the	
  provider	
  (to	
  whom	
  cost	
  may	
  equal	
  revenue)	
  

•  Who	
  saves?	
  Who's	
  business	
  does	
  this	
  hurt?	
  
•  Will	
  you	
  need	
  reimbursement?	
  
–  Status	
  of	
  code	
  designation?	
  Strategy?	
  

•  Comparables	
  for	
  reimbursement	
  pricing?	
  
•  If	
  deployed	
  onto	
  patients,	
  the	
  long	
  term	
  savings	
  to	
  payor?	
  

13
Addressable	
  Market	
  /	
  Segmentation	
  Analysis	
  
•  Industry	
  size	
  =	
  the	
  total	
  revenue	
  generated	
  in	
  a	
  segment	
  of	
  the	
  economy.	
  	
  
•  These	
  are	
  what	
  are	
  tracked	
  by	
  Forrester,	
  Gartner,	
  Thomson	
  etc.	
  
•  Only	
  useful	
  for	
  trend	
  analysis,	
  not	
  for	
  evaluating	
  investability.	
  	
  
•  Example:	
  “The	
  internet	
  advertising	
  industry	
  is	
  an	
  $X	
  billion	
  industry”	
  
•  Addressable	
  Market	
  =	
  the	
  total	
  amount	
  of	
  revenue	
  that	
  your	
  company	
  could	
  generate	
  
if	
  it	
  acquired	
  every	
  potential	
  customer	
  (the	
  “Addressable	
  Population”).	
  
•  Willing	
  and	
  able	
  buyers	
  that	
  you	
  can	
  reach	
  
•  Initial	
  Target	
  Market:	
  	
  subset	
  of	
  the	
  addressable	
  market	
  for	
  whom	
  the	
  value	
  
proposition	
  is	
  truly	
  compelling	
  and	
  obvious	
  at	
  product	
  introduction.	
  
•  Annual	
  Sales:	
  	
  that	
  subset	
  of	
  the	
  addressable	
  market	
  or	
  the	
  initial	
  target	
  market	
  
who	
  buy	
  or	
  who	
  are	
  likely	
  to	
  buy	
  each	
  year.	
  
•  Explain	
  how	
  the	
  market	
  is	
  changing	
  and	
  why.	
  	
  	
  
•  Customers,	
  pricing,	
  competition,	
  new	
  technology,	
  etc.	
  	
  
•  $500m	
  TAM	
  vs.	
  $50m	
  TAM	
  –	
  know	
  your	
  investors!	
  

14
Defensibility	
  
•  Intellectual	
  Property:	
  Patents,	
  Trademarks,	
  Copyrights,	
  Trade	
  Secret	
  
•  Difference	
  between	
  provisional,	
  applications	
  and	
  granted	
  patents	
  
•  Patent	
  strategy	
  
•  IP	
  that	
  covers	
  advantage	
  vs.	
  extraneous	
  claims/assets	
  
•  How	
  unique	
  is	
  your	
  solution?	
  
•  Trade	
  Secret	
  and	
  development	
  lead;	
  Ease	
  of	
  replication	
  
•  Cost/Ability	
  of	
  customer	
  to	
  replace	
  your	
  Solution	
  
•  Key	
  relationships	
  	
  
•  Contractual	
  protection	
  
•  FDA	
  approval	
  designations	
  

15
Management	
  Team	
  and	
  Advisors	
  
•  Top	
  executives,	
  Board	
  of	
  Directors,	
  Board	
  of	
  Advisors	
  &	
  SAB	
  
•  Startup,	
  domain,	
  customers	
  or	
  key	
  opinion	
  experience	
  
•  Prior	
  success	
  
•  Balance	
  
•  Cohesiveness	
  
•  Don't	
  put	
  their	
  whole	
  resume	
  on	
  the	
  slide	
  
•  Only	
  show	
  actives	
  
•  Current	
  staffing	
  gaps	
  and	
  strategy	
  for	
  filling	
  
•  Orientation	
  towards	
  success	
  not	
  control	
  (“Rich”	
  not	
  “Monarch”)	
  

16
Current	
  Status:	
  	
  	
  Achievements,	
  Upcoming	
  Milestones	
  
•  Demonstrate	
  current	
  progress	
  and	
  achievement	
  of	
  milestones	
  
•  Development	
  partnerships	
  
•  Distribution	
  partnerships	
  
•  Customer	
  acquisition	
  progress	
  (conversion	
  rates)	
  
•  Publications	
  
•  Financing	
  
•  Team	
  Developments	
  
•  Upcoming	
  milestones	
  and	
  Challenges	
  	
  
•  Gant-­‐style	
  Charts	
  
•  How	
  you	
  will	
  overcome	
  the	
  challenges/weakness	
  	
  (ex.	
  key	
  hire)	
  
•  Often	
  integrated	
  with	
  use	
  of	
  proceeds	
  slide	
  

17
Funding,	
  Cash	
  and	
  Use	
  of	
  Proceeds	
  
•  Identify	
  existing/timing	
  of	
  prior	
  preferred	
  stock	
  deals	
  
•  Cash	
  and	
  monthly	
  cash	
  burn	
  
•  How	
  much	
  of	
  burn	
  is	
  variable	
  vs.	
  fixed	
  	
  
•  Lowest	
  you	
  can	
  the	
  Burn	
  without	
  killing	
  the	
  company	
  
•  Time	
  and	
  investment	
  dollars	
  to	
  reach	
  exit	
  
•  Timing	
  and	
  quantity	
  of	
  future	
  rounds	
  
•  Current	
  round	
  size	
  and	
  timing	
  
•  Use	
  of	
  proceeds	
  -­‐	
  what	
  will	
  it	
  be	
  used	
  for?	
  What	
  will	
  it	
  buy?	
  	
  
•  Optimal	
  deal	
  structure	
  
•  Pre	
  Money	
  Valuation	
  
•  Dangers	
  of	
  including	
  suggested	
  valuations	
  
•  Dangers	
  of	
  not	
  knowing	
  the	
  appropriate	
  valuations	
  

18
Risks	
  and	
  Plans	
  
•  Technology	
  	
  /	
  Product	
  –	
  Will	
  the	
  solution	
  work?	
  	
  Can	
  you	
  build	
  it?	
  	
  
•  Business	
  Model	
  –	
  Can	
  you	
  sell	
  the	
  solution	
  at	
  margin?	
  
•  Supply	
  –	
  Can	
  you	
  acquire	
  and	
  manage	
  critical	
  vendors	
  
•  Customer	
  Adoption	
  Risk	
  –	
  Will	
  the	
  Dogs	
  eat	
  the	
  Dog	
  Food?	
  
•  Market	
  Dynamics	
  –	
  Do	
  customers	
  have	
  cash	
  and	
  the	
  will	
  to	
  spend?	
  
•  Distribution	
  Risk	
  -­‐	
  Can	
  you	
  acquire	
  and	
  run	
  critical	
  distribution	
  and	
  sales	
  points?	
  
•  Competition	
  Risk	
  –	
  Is	
  there	
  an	
  opportunity	
  in	
  the	
  marketplace?	
  Will	
  an	
  800lb	
  gorilla	
  eat	
  
your	
  lunch?	
  
•  Financial	
  risks	
  –Will	
  you	
  have	
  sufficient	
  capital	
  now	
  and	
  in	
  the	
  future?	
  
•  Legal	
  risks	
  –Freedom	
  to	
  operate	
  ?	
  Do	
  you	
  have	
  the	
  ability	
  to	
  defend	
  your	
  IP?	
  
•  Regulatory	
  risks	
  –	
  Are	
  there	
  barriers	
  beyond	
  your	
  ability	
  to	
  influence?	
  FDA?	
  	
  
•  Team	
  risks	
  –	
  Is	
  our	
  product	
  or	
  customer	
  knowledge	
  distributed	
  and	
  accessible?	
  	
  
•  Exit	
  Risk	
  –	
  Are	
  there	
  willing	
  buyers	
  (or	
  a	
  public	
  market)	
  for	
  your	
  company?	
  

19
Exit	
  Strategy	
  and	
  Options	
  
•  Length	
  to	
  liquidity	
  
•  IPO	
  vs.	
  M&A	
  vs.	
  Licensing	
  (vs.	
  other)	
  
•  Potential	
  Acquirers	
  
•  Acquirer	
  characteristics	
  and	
  rationale	
  for	
  acquisition	
  
•  How	
  frothy	
  is	
  the	
  current/expected	
  market	
  now	
  and	
  at	
  maturity	
  
•  Recent	
  exits	
  for	
  similarly	
  situated	
  companies	
  
•  Valuations	
  (if	
  available)	
  
•  Counterpoint:	
  Building	
  a	
  company	
  vs.	
  building	
  an	
  exit	
  

20
Summary	
  Slide	
  /	
  Investment	
  Rationale	
  
• 
• 
• 
• 

End	
  with	
  a	
  summary	
  of	
  what	
  you	
  have	
  just	
  said.	
  
Leave	
  them	
  with	
  the	
  key	
  message	
  points	
  you	
  are	
  trying	
  to	
  convey.	
  
Be	
  prepared	
  for	
  questions	
  
	
  Appendices	
  
•  All	
  of	
  the	
  information	
  that	
  may	
  backstop	
  your	
  conclusions	
  
•  Case	
  studies	
  
•  Customer	
  testimonials	
  
•  More	
  detailed	
  technical	
  or	
  product	
  information	
  
•  More	
  detailed	
  market	
  or	
  customer	
  information	
  	
  
•  Demo	
  videos	
  

21
Financials	
  and	
  Projections	
  
• 
• 
• 
• 

• 
• 
• 
• 
• 
• 
• 

P&L	
  –	
  Historical	
  +	
  3-­‐5yrs;	
  Often	
  with	
  cash,	
  customers	
  and	
  headcount	
  
Segment	
  revenue	
  by	
  type	
  of	
  revenue	
  
Fixed	
  vs.	
  Variable	
  cost	
  structure	
  
Revenue	
  and	
  Margin	
  Ratios	
  
•  Think	
  about	
  cash	
  flow	
  timing	
  issues	
  –	
  see	
  revenue	
  model	
  (e.g.,	
  direct/
reimbursement)	
  
Bottom-­‐Up	
  vs.	
  Top-­‐Down	
  projections	
  
Assumption	
  tab	
  in	
  the	
  Excel	
  build	
  
What	
  does	
  “conservative”	
  mean:	
  Use	
  of	
  High	
  /	
  Medium	
  /	
  Low	
  
Perfect	
  vs.	
  Functional	
  –	
  Running	
  your	
  business	
  vs.	
  Building	
  a	
  model	
  
Anticipating	
  investor	
  cutback	
  
Risks	
  of	
  projections	
  being	
  tied	
  to	
  equity	
  and	
  compensation	
  
Valuation	
  Issues	
  
22
General	
  Dos	
  and	
  Don'ts:	
  	
  

“Presentation	
  is	
  a	
  visual	
  not	
  a	
  reference”	
  

Do	
  
•  Use	
  one	
  topic	
  per	
  slide	
  

Don't	
  
•  Use	
  sounds	
  with	
  slide	
  transitions	
  

• 

Limit	
  text	
  on	
  each	
  slide	
  

• 

Overdo	
  the	
  ALL	
  CAPS,	
  bolded,	
  
italicized	
  or	
  underlined	
  text	
  

• 

Use	
  pictures,	
  graphs,	
  video's	
  
–  Not	
  all	
  bullets	
  

• 

Use	
  too	
  many	
  different	
  	
  fonts	
  

• 

Choose	
  fonts	
  and	
  colors	
  that	
  are	
  easy	
  
to	
  read	
  

• 

Overuse	
  special	
  effects	
  –	
  focus	
  on	
  the	
  
content	
  

• 

PowerPoint	
  is	
  the	
  accessory	
  to	
  YOUR	
  
presentation	
  

• 

Have	
  technical	
  difficulties	
  –	
  test	
  before	
  
the	
  meeting	
  

• 

Spell	
  Check	
  

23
Presentation	
  Skills:	
  Part	
  I	
  
• 

Know	
  your	
  material	
  cold!	
  	
  Don't	
  wing	
  it.	
  	
  

• 

DON'T	
  READ	
  your	
  presentation.	
  	
  	
  

• 

You	
  should	
  have	
  answers	
  to	
  likely	
  questions.	
  

• 

Be	
  clear	
  when	
  you	
  don't	
  know	
  an	
  answer	
  –	
  then	
  follow	
  up.	
  	
  

• 

When	
  possible,	
  know	
  the	
  room.	
  Arrive	
  early,	
  walk	
  around	
  the	
  speaking	
  area	
  and	
  
practice	
  using	
  the	
  microphone	
  and	
  any	
  visual	
  aids.	
  	
  

• 

Body	
  language	
  and	
  appearance	
  =	
  50%	
  of	
  the	
  pitch	
  

• 

Prioritize	
  and	
  eliminate	
  less	
  critical	
  points.	
  	
  	
  

• 

Be	
  flexible	
  –	
  be	
  prepared	
  to	
  be	
  interrupted.	
  	
  

• 

Understand	
  the	
  goal	
  of	
  your	
  presentation.	
  	
  	
  Is	
  it	
  to	
  inspire,	
  to	
  educate,	
  to	
  
connect,	
  to	
  get	
  attention,	
  to	
  get	
  a	
  second	
  more	
  personal	
  meeting?	
  	
  	
  

24
Presentation	
  Skills:	
  Part	
  II	
  
• 

Modulate	
  your	
  pace,	
  pitch,	
  volume,	
  tone	
  and	
  enthusiasm	
  –	
  like	
  when	
  you	
  are	
  
telling	
  a	
  story.	
  	
  This	
  helps	
  keep	
  the	
  audience	
  focused.	
  	
  	
  

• 

Use	
  humor,	
  personal	
  stories	
  and	
  conversational	
  language	
  where	
  possible.	
  Use	
  
easy	
  to	
  understand	
  analogies.	
  

• 

Practice.	
  Practice.	
  Practice!	
  	
  GO	
  SEE	
  OTHER	
  PRESENTATIONS!	
  

• 

Slides	
  should	
  HELP	
  the	
  oral	
  presentation,	
  not	
  BE	
  the	
  presentation.	
  	
  

• 

Bring	
  a	
  backup	
  copy	
  on	
  a	
  flash	
  drive	
  and	
  via	
  cloud	
  	
  

• 

Slides	
  should	
  be	
  professional	
  and	
  consistent	
  with	
  your	
  image.	
  	
  

• 

Spend	
  more	
  time	
  building	
  the	
  business	
  than	
  the	
  presentation	
  

• 

Leave	
  time	
  for	
  questions.	
  

• 

RELAX,	
  BREATHE	
  and	
  SLOW	
  DOWN	
  

25
Interacting	
  with	
  Investors	
  
Basic	
  Principles	
  -­‐	
  Overview	
  	
  
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

Research	
  the	
  investor	
  in	
  advance	
  
Pay	
  attention	
  to	
  what	
  you	
  say	
  during	
  the	
  presentation	
  banter	
  
Communicate	
  
Be	
  likeable	
  	
  
State	
  your	
  value	
  proposition	
  up	
  front	
  
Come	
  prepared	
  with	
  sufficient	
  data	
  (including	
  back	
  up	
  slides)	
  
Enjoy	
  yourself	
  and	
  let	
  it	
  show	
  
Keep	
  the	
  presentation	
  within	
  allotted	
  time	
  
Be	
  realistic	
  about	
  valuations	
  in	
  the	
  market	
  
Make	
  due	
  diligence	
  easy	
  
Realize	
  investors	
  are	
  thinking	
  about	
  exit	
  strategy	
  

26
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

Interacting	
  with	
  Investors	
  
	
   	
  Cautionary	
  Overview	
  –	
  Don't	
  do	
  the	
  following	
  

Bash	
  the	
  competition	
  
Hype	
  
Condescend	
  or	
  talk	
  down	
  
Be	
  arrogant	
  
Be	
  vague	
  about	
  your	
  technology	
  	
  
Underestimate	
  the	
  importance	
  of	
  the	
  core	
  science/development	
  
Deluge	
  investors	
  with	
  facts	
  
Act	
  desperate	
  for	
  funding	
  (even	
  if	
  you	
  are)	
  
Act	
  like	
  you	
  don't	
  need	
  money	
  
List	
  'the	
  company	
  is	
  undervalued'	
  as	
  a	
  reason	
  to	
  invest	
  
Overprice	
  your	
  rounds	
  so	
  you	
  can	
  keep	
  stepping	
  up	
  valuation	
  
Give	
  investors	
  a	
  reason	
  to	
  turn	
  you	
  down	
  

27
Life	
  Science	
  Venture	
  Fast	
  Track	
  
Pitching	
  the	
  Plan:	
  The	
  Deck
Jeremy	
  Halpern	
  
Partner,	
  Nutter	
  McClennen	
  &	
  Fish;	
  
Director,	
  MassVentures	
  
jhalpern@nutter.com	
  
@startupboston	
  
617.439.2943	
  

Dave	
  Greenwald,	
  Ph.D.	
  
Founder,	
  Relay	
  Technology	
  Management	
  

Seaport	
  West,	
  155	
  Seaport	
  Boulevard,	
  Boston	
  MA	
  02210	
  	
  www.nutter.com	
  

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Pitching the plan - TCN Fast Track

  • 1. Life  Science  Venture  Fast  Track   Pitching  the  Plan:  The  Deck Jeremy  Halpern   Partner,  Nutter  McClennen  &  Fish;     Director,  MassVentures   David  Greenwald,  Ph.D.   Founder,  Relay  Technology  Management   Seaport  West,  155  Seaport  Boulevard,  Boston  MA  02210    www.nutter.com  
  • 2. Jeremy  Halpern   Biography   ›  Nutter,  McClennen  &  Fish,  LLP  -­‐  Partner;  Director  of  Biz  Dev,  ECG   •  Top  10  Boston  law  firm   •  Represent  clients  in  technology,  hardware,  software,  mobile,    medtech                                                      health   IT,  biotechnology,  cleantech  CPG,  consumer  electronics   ›  MassVentures  –  Director  &  Investment  Committee  Member   •  The  Venture  Arm  of  the  Commonwealth:  providing  seed  and  early  stage  venture  funding   to  high  growth  technology  startups   ›  Angel  Investor  –  Private  investor  in  multiple  technology  and  consumer  products  companies   ›  The  Capital  Network  –  Director;  Past  Executive  Chairman   •  Providing  education,  resources  and  community  to  high  growth  entrepreneurs  and  angel   investors  as  they  navigate  the  early  stage  capital  process   ›  Previously:  Co-­‐Founder/VP  Biz  Dev  MobileTek  Corporation   ›  UC  Berkeley,  B.A.  (Go  Bears!);  UCLA  School  of  Law,  J.D.;  Admitted  to  practice,  CA  and  MA   2
  • 3. David  Greenwald,  Ph.D.   Biography   ›  Director  of  Client  Solutions  at  Decision  Resources   ›  Founder,  Relay  Technology  Management  (acquired  by  Decision  Resources  2013)   ›  Enabling  data-­‐driven  decision-­‐making  via  objective,  real-­‐time  business  intelligence  and   trend  analytics  for  the  life  science  industry  leading  to  increased  efficiency  in  drug   development.     ›  Mass  Challenge  Finalist  2010   ›  Johns  Hopkins  Carey  Business  School   ›  Lecturer,  Entrepreneurial  Finance   ›  Tufts  Gordon  Institute   ›  Lecturer,  High  Technology  Entrepreneurship  &  Business  Planning   ›  University  of  Maryland  College  Park,  B.S.,  Cellular  Molecular  Biology  &  Genetics   ›  Tufts  University,  Ph.D.,  Genetics   3
  • 4. Cover  Slide  Introduction   •  1  Minute  Elevator  Pitch   –  Get  their  attention!     •  Introduce  company  without  distracting  from  spoken  introduction   •  Sets  the  tempo   •  Content:   –  Logo     –  Tag  Line  –  should  explain  business  and  begin  to  differentiate   –  Contact  information   ‒  Name  of  the  investor/group  to  whom  presentation  is  delivered   ‒  Possibly  a  non-­‐distracting  picture       •  Be  enthusiastic  –  people  buy  from  people  not  PowerPoint   4
  • 5. Problem   •  What  is  the  unsolved  problem  or  need?       •  Who  has  this  problem?    Define  your  Core  Customer  and  their  attributes   •  How  serious  is  it?  Do  you  have  Metrics?       –  Magnitude  :  How  significant  is  it?    Can  you  quantify  it?   –  Frequency:    How  often  is  pain  experienced  (life  insurance  vs.  coffee)   –  Criticality:    Will  the  pain  disrupt  the  business  (e.g.,  IT  outage)   Cancer  Drug  vs.  Aspirin  vs.  Vitamin?     •  How  have  the  alternative  offerings  failed  to  meet  the  need?   •  Analysis  of  why  has  the  problem  not  been  solved  until  now?   •  Remember!   –  Customers  buy  if  they  experience  need,  not  if  society  does.   –  Business  customer  buy  to  make  money  or  solve  problems.   5
  • 6. Solution   •  Describe  your  product  or  service?       •  What  does  it  do  and  how  does  it  work?   •  Do  not  get  too  detailed?    Assume  technical  matters  will  be  validated  later.   •  Use  pictures  or  diagrams  where  possible.       •  Demo  /  screen  shots,  etc.  if  necessary.   •  How  does  it  fit  within  the  customer's  environment?   •  What  proof  of  concept  have  you  achieved?  Prototype?    Beta?     •  Small  /  Large  Animals,  En  Vitro,  En  Vivo   •  What  proof  do  you  have  of  its  effectiveness?   •  Use  accurate  words  to  describe  phase  of  development:     •  “it  does”  vs.  “it  will”  vs.  “it  may”   6
  • 7. Regulatory  Path  and  Progress   •  Are  you  IND  or  510k?    Any  additional  details?   •  Costs  and  timing  and  patient  population  of  trials  needed  to  obtain  approval?   •  Phase  1,  Phase  2  (2b),  Phase  III   •  Strategy?   •   Team  or  consultants  with  experience  in  obtaining  approval?   •  Roadblocks  or  risks?   •  Relationship  of  path  to  exit  timing   7
  • 8. Competitive  Advantage   •  How  is  your  solution  better,  faster  or  cheaper  than  the  existing  solutions   for  your  customer?    **Remember  Different  ≠  Better**   –  Saves  costs  -­‐   –  Drives  revenue  or  customer  acquisition   –  Allows  customer  to  offer  its  customers  a  superior  value  proposition     –  Decreases  risks   –  Leverages  customer's  existing  customers  or  solutions   –  Provides  enjoyment,  recreation,  education,  time  saving…  (consumer   product)   •  How  much  better,  faster,  cheaper?  Can  you  quantify  the  value  proposition   to  the  customer?     –  Can  you  validate  that  your  solution  is  better?    Do  you  have  data  to   indicate  that  such  items  are  meaningful  to  the  customer?     –  Can  you  quantify  a  Return  on  Investment  (ROI)  for  your  customer.     8
  • 9. Competitive  Landscape   •  Who  is  competing  with  you?     •  Barriers    to  entry  for  you?  For  others?    Ones  that  you  are  creating?     •  Blocking  IP   •  Geography   •  Startup    Cost  to  competition     •  Contract  exclusivity  or  change  penalties   •  Change  Cost  to  customers   •  Market  dominating  companies  (“800lb  Gorillas”)   •  Competitive Advantage revisited - Why will you be able to win (not “cooler”) •  Points solution vs. total solutions •  Current major competitors and why you will beat them •  Avoiding the “no-competition trap” •  Explaining their trends of growth or contraction •  On a matrix – show advantages and areas where you don't compete •  Pick metrics your customers care about not just those you “win” at! •  Avoid upper right quadrant graphs 9
  • 10. Comparative  Effectiveness  &  Focus   •  Choose criteria important to your customers and end users / patients •  Show focus: being best in class in only certain things •  Show where you are not competing Criteria  1   Criteria  2   Criteria  3   Criteria  4   You   Competitor  1   Competitor  2   Competitor  3   10
  • 11. Business  and  Revenue  Model   •  How  and  when  will  you  make  money?   •  Who  is  going  to  pay  (i.e,  what  is  the  “Revenue  Model”)?    Explain  are  YOUR  customers?   •  Manufacturing  and  commercialization  strategies   •  Timing  and  frequency  of  buying  decision  and  payments   •  Average  $/purchase?      Likely  to  increase  or  decrease?   •  Fixed  vs.  variable  costs   •  Revenue  Model  –  and  consequences  to  volume,  price,  margin  etc.  of  each:   •  Direct  Sales   •  Indirect  Sales   •  Razor  and  Blade   •  Professional  Services   •  SAAS   •  Licensing   •  Government  Contractor   11
  • 12. Sales  and  Distribution  Model   How  you  get  your  customers  and  costs     How  you  actually  deliver  solution  to  customers  (trucks,  distributors  or  click?)   Go-­‐to-­‐Market  and  General  Marketing  strategies   How  you  incentivize  and  compensate  sales  (if  applicable)   Explain  geography  and  expansion  strategy  (scaling  or  growth  issues)   Discuss  critical  distribution  partners,  options  and  roadblocks   Core  business  vs.  non-­‐core  business     •  potential  licensing  or  spin-­‐off  opportunity   •  Conversion  metrics  (identification  >  lead  >  sales  process  >  conversion)   •  •  •  •  •  •  •  12
  • 13. Cost  vs.  Revenue  /  Role  of  Reimbursement   •  You  cannot  “help  the  system  save  money”     –  if  your  solution  is  cheaper  than    the  competition,  understanding  the  motivation  of   the  payor  vs  the  provider  (to  whom  cost  may  equal  revenue)   •  Who  saves?  Who's  business  does  this  hurt?   •  Will  you  need  reimbursement?   –  Status  of  code  designation?  Strategy?   •  Comparables  for  reimbursement  pricing?   •  If  deployed  onto  patients,  the  long  term  savings  to  payor?   13
  • 14. Addressable  Market  /  Segmentation  Analysis   •  Industry  size  =  the  total  revenue  generated  in  a  segment  of  the  economy.     •  These  are  what  are  tracked  by  Forrester,  Gartner,  Thomson  etc.   •  Only  useful  for  trend  analysis,  not  for  evaluating  investability.     •  Example:  “The  internet  advertising  industry  is  an  $X  billion  industry”   •  Addressable  Market  =  the  total  amount  of  revenue  that  your  company  could  generate   if  it  acquired  every  potential  customer  (the  “Addressable  Population”).   •  Willing  and  able  buyers  that  you  can  reach   •  Initial  Target  Market:    subset  of  the  addressable  market  for  whom  the  value   proposition  is  truly  compelling  and  obvious  at  product  introduction.   •  Annual  Sales:    that  subset  of  the  addressable  market  or  the  initial  target  market   who  buy  or  who  are  likely  to  buy  each  year.   •  Explain  how  the  market  is  changing  and  why.       •  Customers,  pricing,  competition,  new  technology,  etc.     •  $500m  TAM  vs.  $50m  TAM  –  know  your  investors!   14
  • 15. Defensibility   •  Intellectual  Property:  Patents,  Trademarks,  Copyrights,  Trade  Secret   •  Difference  between  provisional,  applications  and  granted  patents   •  Patent  strategy   •  IP  that  covers  advantage  vs.  extraneous  claims/assets   •  How  unique  is  your  solution?   •  Trade  Secret  and  development  lead;  Ease  of  replication   •  Cost/Ability  of  customer  to  replace  your  Solution   •  Key  relationships     •  Contractual  protection   •  FDA  approval  designations   15
  • 16. Management  Team  and  Advisors   •  Top  executives,  Board  of  Directors,  Board  of  Advisors  &  SAB   •  Startup,  domain,  customers  or  key  opinion  experience   •  Prior  success   •  Balance   •  Cohesiveness   •  Don't  put  their  whole  resume  on  the  slide   •  Only  show  actives   •  Current  staffing  gaps  and  strategy  for  filling   •  Orientation  towards  success  not  control  (“Rich”  not  “Monarch”)   16
  • 17. Current  Status:      Achievements,  Upcoming  Milestones   •  Demonstrate  current  progress  and  achievement  of  milestones   •  Development  partnerships   •  Distribution  partnerships   •  Customer  acquisition  progress  (conversion  rates)   •  Publications   •  Financing   •  Team  Developments   •  Upcoming  milestones  and  Challenges     •  Gant-­‐style  Charts   •  How  you  will  overcome  the  challenges/weakness    (ex.  key  hire)   •  Often  integrated  with  use  of  proceeds  slide   17
  • 18. Funding,  Cash  and  Use  of  Proceeds   •  Identify  existing/timing  of  prior  preferred  stock  deals   •  Cash  and  monthly  cash  burn   •  How  much  of  burn  is  variable  vs.  fixed     •  Lowest  you  can  the  Burn  without  killing  the  company   •  Time  and  investment  dollars  to  reach  exit   •  Timing  and  quantity  of  future  rounds   •  Current  round  size  and  timing   •  Use  of  proceeds  -­‐  what  will  it  be  used  for?  What  will  it  buy?     •  Optimal  deal  structure   •  Pre  Money  Valuation   •  Dangers  of  including  suggested  valuations   •  Dangers  of  not  knowing  the  appropriate  valuations   18
  • 19. Risks  and  Plans   •  Technology    /  Product  –  Will  the  solution  work?    Can  you  build  it?     •  Business  Model  –  Can  you  sell  the  solution  at  margin?   •  Supply  –  Can  you  acquire  and  manage  critical  vendors   •  Customer  Adoption  Risk  –  Will  the  Dogs  eat  the  Dog  Food?   •  Market  Dynamics  –  Do  customers  have  cash  and  the  will  to  spend?   •  Distribution  Risk  -­‐  Can  you  acquire  and  run  critical  distribution  and  sales  points?   •  Competition  Risk  –  Is  there  an  opportunity  in  the  marketplace?  Will  an  800lb  gorilla  eat   your  lunch?   •  Financial  risks  –Will  you  have  sufficient  capital  now  and  in  the  future?   •  Legal  risks  –Freedom  to  operate  ?  Do  you  have  the  ability  to  defend  your  IP?   •  Regulatory  risks  –  Are  there  barriers  beyond  your  ability  to  influence?  FDA?     •  Team  risks  –  Is  our  product  or  customer  knowledge  distributed  and  accessible?     •  Exit  Risk  –  Are  there  willing  buyers  (or  a  public  market)  for  your  company?   19
  • 20. Exit  Strategy  and  Options   •  Length  to  liquidity   •  IPO  vs.  M&A  vs.  Licensing  (vs.  other)   •  Potential  Acquirers   •  Acquirer  characteristics  and  rationale  for  acquisition   •  How  frothy  is  the  current/expected  market  now  and  at  maturity   •  Recent  exits  for  similarly  situated  companies   •  Valuations  (if  available)   •  Counterpoint:  Building  a  company  vs.  building  an  exit   20
  • 21. Summary  Slide  /  Investment  Rationale   •  •  •  •  End  with  a  summary  of  what  you  have  just  said.   Leave  them  with  the  key  message  points  you  are  trying  to  convey.   Be  prepared  for  questions    Appendices   •  All  of  the  information  that  may  backstop  your  conclusions   •  Case  studies   •  Customer  testimonials   •  More  detailed  technical  or  product  information   •  More  detailed  market  or  customer  information     •  Demo  videos   21
  • 22. Financials  and  Projections   •  •  •  •  •  •  •  •  •  •  •  P&L  –  Historical  +  3-­‐5yrs;  Often  with  cash,  customers  and  headcount   Segment  revenue  by  type  of  revenue   Fixed  vs.  Variable  cost  structure   Revenue  and  Margin  Ratios   •  Think  about  cash  flow  timing  issues  –  see  revenue  model  (e.g.,  direct/ reimbursement)   Bottom-­‐Up  vs.  Top-­‐Down  projections   Assumption  tab  in  the  Excel  build   What  does  “conservative”  mean:  Use  of  High  /  Medium  /  Low   Perfect  vs.  Functional  –  Running  your  business  vs.  Building  a  model   Anticipating  investor  cutback   Risks  of  projections  being  tied  to  equity  and  compensation   Valuation  Issues   22
  • 23. General  Dos  and  Don'ts:     “Presentation  is  a  visual  not  a  reference”   Do   •  Use  one  topic  per  slide   Don't   •  Use  sounds  with  slide  transitions   •  Limit  text  on  each  slide   •  Overdo  the  ALL  CAPS,  bolded,   italicized  or  underlined  text   •  Use  pictures,  graphs,  video's   –  Not  all  bullets   •  Use  too  many  different    fonts   •  Choose  fonts  and  colors  that  are  easy   to  read   •  Overuse  special  effects  –  focus  on  the   content   •  PowerPoint  is  the  accessory  to  YOUR   presentation   •  Have  technical  difficulties  –  test  before   the  meeting   •  Spell  Check   23
  • 24. Presentation  Skills:  Part  I   •  Know  your  material  cold!    Don't  wing  it.     •  DON'T  READ  your  presentation.       •  You  should  have  answers  to  likely  questions.   •  Be  clear  when  you  don't  know  an  answer  –  then  follow  up.     •  When  possible,  know  the  room.  Arrive  early,  walk  around  the  speaking  area  and   practice  using  the  microphone  and  any  visual  aids.     •  Body  language  and  appearance  =  50%  of  the  pitch   •  Prioritize  and  eliminate  less  critical  points.       •  Be  flexible  –  be  prepared  to  be  interrupted.     •  Understand  the  goal  of  your  presentation.      Is  it  to  inspire,  to  educate,  to   connect,  to  get  attention,  to  get  a  second  more  personal  meeting?       24
  • 25. Presentation  Skills:  Part  II   •  Modulate  your  pace,  pitch,  volume,  tone  and  enthusiasm  –  like  when  you  are   telling  a  story.    This  helps  keep  the  audience  focused.       •  Use  humor,  personal  stories  and  conversational  language  where  possible.  Use   easy  to  understand  analogies.   •  Practice.  Practice.  Practice!    GO  SEE  OTHER  PRESENTATIONS!   •  Slides  should  HELP  the  oral  presentation,  not  BE  the  presentation.     •  Bring  a  backup  copy  on  a  flash  drive  and  via  cloud     •  Slides  should  be  professional  and  consistent  with  your  image.     •  Spend  more  time  building  the  business  than  the  presentation   •  Leave  time  for  questions.   •  RELAX,  BREATHE  and  SLOW  DOWN   25
  • 26. Interacting  with  Investors   Basic  Principles  -­‐  Overview     •  •  •  •  •  •  •  •  •  •  •  Research  the  investor  in  advance   Pay  attention  to  what  you  say  during  the  presentation  banter   Communicate   Be  likeable     State  your  value  proposition  up  front   Come  prepared  with  sufficient  data  (including  back  up  slides)   Enjoy  yourself  and  let  it  show   Keep  the  presentation  within  allotted  time   Be  realistic  about  valuations  in  the  market   Make  due  diligence  easy   Realize  investors  are  thinking  about  exit  strategy   26
  • 27. •  •  •  •  •  •  •  •  •  •  •  •  Interacting  with  Investors      Cautionary  Overview  –  Don't  do  the  following   Bash  the  competition   Hype   Condescend  or  talk  down   Be  arrogant   Be  vague  about  your  technology     Underestimate  the  importance  of  the  core  science/development   Deluge  investors  with  facts   Act  desperate  for  funding  (even  if  you  are)   Act  like  you  don't  need  money   List  'the  company  is  undervalued'  as  a  reason  to  invest   Overprice  your  rounds  so  you  can  keep  stepping  up  valuation   Give  investors  a  reason  to  turn  you  down   27
  • 28. Life  Science  Venture  Fast  Track   Pitching  the  Plan:  The  Deck Jeremy  Halpern   Partner,  Nutter  McClennen  &  Fish;   Director,  MassVentures   jhalpern@nutter.com   @startupboston   617.439.2943   Dave  Greenwald,  Ph.D.   Founder,  Relay  Technology  Management   Seaport  West,  155  Seaport  Boulevard,  Boston  MA  02210    www.nutter.com