1. Cardiovascular Drugs Ma. Tosca Cybil A. Torres, RN, MAN

3. Antihypertensive

7. o

26. e

27. RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (RAAS) Angiotensinogen in plasma Juxtaglomerular cells-kidney ↓ Serum Sodium ↓Blood volume Angiotensin I Kidney tubules Angiotensin II Adrenal Cortex ↑ Sodium resorption (H2O resorbed with sodium); ↑ Blood volume RENIN Angiotensin-converting enzyme ALDOSTERONE Intestine, sweat glands, Salivary glands Via vasoconstriction of arterial smooth muscle

31. te

42. y

51. Action Potential

53. Inotropes

58. Digoxin MOA

60. Chronotropes

66. Anti-anginal Drugs

72. Symptoms of Angina

76. Drug (Trade Name) Common Dosage Onset Duration Amyl nitrate (Vaporole ® ) 0.3 ml inhalation 30-60 sec 10 min ISDN (Isordil ® ) 2.5 - 10 mg SL 5 - 30 mg po qid 2-5 min 2 - 4 hr Nitroglycerin ( Nitro-bid ® ) 2% ointment 15 min 4 - 8 hr ( Nitrostat ® ) 0.3 - 0.6 mg SL 1-3 min 10 - 45 min ( Nitrogard ® ) 1,2,3 mg XR tab 30 min 8 - 12 hr ( Transderm-Nitro ® ) 2.5 - 15 mg/day Transdermal patch 30-60 min 24 hr

81. Antidysrhythmics Antiarrhythmics

102. Sympathomimetics

105. Epinephrine MOA

108. Vasopressors

115. Anticoagulants

119. Coagulation Cascade

126. Fibrinolytic Enzymes

130. Streptokinase (cont’d)

131. Antilipidemics