Malaria update

Why is Malaria important? ,[object Object],[object Object],[object Object]

Cont… ,[object Object],[object Object]

Malaria Kills more people than AIDS ,[object Object],[object Object],[object Object],[object Object]

Malaria ,[object Object],[object Object]

Malaria Human Malaria is caused by one of protozoan parasites: Plasmodium falciparum Plasmodium vivax Plasmodium ovale Plasmodium malariae Plasmodium knowlesi- forested regions of South East Asia Malaria is transmitted through the bite of an infected female Anopheles mosquito

Life cycle of malarial parasite

Uncomplicated Malaria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Severe Malaria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Parasitological diagnosis of Malaria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Malaria treatment : available drugs ,[object Object],[object Object],[object Object],[object Object],[object Object]

More choices means more confusion !!!

WHO-Current and Future directions “ Drug management of malaria” “ Malaria endemic countries which are experiencing high levels of resistance to currently used anti-malarial drugs as monotherapy are advised to switch over to combination therapy ”

Treatment of Uncomplicated P.Falciparum Infection ,[object Object],[object Object],[object Object]

ACTs Currently recommended by the WHO : Artemether-lumefantrine Artesunate + Amodiaquin Artesunate + Mefloquine, Artesunate + sulfadoxine–pyrimethamine. Dihydrortemisinin + piperaquine Artemesinin –based combination therapies should be used in preference to sulfadoxine-pyrimethamine (sp) + amodiaquine (aq)

2 nd line antimalarial treatment ,[object Object],[object Object],[object Object],[object Object]

Treatment of Severe P.Falciparum ,[object Object],[object Object]

Artemesinine or Quinine for severe falciparum ?? WHO view point : ,[object Object],[object Object]

Artemisinin ,[object Object],[object Object],[object Object]

Side effects? ,[object Object],[object Object],[object Object]

QUININE ,[object Object],[object Object]

Side effects? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Side effects? ,[object Object],[object Object],[object Object],[object Object]

Treatment of P. vivax and P.ovale Infection ,[object Object],[object Object]

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Malaria update

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