1. Benefits of a silica-based fluoride toothpaste
containing
o-cymen-5-ol, zinc chloride and sodium fluoride
2013. 5. 31
발표자 : 폴리클 3 조
17 번 김이산

2. Introduction
People use toothpaste in conjunction with tooth brushing not only to
clean teeth and control the build up of plaque but to gain access to
other oral health benefits
- Anti caries, gum health and malodour control
 Toothpate often contain specific ingredients
- The use of fluoride as an anti-caries agent being the most
wide
spread.

3. Fluoride toothpaste and caries
Cochrane systematic review of fluoride toothpaste
- Supported by more than half a century of research ,
the benefits of fluoride toothpastes are firmly
established.
- The trials are of relatively high quality and provide clear
evidence that fluoride toothpaste are efficacious in
preventing caries.

4. Fluoride toothpaste and caries
Cochrane systematic review of fluoride toothpaste
- 1000ppm fluoride is the minimum concentration that is
the minimum concentration that is proven to be
effective
against caries based on data from caries clinical trials.
- Further, increase in the anti-caries effectiveness of
toothpastes have been associted with increaing
fluoride
concentration.

5. Fluoride toothpaste and caries
 The anti-caries action of fluoride results from its
favourable effect on tooth remineralisation and
demineralisation.
 It is generally accepted that fluoride ions promote
the remineralisation of tooth enamel, increase apatite
structural stability and reduce the rate of
demineralization

6. Fluoride toothpaste and caries
 Several sources of fluoride currently utilised in
marketed
dentifrices.
- NaF , MFP , SnF2 ,
- organic fluorides such as amine fluoride.
 Particularly between the two most widely studied
sources
NaF and MFP.
- NaF dentifrices are slightly more effective than those
employing MFP

7. Toothpaste and gum health
 Plaque-induced gingivitis in the absence of clinical
attachment loss, is the most common form of
periodontal
disease.
 Incorporation of additional antimicrobial actives in
toothpaste as an adjunct to mechanical plaque control
is a convenient way to provide additional protection
against plaque and gingivitis.

8. Toothpaste containing 0.1% o-cymen-5-ol and 0.6%
Zinc chloride.
 These toothpaste provide a convenient way to provide
additional protection for 50-90% of the adult
population
that fits into peoples everyday oral care routines.
 The unique combination of zinc chloride and o-cymen-5
-ol has resulted in a spectrum of antimicrobial activity
greater than for each of the ingredients alone.

9. Toothpaste containing 0.1% o-cymen-5-ol and 0.6%
Zinc chloride.
 When seeking to establish the anti-caries efficacy of a totally New
anti-caries system, a caries clinical trial is desirable.
- However, the high cost and duration of such trials has
led to
the development of alternative methods.
These methods generally described as bioequivalance
studies.
Bioavailable fluoride studies were conducted throughout the
development of the o-cymen-5-ol and zinc chloride toothpaste.

10. Conclusion
 Toothpaste that give additional benefits beyond the primary
reasons for use such as clean teeth plaque control and fluoride
delivery for anti-caries activity shuld be designed not to
compromise these benefits.
 o-cymen-5-ol and zinc chloride can be incorporated into
toothpaste to give addition benefits beyond that of standard
toothpaste without compromise the benefits of a standard
toothpaste