Nsaids

DR.UMA KADAM M.B.B.S. MD ASSOCIATE PROFESSOR PHARMACOLOGY SKNMC

I: Pain and Analgesi cs ,[object Object],[object Object]

Pain pathways ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Pharmacological treatment of pain ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Nonsteroidal Anti-inflammatory Drugs (NSAIDs) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

NSAIDs: ,[object Object],[object Object],[object Object],[object Object]

NSAIDs: Mechanism of Action ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

COX Enzyme:Prostaglandin Effects vasodilation Kidney aggregation Platelets protect mucosa Stomach Modulate pain perception Promote fever (hypothalamus) Brain Inflammation Peripheral injury site COX-2: harmful COX-1: beneficial

Effects of COX Inhibition by Most NSAIDS NSAIDs : anti-platelet—decreases ability of blood to clot COX-1 Gastric ulcers Bleeding Acute renal failure COX-2 Reduce inflammation Reduce pain Reduce fever

CLASSIFICATION OF NSAIDs: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PROTOTYPE: Salicylates (Aspirin) ,[object Object],[object Object],[object Object],[object Object],[object Object]

Pharmacokinetics: ASA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PHARMACOLOGICAL ACTIONS: Aspirin ,[object Object],[object Object],[object Object],[object Object]

PHARMACOLOGICAL ACTIONS: Aspirin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PHARMACOLOGICAL ACTIONS: Aspirin ,[object Object],[object Object],[object Object],[object Object],PGs HCl CTZ ASPIRIN SALICYLIC ACID PEPTIC ULCER EMESIS

[object Object],[object Object],[object Object],[object Object],PHARMACOLOGICAL ACTIONS: Aspirin

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ASPIRIN (NSAIDS):THERAPEUTIC USES

NSAIDs: Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Aspirin (NSAIDs): Side Effects

ASPIRIN (NSAIDs) INTERACTIONS: / Diuretics diuretic response& Probencid / NSAIDs inhibit tubular Antagonize uricosuric effect methotrexate uric acid secretion

NSAIDs: Salicylate Toxicity ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],Aspirin Toxicity - Treatment

ASPIRIN vs PARACETAMOL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Paracetamol (Para-amino phenol derivative) Aspirin (salicylate)

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],PARACETAMOL/ acetaminophen (non-NSAID):

PARACETAMOL ( acetaminophen): ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PARACETAMOL POISONING: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PHARMACOLOGICAL BASIS FOR USE OF N-ACETYLCYSTEINE IN TREATMENT OF PARACETAMOL POISONING: ,[object Object],[object Object],[object Object],[object Object]

COMPARATIVE PHARMACOLOGICAL PROFILE OF NSAIDS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.Phenylbutazone/ ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Diclofenac ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Ibuprofen /Ketoprofen Properties Route & formulations Drug Sr. no

COMPARATIVE PHARMACOLOGICAL PROFILE OF NSAIDS ,[object Object],[object Object],[object Object],[object Object],[object Object],Ketorolac ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Piroxicam ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],2.Metamizole Properties Route & formulations Drug Sr.no

COMPARATIVE PHARMACOLOGICAL PROFILE OF NSAIDS ,[object Object],[object Object],[object Object],[object Object],[object Object],Nimesulide ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Mephenamic acid ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Properties Route & formulations Drug Sr. no.

COMPARATIVE PHARMACOLOGICAL PROFILE OF NSAIDS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Coxibs (etorocoxib, rofecoxib, parecoxib) Properties Route & formulations Drug Sr. no.

Non selective Vs selective COX2 inhibitors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

NSAIDs: Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object]

NSAIDs: Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

NSAIDs: Nursing Implications ,[object Object],[object Object],[object Object]

NSAIDs: Nursing Implications ,[object Object],[object Object]

NSAIDs: Drug Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

NSAIDs: Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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