Potential anticancer componds from natura l sources by Dr.U.Srinivasa, Professor, Srinivas college of pharmacy, Mangalore
1.
2. Cancer is the one of the dreadful disease
which is not yet conquered by man. Scientific
observations and experiences are going on
day and night throughout the world to conquer
this disease. We hope a day will come when the
cancer is within the control of man .That day is
not too long. In this conxet “ Natural bioactive
compounds with anticancer potential ’’
It is to be discussed in length and breadth.
3. * Survey by National cancer registry programme of the Indian
council of medical research ( ICMR) -2011.
* As on March 2011 – 28,00,000 Cancer patients in India.
* Every year 1.2% of cancer patients rises.(an increment of
10,000)
* Every year 5,00,000 peoples dies due to cancer
* Cost of bioactive compounds is very high ,
* Eg- 1gm of vinblastine – US $ 6800
* Eg – 1mg of Withaferin A -£ 69
4. The most common risk factors for cancer are
*Growing older
*Tobacco
*Ionizing radiations
*Certain chemicals and other substances
*Some viruses and bacteria
*Certain hormones
*Family history of cancer
*Alcohol
*Poor diet
*Lack of physical activity OR being overweight
5. Cancer type Total More developed Less developed
countries countries
All 53,17,905 25,03,772 28,14,132
Breast 10,50,346 5,79,285 4,71,063
Colon/ rectum 4,98,574 3,18,694 1,80,059
Kidney 1,18,255 79,090 39,158
Leukemia 1,44,321 58,416 85,912
Liver 3,98,364 73,270 3,25,108
Lung 9,01,746 4,70,836 4,30,919
Melanoma 65,177 50,608 14,571
Oral cavity 1,69,524 59,959 1,09,553
Ovary 1,92,379 91,307 1,01,060
Prostate 5,42,990 4,15,568 1,27,419
Stomach 5,58,458 2,08,282 3,50,176
6. Definition :
Bioactive compounds in plants are the
compounds produced by plant having
pharmacological or toxicological effects.
These bioactive compounds provides
unique lead compounds for drug and drug
development.
They are secondary metabolites.
12. *Nine plant derived compounds have been
approved for use as anticancer drugs ( INDIA)
*Vinblastin
*Vincristine
*Etoposide
*Teriposide
*Taxol
*Navelbine
*Taxotere
*Topotecan
*Irinotecan
14. Before investing time, effort and money in phytochemical
screening it is very important to select a promising plant.
The choice of promising plant depends upon the
following:
1- A plant which have a biological activity.
2- A plant used in folk medicine.
3- A plant which show a particular toxicities.
15. Biological source Local Parts used Preparations
& Family name
Abrus precatorius Gunja Roots and Leaves decoction, flowers internally and
Fabaceae leaves aqueous extract of roots in treatment of
blood cancer
Acacia nilotica Bambri, Stem and Stem and root barks decoction and
Fabaceae babul root barks patients are advised to gargle with this
decoction
Adhatoda vasica Arusa Roots, Juice/extract given internally,
Acanthaceae leaves, plant is burnt and the patients are advised
flowers and to inhale the fume
stem
Aegle marmelos Bael Bark and The roots, leaves, bark and flowers
Rutaceae flower decoction
Alangium salviifolium Ankol Roots, bark Bark decoction or boil the fresh bark in
Alangiaceae and fruits base oil to prepare special oil is
considered beneficial for the cancerous
wound, fruits for lung cancer
16. Albizia lebbeck Sirsa Flower and Flowers in form of aqueous extract applied
Fabaceae bark externally and bark in the form of powder
given internally
Anthocephalus Kadam Fruits and Consuming Kadam fruits during growing
cadamba leaves season, dried leaves powders internally
Rubiaceae
Artocarpus Kathal Seed, bark Few pinches of root powder are given
heterophyllus and roots internally and the roots decoction
Moraceae
Astercantha ongifolia Mokhla Root Aqueous extract
Acanthaceae
Balanites aegyptiaca Hingot Bark and Dried bark powder, fruits pulps for blood
Balanitaceae fruits cancer
Bambusa sp. Bans Leaves, bark Leaf juice and bark decoction internally,
Poaceae and seed seeds with Shahad (Honey).
Bauhinia variegata Son Flower and Flower given with cow milk, leaves
Fabaceae Patta leaves decoction
Buchanania lanzan Char Seed, bark Roots are used in form of dry powder, in
Anacardiaceae and root form of decoction, bark powder with cow
milk and honey
17. Butea monosperma Parsa Leaves and Leaf juices & fruit powder.
Fabaceae fruits
Calotropis gigantea Fudhar Root and Root decoction for lung cancer and
Asclepiadaceae latex roots are dipped in its latex, burnt and
patients are advice to inhale it
Cannabis sativa Bhang Leaves The leaves are crushed and with the
Cannabaceae help of cow milk an aqueous paste is
prepared. This paste is applied
externally on the wound
Cassia fistula Dhanbaher Leaves and Leaf juice in treatment of cancerous
Fabaceae fruits wound, The fruit pulp is boiled in water
to prepare concentrate decoction given
internally
Citrus medica Bijaura Fruit, seed, Dried fruits powder, root in the form of
Rutaceae bark and root paste, bark in the form of decoction
Coriandrum sativum Dhania Seed and Boil the seed powder in water to
Apiaceae whole herbs prepare concentrate decoction. The
patients are advised to gargle with this
decoction, whole herb juice advised to
take it internally
Curcuma sp. Haldi Rhizome Both internally as well as externally in
Zingiberaceae treatment of cancer
18. Datura species Dhatra Leaf and flower Dhatura leaf juice, opium and sonth
Solanaceae (Dried Ginger) and in form of paste
applied this combination on
cancerous wound
Diospyros elanoxylon Tendu Fruits and bark Bark paste with cow milk
Ebenaceae
Embelia ribes Baibirang Leaves, Roots Leaves are used externally in form
Euphorbiaceae and fruits of decoction and paste
Emblica officinalis Aonla, amala Leaf, roots and Leaf juices, root boil in mustard oil
Euphorbiaceae bark for cancerous wound
Euphorbia neriifolia Thura Latex and Fresh latex and leave extract
Euphorbiaceae leaves
Ficus benghalensis Bargad Bark, root and Barks of Bar, Maharukh (Ailanthus
Moraceae , fresh latax excelsa) and Neem (Azadirachta
indica) and prepare the
combination, fresh latex internally
Ficus glomerata Doomar Leaves, bark Leaves juice bark juice, dried root
Moraceae. and roots powder given internally
19. Ficus religiosa Pipal Leaves Leaf extract
Moraceae and fruits
Gloriosa superba Kalihari Bulb, Freshly collected bulbs are crushed and
Colchicaceae leaves and added in mustard seed oil. The combination
seeds is boiled and when all watery contents
evaporate the boiling is stopped and special
oil is used after filtration. The special oil is
considered beneficial for the cancerous
wound, The leaves are given internally in
form of juice
Gmelina arborea Khamhar Leaves Leaves juice, dried fruits powder
Lamiaceae and fruits
Hibiscus rosasinensis Jason Flowers Dried flower powder
Malvaceae
Mangifera indica Ama Leaves The leaves of Arusa (Adhatoda vasica),
Anacardiaceae and inner Kukurmutta (Blumea lacera) and Chirchita
bark (Achyranthes aspera) are mixed in equal
proportion. The Ama leaves are taken in
double amount of this combination and
mixed thoroughly. The combination is burnt
and the patients are advised to inhale the
fumes for lung cancer
20. Melia azedarach Bakain Root, bark and Dried root powder is given
Meliaceae fruits internally, inner bark and extract
the juice given internally
Moringa oleifera Munga Bark, flowers Bark decoction, dried flowers
Moringaceae powder
Mucuna pruriens Kevatch Root, seed Patients having mouth cancer to
Fabaceae and whole always put the freshly collected
herbs Kevatch root inside the mouth,
seed powder useful in treatment of
cancer pain
Nerium odorum Kaner Root and Roots decoction is prepared. The
Apocynaceae flowers patients are advised to wash the
wound with the help of this
decoction
Nyctanthes arbor- Harshringar Leaves and Dried bark powder given internally,
tristis bark leaves decoction
Oleaceae
Ocimum sanctum Tulsi Seed and Decoction of seed and leaves
Lamiaceae leaves internally
21. There is a research gap on this topic still exist.
This gap should be filled by quality researchers.
The whole world is weighting for search
research
