Cannabinoids Jonny A.

MARIJUANA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HISTORY ,[object Object],[object Object],[object Object],[object Object],Cannabis from Vienna Dioscorides

NAMES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CANNABIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Different varieties of Cannabis

HASHISH ,[object Object],[object Object],[object Object],[object Object]

THC ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ADVANCES IN CANNABINOID RESEARCH ,[object Object],[object Object],[object Object],[object Object],[object Object], 9 -tetrahydrocannabinol Anandamide – Binds to CB 1 R

Endocannabiniods: 2-AG (2-arachidonoylglycerol) and AEA (anandamide) are synthesized in post-synaptic cells and are not released from vesicles Ca 2+ Ca 2+ degradation degradation AEA 2-AG biosynthesis biosynthesis 2 nd Messenger CB 1 R GPCR G G Post-synaptic Pre-synaptic Modified Figure from R.D. Hosking and J.P. Zajicek. 2008. Therapeutic potential Of cannabis in pain medicine. British Journal of Anaesthesia. 101:59-68.

Endocannabinoids: Involved in retrograde signaling – bind to CB receptors (CBRs), which are G protein coupled receptors Ca 2+ Ca 2+ degradation degradation AEA 2-AG biosynthesis biosynthesis 2 nd Messenger CB 1 R GPCR G G Post-synaptic Pre-synaptic

Cannabinoid binding to CB 1 R inhibits Ca 2+ channels in pre-synaptic cell Ca 2+ Ca 2+ degradation degradation AEA 2-AG biosynthesis biosynthesis 2 nd Messenger CB 1 R GPCR G G Post-synaptic Pre-synaptic

DEGRADATION OF ENDOCANNABINOIDS Ca 2+ Ca 2+ degradation degradation AEA 2-AG biosynthesis biosynthesis 2 nd Messenger CB 1 R GPCR G G Post-synaptic Pre-synaptic

THERAPEUTIC TARGETS IN ENDOCANNABINERGIC NEURONS Ca 2+ Ca 2+ degradation degradation AEA 2-AG biosynthesis biosynthesis 2 nd Messenger CB 1 R GPCR G G Post-synaptic Pre-synaptic

EFFECTS OF MARIJUANA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

DISTORED PERCEPTIONS ,[object Object]

IMPAIRED LEARNING ,[object Object],2 + 2 = 5

MUNCHIES ,[object Object],[object Object],American Dad: Clip

ANXIETY AND PARANOIA ,[object Object]

INCREASED HEARTRATE ,[object Object]

Altered Sense of Time ,[object Object]

BLOODSHOT EYES ,[object Object]

MEDICAL MARIJUANA ,[object Object],[object Object],[object Object]

MARINOL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

LEGAL ISSUES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SOCIAL ISSUES ,[object Object],[object Object],[object Object],[object Object],[object Object]

ECONOMIC ISSUES ,[object Object],[object Object],[object Object],[object Object]

MARIJUANA AND RELIGION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ADVANCES IN CANNABINOID RESEARCH ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object], 9 -tetrahydrocannabinol Anandamide – Binds to CB 1 R

Cannabinoids Jonny A.

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Cannabinoids Jonny A.