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Drugs and the Brain Part 3 Opiates: A Brief History

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Drugs and the Brain Part 3 Opiates
An Introduction ,[object Object],[object Object]
What are Opiates? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Opiate History ,[object Object],[object Object],[object Object],[object Object]
Opiate History (continued) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Opium Wars ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Opium Wars (continued) ,[object Object],[object Object],[object Object],[object Object]
The Second Opium War ,[object Object],[object Object],[object Object],[object Object]
Medicinal Opium ,[object Object],[object Object],[object Object]
Medicinal Opium (continued) ,[object Object],[object Object],[object Object],[object Object],[object Object]
The Active Ingredient ,[object Object],[object Object],[object Object]
Changing Attitudes ,[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Development Continues ,[object Object],[object Object],[object Object],[object Object]
Morphine & Heroin
Mechanism of Action ,[object Object],[object Object],[object Object],[object Object],[object Object]
Agonists and Antagonists ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Opiate Antagonists ,[object Object],[object Object],[object Object],[object Object]
Discovery of the Opiate Receptor ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
How Opiates Work ,[object Object],[object Object],[object Object],[object Object],[object Object]
Distribution of Opiate Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Distribution of Opiate Receptors The distribution of opiate receptors in the brain of a guinea pig.  Red areas = highest density; yellow = moderate density, blue, purple & white = low density.  
Types of Opiate Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Role of Receptor Types ,[object Object],[object Object],[object Object],[object Object]
Addiction to Opiates ,[object Object],[object Object],[object Object],[object Object]
Pathway of Addiction ,[object Object],[object Object],[object Object],[object Object],[object Object]
Dopamine & Opiate Addiction ,[object Object],[object Object],[object Object]
A Synapse in the Nucleus Accumbens .
Tolerance to Opiates ,[object Object],[object Object],[object Object],[object Object]
Tolerance & the Brain ,[object Object],[object Object],[object Object]
Dependence on Opiates ,[object Object],[object Object],[object Object]
The Brain’s Morphine ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Drugs and the Brain Part 3 Opiates: A Brief History

  • 1. Drugs and the Brain Part 3 Opiates
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  • 21. Distribution of Opiate Receptors The distribution of opiate receptors in the brain of a guinea pig.  Red areas = highest density; yellow = moderate density, blue, purple & white = low density.  
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  • 27. A Synapse in the Nucleus Accumbens .
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