The document discusses veterinary oral surgery techniques for treating fibrosarcoma, melanoma, and other cancers in animals. It describes procedures like rostral mandibulectomy and bilateral rostral maxillectomy to remove tumors from the mouth. Other techniques mentioned include split palatal U flaps, labial advancement flaps, and bilateral release grafts for hard and soft palatal clefts. Information and images are courtesy of several veterinary dental experts.
Oral SCC Therapy: Single modality therapy = 60-90 days NC Postorino et al; JAHHA Sept ‘93 Mandibulectomy and RT = 12-14 months CA Hutson et al; JAVMA Sept ‘92 Controversial amongst oncologists Not been able to be reproduced Most oncologists feel median survival = 4-6 months Tri-modality therapy (sx/RT/chemo) Being investigated presently Anecdotally appears to be 6-9 months 1 year survival rarely exceeds 10% in cats following any modality.
Oral SCC Generally POOR - GRAVE prognosis Human HNSCC (head & neck SCC) Also extremely invasive w/poor prognosis Overexpress EGFR (epidermal growth factor receptor) Increased growth rate Increased chemoresistance Increased radioresistance EGFR inhibitors alone in people = responses EGFR inhib + chemo/RT = dramatic responses