1. Journal reading Recent Development in the diagnosis and management of Sepsis ( Chest 2007;132:1968-1976) 2008/1/24 報告： R1 林軒名 醫師 指導： VS 涂智彥 醫師

12. The STOP sepsis bundle

13. The STOP sepsis bundle

14. The STOP sepsis bundle

15. 24hrs later, STOP sepsis

16. 24hrs later, STOP sepsis

19. Inappropriate antibiotics The influence of inadequate empirical antimicrobial treatment on patients with bloodstream infections in an intensive care unit ( Clin Microbiol Infect 2003; 9: 412–418)

22. Early goal-directed therapy

29. 24hrs later, STOP sepsis

30. 24hrs later, STOP sepsis

33. Survival of Patients With Septic Shock of non-responders Effect of Treatment With Low Doses of hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock( JAMA. 2002;288:862-871)

34. Survival of Patients With Septic Shock of all patient Effect of Treatment With Low Doses of hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock( JAMA. 2002;288:862-871)

37. Kaplan–Meier Curves for Survival at 28 Days Hydrocortisone Therapy for Patients with Septic Shock ( NEJM 2008;358:111-24.)

38. Kaplan–Meier Curves for the Time to Reversal of Shock P = 0.06 Hydrocortisone Therapy for Patients with Septic Shock ( NEJM 2008;358:111-24.)

43. Results Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis ( N Engl J Med 2008;358:125-39.)

44. Results Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis ( N Engl J Med 2008;358:125-39.)

46. Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis ( NEJM 2001;344:699-709)

49. The STOP sepsis bundle

50. The STOP sepsis bundle

51. The STOP sepsis bundle

52. 24hrs later, STOP sepsis

53. 24hrs later, STOP sepsis

55. Thanks for your attention

56. Inflammatory Responses to Sepsis Management of Sepsis ( NEJM 2006;355:1699-713.)

57. Procoagulant Response in Sepsis Management of Sepsis ( NEJM 2006;355:1699-713.)

58. Pathways and Mediators of Sepsis Management of Sepsis ( NEJM 2006;355:1699-713.)

59. Pathways and Mediators of Sepsis Management of Sepsis ( NEJM 2006;355:1699-713.)

60. Results of Positive Randomized, Controlled Trials Management of Sepsis ( NEJM 2006;355:1699-713.)

61. Risk factor of sepsis Sepsis (AJM (2007) 120, 1012-1022)

64. Low-Tidal-Volume Ventilation in the ARDS Low-Tidal-Volume Ventilation in the ARDS ( NEJM 2007;357:1113-20.)

65. Risk factor of sepsis Sepsis (AJM (2007) 120, 1012-1022)

66. SOAP study Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study*(Crit Care Med 2006; 34:589–597)

67. SOAP study Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study*(Crit Care Med 2006; 34:589–597)

68. Shock in any course Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study*(Crit Care Med 2006; 34:589–597)

69. Septic shock Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study*(Crit Care Med 2006; 34:589–597)

70. Comparison of Two Fluid-Management Strategies in Acute Lung Injury

71. Comparison of Two Fluid-Management Strategies in Acute Lung Injury