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Making Drugs Smarter

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V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

A micelle consists of a single lipid monolayer characterized by a thin shell and small particle size usually <100nm A liposome consists of phospholipid bilayers that are characterized by a thicker shell and larger particle size 10nm particle size nanotechnology 1micron particle size V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

a novel drug delivery vehicle can be more than just simple particles composed of lipids… V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

improved bioavailability and effectiveness of naïve drugs… … a drug can maintain its stability in the body by means of nanoencapsulation while achieving increased bioavailability by small particle manipulation. DNA is an example of a targeted vehicle with small particle size, <100nm. *Image © Dennis Kunkel Microscopy, Inc. * V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

Targeting a specific cell, cell receptor or cell wall can promote better delivery to engage a more pronounced therapeutic effect V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

an inner diverse look into science V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

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DEFENITION: Drug delivery systems are designed to enhance the targeted delivery of medications, improving their effectiveness while minimizing side effects. Various approaches include nanoparticles, liposomes, and implantable devices, offering controlled release or targeted delivery to specific tissues. These systems aim to optimize therapeutic outcomes and patient compliance. CLASSIFICATION OF DRUG DELIVERY SYSTEM Oral Drug Delivery:- Tablets, capsules, and liquids are commonly used for systemic drug delivery. Controlled-release formulations provide sustained drug release over time Injectable Drug Delivery:- Intravenous, intramuscular, and subcutaneous injections allow rapid drug delivery into the bloodstream. Depo injections provide sustained release over weeks or months. Transdermal Drug Delivery:- Patches and topical formulations deliver drugs through the skin. Ensures a controlled and prolonged release of medication. Inhalation Drug Delivery:- Aerosolized medications for respiratory conditions. Rapid absorption through the lung's extensive surface area. Implantable Drug Delivery:- Devices like pumps or reservoirs placed under the skin for continuous drug release. Common for long-term conditions requiring a steady dosage. Nanoparticle-based Drug Delivery:- Nanocarriers (liposomes, micelles, nanoparticles) enhance drug solubility and improve targeted delivery. Effective for delivering drugs to specific cells or tissues. Targeted Drug Delivery:- Ligand-based systems use specific molecules to target drugs to particular cells or tissues. Minimizes side effects by focusing on diseased areas. Gastrointestinal Drug Delivery:- Drug formulations designed for specific release in different parts of the gastrointestinal tract. Examples include enteric-coated capsules. Intrathecal Drug Delivery:- Direct delivery of drugs into the spinal canal. Often used for pain management or neurological conditions. Ocular Drug Delivery:- Eye drops, ointments, or implants for treating ocular conditions. Ensures targeted drug delivery to the eyes. These systems cater to diverse medical needs, offering tailored solutions for optimal therapeutic outcomes.

ocular drug delivery systems in drug delivery systems

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ocular drug delivery systems in drug delivery systems

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ocular barriers and methods to overcome barriers

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They are specialized dosage forms designed to be instilled onto the external surface of the eye(topical), administered inside(intraocular) or adjacent(periocular) to the eye, or used in conjunction with an ophthalmic device. The novel approach of drug delivery system in which drug can instill on the cull de sac cavity of the eye is known as ocular drug delivery system. APPROACHES TO IMPROVE OCULAR DRUG DELIVERY: Viscosity enhancer Eye ointments Prodrugs Penetration enhancer Mucoadhesives In-situ gel Nanoemulsion Implants Microemulsion Liposomes Niosomes Nanoparticles

Approaches to overcome the barriers of Ocular drug delivery systems

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Eye diseases are commonly encountered in day to day life, which are cured or prevented through the conventionally used dosage forms. Delivery to the internal parts of the eye still remains troublesome due to the anatomical and protective structure of the eye. Drugs may be delivered to the eye through the application of four primary modes of administration: topical, systemic, intravitreal, and periocular.

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1. V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

2. A micelle consists of a single lipid monolayer characterized by a thin shell and small particle size usually <100nm A liposome consists of phospholipid bilayers that are characterized by a thicker shell and larger particle size 10nm particle size nanotechnology 1micron particle size V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

3. a novel drug delivery vehicle can be more than just simple particles composed of lipids… V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

4. Combining a drug with a thin layered micelle enhances the stability and integrity of the drug while maintaining a fast and effective pk profile. fast and effective V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

5. Combining a drug with a bilayered liposome enhances the stability and integrity of the drug while maintaining a sustained and basal pk profile. sustained V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

6. Combining a drug with a micelle, liposome or micelle-lipocomplex enhances the stability, integrity and pk profile… … further comprising the drug delivery vehicle with an intelligent augmentation can increase a drugs pharmacodynamics by focusing on specific cell targets . targeted V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

7. improved bioavailability and effectiveness of naïve drugs… … a drug can maintain its stability in the body by means of nanoencapsulation while achieving increased bioavailability by small particle manipulation. DNA is an example of a targeted vehicle with small particle size, <100nm. *Image © Dennis Kunkel Microscopy, Inc. * V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

8. Targeting a specific cell, cell receptor or cell wall can promote better delivery to engage a more pronounced therapeutic effect V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®

9. an inner diverse look into science V I R U N safe & effective oral delivery © 2009 VIRUN all rights reserved ®