Fruits and vegetables contain vitamins and minerals that help fight cancer. The top 5 cancers in the United States are skin, lung, prostate, breast, and colorectal cancer. In Pennsylvania, the most common cancers are lung cancer, breast cancer, and prostate cancer, affecting over 77,450 people annually. Tobacco use, diet, obesity and genetics are leading causes of cancer. Making lifestyle changes like not smoking, eating healthy, limiting alcohol and staying active can help prevent and reduce risk of cancer.