Diuretic strategies in patients with acute decompensated

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Diuretic Strategies in Patients with Acute Decompensated Heart Failure G.Michael Felker, M.D. The New England Journal of Medicine March 2011 Warawut Suttison ,MD

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Method ,[object Object],[object Object],Low dose High dose (2.5 times) intravenous bolus every 12 hours continuous intravenous infusion

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[object Object],Results Bolus Infusion P-value require a dose increase at 48 hours 21% 11% 0.01 switch to oral diuretics at 48 hours 22% 26% 0.44 median total dose 592 mg 480 mg 0.06 primary efficacy end point no significant primary safety end point no significant secondary end points no significant Serum creatinine and cystatin C levels similar

Results ,[object Object],Low High P-value change to oral diuretics at 48 hours 17% 31% < 0.001 require a 50% increase in the dose at 48 hours 24% 9% 0.003 median total dose 358 mg 773 mg < 0.001 primary efficacy end point no significant primary safety end point no significant secondary end points 23% 14% 0.04 Serum creatinine and cystatin C levels no significant

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Diuretic strategies in patients with acute decompensated

1. Diuretic Strategies in Patients with Acute Decompensated Heart Failure G.Michael Felker, M.D. The New England Journal of Medicine March 2011 Warawut Suttison ,MD

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