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Stat3 protein & t helper 17 cell -in psoriasis by yousry a mawla
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M.YOUSRY Abdel-Mawla
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Stat3 protein & t helper 17 cell -in psoriasis by yousry a mawla
1.
STAT 3&
TH17 CELL in PSORIASIS M.YOUSRY ABDEL-MAWLA,MD Zagazig Faculty of Medicine,Egypt
2.
3.
Cytokines and growth
factors that activate STAT proteins
4.
5.
6.
7.
8.
9.
Regulation of the
STAT3 signal transduction pathway
10.
Regulation of intracellular
Stat3 signalling .
11.
12.
13.
Effects of STAT3
Deficiency on Cellular Function Stuart et al.T he Journal of Immunology, 2009, 182: 21–28
14.
Psoriasis
15.
16.
17.
Psoriasis Clinical Presentation
18.
Clinical Manifestations
of Psoriasis
19.
20.
21.
22.
23.
24.
25.
Immunopathology of Psoriasis
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
Proinflammatory Effects
of IL17
36.
Roles of
IL-23 on T Helper 17 cells in Chronic Inflammation in Psoriasis Adapted from Iwakura & Ishigame, J Clin Invest 116:1218-1222 (2006) Dendritic cell Macrophage IL-23 IL-12 Th1 Th17 IFN IL-1, IL-6 TNF Inflammatory response Endothelial cells Stromal cells Epithelial cells Fibroblasts Macrophage IL-17, IL-6 IL-1 IL-6 IL-8 TNF IL-12R IL-23R IL-23R
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
A Tender
Piece of Information
49.
50.
Studies on Stat
3 in Psoriasis
51.
Stat 3 in
Psoriasis
52.
53.
54.
New Prospectives &Directions
55.
56.
Manipulation of Psorasis
57.
Therapeutic Targets in
Psoriasis As a T Helper 17 Cell-Mediated Disease
58.
Anti TNF approved
for psoriasis treatment JEADV 2010, 24 (Suppl. 5), 2–24
59.
60.
61.
62.
63.
64.
Current Rheumatology Reports
2007 , 9:461–467
65.
Message Home
66.
67.
68.
THANK YOU