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Stat3 protein & thelper 17 cell in psoriasis

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M.YOUSRY Abdel-Mawla
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Signal Transducer &Activator of Transcription( STAT)-3 & T Helper (Th) 17 Cell in Psoriasis ,[object Object],[object Object]
Signal transducers and activators of transcription ) Stat) Family ,[object Object],[object Object],[object Object]
 
 
STAT3 Activation ,[object Object],[object Object],[object Object]
Mechanism of Stat3 signaling ,[object Object]
Psoriasis
Psoriasis ,[object Object],[object Object]
Psoriasis Clinical Presentation
Psoriasis as an immune disorder
Prepsoriasis State
Prepsoriasis State
Development of Psoriasis
Immunopathology of Psoriasis
T-Cell in Psoriasis
T helper 1 versus 2 in psoriasis ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
T helper cell precursors being skewed towards Th1, Th2, Th17 and T regulatory cell (Treg) phenotypes on the basis of the cytokine environment . 
PSORIASIS IS A Th17 DISEASE :A Hypothesis ,[object Object],[object Object],[object Object]
PSORIASIS IS A Th17 DISEASE ,[object Object],[object Object],[object Object],[object Object]
 
Microbial Antigens & Th 17 Response ,[object Object]
ACTIVATION of T h 17 &STAT3 ,[object Object],[object Object],[object Object]
STAT3 REGULATION of CYTOKINE-MEDIATED GENERATION of TH 17 ,[object Object],[object Object],[object Object],[object Object]
 
Proinflammatory Effects of IL17
Stat3 links activated keratinocytes and immunocytes required for development of psoriasis ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
New Informations
 
Do Other Therapies Work Within This Framework? ,[object Object],[object Object]
Studies on Stat 3 in Psoriasis
Stat 3 in Psoriasis
 
 
New Prospectives &Directions
 
Manipulation of Psorasis
 
Therapeutic Targets ( Fitch et al , Current Rheumatology Reports 2007, 9: 461–467 ) Fitch et al.
Message Home
Message Home ,[object Object],[object Object]
THANK YOU

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Stat3 protein & thelper 17 cell in psoriasis