SlideShare une entreprise Scribd logo
1  sur  74
黃


    1
狀




www.doctorwong.net 黃
                       2
3
+
4

        4
1.
 	
 	
 	
 	
 	



      www.doctorwong.net 黃
                             5
1.
 	
 	




      www.doctorwong.net 黃
                             6
1.
 	
 	




      www.doctorwong.net 黃
                             7
8
狀


	



     www.doctorwong.net 黃
                            9
?




          10

                 10
狀
狀




    www.doctorwong.net 黃
                           11
www.doctorwong.net 黃
                       12
狀
                       狀


                           狀




www.doctorwong.net 黃
                               13
狀




    14
徵


•




        www.doctorwong.net
                             15
徵
•   	

•        	
•
•

              www.doctorwong.net
                                   16
1      :



    2


    3



•
        www.doctorwong.net 黃
                               17
4



    5



    6




•
        www.doctorwong.net 黃
                               18
7




8   /




        www.doctorwong.net 黃
                               19
9


10




     www.doctorwong.net 黃
                            20
www.doctorwong.net 黃
                       21
www.doctorwong.net 黃
                       22
癥狀




     23
徵
    	
•
•
•
•
•
•
•

             www.doctorwong.net
                                  24
徵
    	
•
•
•
•
•
•
•

             www.doctorwong.net
                                  25
徵
    	
•
•
•
•                 黃
•                     晚

•
•

             www.doctorwong.net
                                  26
徵
    	

•
•
•
•



             www.doctorwong.net 黃
                                    27
28
狀




www.doctorwong.net 黃
                       29
www.doctorwong.net 黃
                            30
Alzheimer's Disease
                            50%




Other Causes                           Mixed Alzheimer's/ Vascular Disease
    10%                                               10%




                                           Vascular Disease
                                                 10%
        Dementia with Lewy Bodies
                  20%
                                                 After Perry et al. 1989, 1990


                                                                                 31
32
狀




    33
狀




    34

         34
35
                         徵狀


              狀





    www.doctorwong.net
                         36

                               36
www.doctorwong.net
                     37

                          37
38
辦
•

•
•
•




    www.doctorwong.net 黃
                               39
1.
     歷   狀

2.


3.


4.
             40
•       歷
•
•
•
    •       哪




                41
懂   懂




        42
*               *
*   狀           *  X
                *?
•       B12
                •
•               •
•
*               •       CT Brain)
*               •        MRI )
                • PET
                • SPECT
              www.doctorwong.net 黃

                                     43
44
徵狀


 www.doctorwong.net 黃
                        45
   狀






        www.doctorwong.net 黃
                               46
酶


酶



    www.doctorwong.net 黃
                           47
•




    www.doctorwong.net 黃
                           48
                               cholinesterase
                         acetylcholine
                            acetylcholine







   Rivastigmine / Galantamine / Donepezil


    www.doctorwong.net
                                                 49

                                                      49
酶
•

•
•
•   癥狀




     www.doctorwong.net 黃
                            50
徵狀
           狀

1.

2.



     www.doctorwong.net 黃
                            51










    52

         52
          +
          +           +
      +       +
   
   
   
      +
          +       +

                            53

                                 53
www.doctorwong.net 黃
                       54
(Nootropics)


    – SERMION 5mg –10mg BD to 30mg OM


    – Gingko Biloba
    – Piracetam




    www.doctorwong.net
                                   55

                                        55
/            E





   1000 iu BD (400iu – 800iu BD)




    www.doctorwong.net
                                    56

                                         56
Memantine
   NMDA        N-methyl-D-aspartate receptor
                  glutamate


   Memantine   NMDA


   ?





                       www.doctorwong.net
                                            57

                                                 57



 Dementia   Care Mapping



                 www.doctorwong.net
                                      58

                                           58
59
•

•
              癥



    www.doctorwong.net 黃
                           60
拖




www.doctorwong.net 黃
                       61
尬




    www.doctorwong.net 黃
                           62
懂




www.doctorwong.net
                     63
64
•

•
•
•
•   酗
•


        www.doctorwong.net 黃
                               65
Q2
        	
                                   ?





    –
    –
    –


    –
    –
                   www.doctorwong.net   66

                                                 66
Q3           	
 
	
                                                     ?
      
          –
          –       E
          –
          – ? NSAID (                      )
      
          –
          –
          –
          –

                             www.doctorwong.net   67

                                                           67
嗎
–
–
–
       =
    

–
           :
    

    




                    68

                         68
Q5               ?









    www.doctorwong.net


                             69

                                  69
Q5              ?

         =
    – > 65
    – < 1%
    –      1, 14 + 21



              www.doctorwong.net
                                       70

                                            70
嗎




                       PS1, PS2 Presenilin (Chr 1,14)
                       APP Amyloid Precursor Gene (21)


www.doctorwong.net 黃   APOE : Chromosome 19
                                                     71
   1/3                 =
    (Javick)
      –
      –
      –
      –
      –
      –
      –
      –

                     2       

                                 72

                                      72
狀
•       
   
       
           

    
•       
   
                            
         
•                          

    
             
•                                    
•               

                   
                 


                        www.doctorwong.net 黃
                                                           73
74

Contenu connexe

Plus de Yvonne 99

南極企鵝
南極企鵝南極企鵝
南極企鵝Yvonne 99
 
60歲後回味 美麗世界
60歲後回味 美麗世界60歲後回味 美麗世界
60歲後回味 美麗世界Yvonne 99
 
唯一一隻登上時代雜誌封面的狗狗
唯一一隻登上時代雜誌封面的狗狗唯一一隻登上時代雜誌封面的狗狗
唯一一隻登上時代雜誌封面的狗狗Yvonne 99
 
只能陪你一程 -(Rev)
只能陪你一程 -(Rev)只能陪你一程 -(Rev)
只能陪你一程 -(Rev)Yvonne 99
 
向野雁學習
向野雁學習向野雁學習
向野雁學習Yvonne 99
 
花販告訴我
花販告訴我花販告訴我
花販告訴我Yvonne 99
 
生命中的旅程
生命中的旅程生命中的旅程
生命中的旅程Yvonne 99
 
故宮國畫
故宮國畫故宮國畫
故宮國畫Yvonne 99
 
From moscow to beijing by train
From moscow to beijing by trainFrom moscow to beijing by train
From moscow to beijing by trainYvonne 99
 
三種感情
三種感情三種感情
三種感情Yvonne 99
 
很好的短信
很好的短信很好的短信
很好的短信Yvonne 99
 
福不可受盡
福不可受盡福不可受盡
福不可受盡Yvonne 99
 
忍辱息瞋篇
忍辱息瞋篇忍辱息瞋篇
忍辱息瞋篇Yvonne 99
 
超越痛苦 - 黃慧英
超越痛苦 -  黃慧英超越痛苦 -  黃慧英
超越痛苦 - 黃慧英Yvonne 99
 
甚麼是幸福的人生? / 釋衍空
甚麼是幸福的人生?  / 釋衍空甚麼是幸福的人生?  / 釋衍空
甚麼是幸福的人生? / 釋衍空Yvonne 99
 
緣盡時要懂得放下
緣盡時要懂得放下緣盡時要懂得放下
緣盡時要懂得放下Yvonne 99
 
Mbsr effectiveness in HK
Mbsr effectiveness in HKMbsr effectiveness in HK
Mbsr effectiveness in HKYvonne 99
 
Mindfulness Based Stress Reduction
Mindfulness Based Stress ReductionMindfulness Based Stress Reduction
Mindfulness Based Stress ReductionYvonne 99
 

Plus de Yvonne 99 (20)

南極企鵝
南極企鵝南極企鵝
南極企鵝
 
60歲後回味 美麗世界
60歲後回味 美麗世界60歲後回味 美麗世界
60歲後回味 美麗世界
 
唯一一隻登上時代雜誌封面的狗狗
唯一一隻登上時代雜誌封面的狗狗唯一一隻登上時代雜誌封面的狗狗
唯一一隻登上時代雜誌封面的狗狗
 
Friendship
FriendshipFriendship
Friendship
 
只能陪你一程 -(Rev)
只能陪你一程 -(Rev)只能陪你一程 -(Rev)
只能陪你一程 -(Rev)
 
向野雁學習
向野雁學習向野雁學習
向野雁學習
 
花販告訴我
花販告訴我花販告訴我
花販告訴我
 
生命中的旅程
生命中的旅程生命中的旅程
生命中的旅程
 
故宮國畫
故宮國畫故宮國畫
故宮國畫
 
From moscow to beijing by train
From moscow to beijing by trainFrom moscow to beijing by train
From moscow to beijing by train
 
三種感情
三種感情三種感情
三種感情
 
笑笑
 
很好的短信
很好的短信很好的短信
很好的短信
 
福不可受盡
福不可受盡福不可受盡
福不可受盡
 
忍辱息瞋篇
忍辱息瞋篇忍辱息瞋篇
忍辱息瞋篇
 
超越痛苦 - 黃慧英
超越痛苦 -  黃慧英超越痛苦 -  黃慧英
超越痛苦 - 黃慧英
 
甚麼是幸福的人生? / 釋衍空
甚麼是幸福的人生?  / 釋衍空甚麼是幸福的人生?  / 釋衍空
甚麼是幸福的人生? / 釋衍空
 
緣盡時要懂得放下
緣盡時要懂得放下緣盡時要懂得放下
緣盡時要懂得放下
 
Mbsr effectiveness in HK
Mbsr effectiveness in HKMbsr effectiveness in HK
Mbsr effectiveness in HK
 
Mindfulness Based Stress Reduction
Mindfulness Based Stress ReductionMindfulness Based Stress Reduction
Mindfulness Based Stress Reduction
 

Dernier

4.18.24 Movement Legacies, Reflection, and Review.pptx
4.18.24 Movement Legacies, Reflection, and Review.pptx4.18.24 Movement Legacies, Reflection, and Review.pptx
4.18.24 Movement Legacies, Reflection, and Review.pptxmary850239
 
Field Attribute Index Feature in Odoo 17
Field Attribute Index Feature in Odoo 17Field Attribute Index Feature in Odoo 17
Field Attribute Index Feature in Odoo 17Celine George
 
Q4-PPT-Music9_Lesson-1-Romantic-Opera.pptx
Q4-PPT-Music9_Lesson-1-Romantic-Opera.pptxQ4-PPT-Music9_Lesson-1-Romantic-Opera.pptx
Q4-PPT-Music9_Lesson-1-Romantic-Opera.pptxlancelewisportillo
 
Textual Evidence in Reading and Writing of SHS
Textual Evidence in Reading and Writing of SHSTextual Evidence in Reading and Writing of SHS
Textual Evidence in Reading and Writing of SHSMae Pangan
 
GRADE 4 - SUMMATIVE TEST QUARTER 4 ALL SUBJECTS
GRADE 4 - SUMMATIVE TEST QUARTER 4 ALL SUBJECTSGRADE 4 - SUMMATIVE TEST QUARTER 4 ALL SUBJECTS
GRADE 4 - SUMMATIVE TEST QUARTER 4 ALL SUBJECTSJoshuaGantuangco2
 
THEORIES OF ORGANIZATION-PUBLIC ADMINISTRATION
THEORIES OF ORGANIZATION-PUBLIC ADMINISTRATIONTHEORIES OF ORGANIZATION-PUBLIC ADMINISTRATION
THEORIES OF ORGANIZATION-PUBLIC ADMINISTRATIONHumphrey A Beña
 
MULTIDISCIPLINRY NATURE OF THE ENVIRONMENTAL STUDIES.pptx
MULTIDISCIPLINRY NATURE OF THE ENVIRONMENTAL STUDIES.pptxMULTIDISCIPLINRY NATURE OF THE ENVIRONMENTAL STUDIES.pptx
MULTIDISCIPLINRY NATURE OF THE ENVIRONMENTAL STUDIES.pptxAnupkumar Sharma
 
Integumentary System SMP B. Pharm Sem I.ppt
Integumentary System SMP B. Pharm Sem I.pptIntegumentary System SMP B. Pharm Sem I.ppt
Integumentary System SMP B. Pharm Sem I.pptshraddhaparab530
 
Keynote by Prof. Wurzer at Nordex about IP-design
Keynote by Prof. Wurzer at Nordex about IP-designKeynote by Prof. Wurzer at Nordex about IP-design
Keynote by Prof. Wurzer at Nordex about IP-designMIPLM
 
TEACHER REFLECTION FORM (NEW SET........).docx
TEACHER REFLECTION FORM (NEW SET........).docxTEACHER REFLECTION FORM (NEW SET........).docx
TEACHER REFLECTION FORM (NEW SET........).docxruthvilladarez
 
Influencing policy (training slides from Fast Track Impact)
Influencing policy (training slides from Fast Track Impact)Influencing policy (training slides from Fast Track Impact)
Influencing policy (training slides from Fast Track Impact)Mark Reed
 
Visit to a blind student's school🧑‍🦯🧑‍🦯(community medicine)
Visit to a blind student's school🧑‍🦯🧑‍🦯(community medicine)Visit to a blind student's school🧑‍🦯🧑‍🦯(community medicine)
Visit to a blind student's school🧑‍🦯🧑‍🦯(community medicine)lakshayb543
 
ClimART Action | eTwinning Project
ClimART Action    |    eTwinning ProjectClimART Action    |    eTwinning Project
ClimART Action | eTwinning Projectjordimapav
 
ICS2208 Lecture6 Notes for SL spaces.pdf
ICS2208 Lecture6 Notes for SL spaces.pdfICS2208 Lecture6 Notes for SL spaces.pdf
ICS2208 Lecture6 Notes for SL spaces.pdfVanessa Camilleri
 
How to do quick user assign in kanban in Odoo 17 ERP
How to do quick user assign in kanban in Odoo 17 ERPHow to do quick user assign in kanban in Odoo 17 ERP
How to do quick user assign in kanban in Odoo 17 ERPCeline George
 
INTRODUCTION TO CATHOLIC CHRISTOLOGY.pptx
INTRODUCTION TO CATHOLIC CHRISTOLOGY.pptxINTRODUCTION TO CATHOLIC CHRISTOLOGY.pptx
INTRODUCTION TO CATHOLIC CHRISTOLOGY.pptxHumphrey A Beña
 
AUDIENCE THEORY -CULTIVATION THEORY - GERBNER.pptx
AUDIENCE THEORY -CULTIVATION THEORY -  GERBNER.pptxAUDIENCE THEORY -CULTIVATION THEORY -  GERBNER.pptx
AUDIENCE THEORY -CULTIVATION THEORY - GERBNER.pptxiammrhaywood
 

Dernier (20)

4.18.24 Movement Legacies, Reflection, and Review.pptx
4.18.24 Movement Legacies, Reflection, and Review.pptx4.18.24 Movement Legacies, Reflection, and Review.pptx
4.18.24 Movement Legacies, Reflection, and Review.pptx
 
Field Attribute Index Feature in Odoo 17
Field Attribute Index Feature in Odoo 17Field Attribute Index Feature in Odoo 17
Field Attribute Index Feature in Odoo 17
 
Q4-PPT-Music9_Lesson-1-Romantic-Opera.pptx
Q4-PPT-Music9_Lesson-1-Romantic-Opera.pptxQ4-PPT-Music9_Lesson-1-Romantic-Opera.pptx
Q4-PPT-Music9_Lesson-1-Romantic-Opera.pptx
 
Textual Evidence in Reading and Writing of SHS
Textual Evidence in Reading and Writing of SHSTextual Evidence in Reading and Writing of SHS
Textual Evidence in Reading and Writing of SHS
 
GRADE 4 - SUMMATIVE TEST QUARTER 4 ALL SUBJECTS
GRADE 4 - SUMMATIVE TEST QUARTER 4 ALL SUBJECTSGRADE 4 - SUMMATIVE TEST QUARTER 4 ALL SUBJECTS
GRADE 4 - SUMMATIVE TEST QUARTER 4 ALL SUBJECTS
 
THEORIES OF ORGANIZATION-PUBLIC ADMINISTRATION
THEORIES OF ORGANIZATION-PUBLIC ADMINISTRATIONTHEORIES OF ORGANIZATION-PUBLIC ADMINISTRATION
THEORIES OF ORGANIZATION-PUBLIC ADMINISTRATION
 
MULTIDISCIPLINRY NATURE OF THE ENVIRONMENTAL STUDIES.pptx
MULTIDISCIPLINRY NATURE OF THE ENVIRONMENTAL STUDIES.pptxMULTIDISCIPLINRY NATURE OF THE ENVIRONMENTAL STUDIES.pptx
MULTIDISCIPLINRY NATURE OF THE ENVIRONMENTAL STUDIES.pptx
 
YOUVE GOT EMAIL_FINALS_EL_DORADO_2024.pptx
YOUVE GOT EMAIL_FINALS_EL_DORADO_2024.pptxYOUVE GOT EMAIL_FINALS_EL_DORADO_2024.pptx
YOUVE GOT EMAIL_FINALS_EL_DORADO_2024.pptx
 
Integumentary System SMP B. Pharm Sem I.ppt
Integumentary System SMP B. Pharm Sem I.pptIntegumentary System SMP B. Pharm Sem I.ppt
Integumentary System SMP B. Pharm Sem I.ppt
 
Keynote by Prof. Wurzer at Nordex about IP-design
Keynote by Prof. Wurzer at Nordex about IP-designKeynote by Prof. Wurzer at Nordex about IP-design
Keynote by Prof. Wurzer at Nordex about IP-design
 
TEACHER REFLECTION FORM (NEW SET........).docx
TEACHER REFLECTION FORM (NEW SET........).docxTEACHER REFLECTION FORM (NEW SET........).docx
TEACHER REFLECTION FORM (NEW SET........).docx
 
Influencing policy (training slides from Fast Track Impact)
Influencing policy (training slides from Fast Track Impact)Influencing policy (training slides from Fast Track Impact)
Influencing policy (training slides from Fast Track Impact)
 
Visit to a blind student's school🧑‍🦯🧑‍🦯(community medicine)
Visit to a blind student's school🧑‍🦯🧑‍🦯(community medicine)Visit to a blind student's school🧑‍🦯🧑‍🦯(community medicine)
Visit to a blind student's school🧑‍🦯🧑‍🦯(community medicine)
 
ClimART Action | eTwinning Project
ClimART Action    |    eTwinning ProjectClimART Action    |    eTwinning Project
ClimART Action | eTwinning Project
 
YOUVE_GOT_EMAIL_PRELIMS_EL_DORADO_2024.pptx
YOUVE_GOT_EMAIL_PRELIMS_EL_DORADO_2024.pptxYOUVE_GOT_EMAIL_PRELIMS_EL_DORADO_2024.pptx
YOUVE_GOT_EMAIL_PRELIMS_EL_DORADO_2024.pptx
 
ICS2208 Lecture6 Notes for SL spaces.pdf
ICS2208 Lecture6 Notes for SL spaces.pdfICS2208 Lecture6 Notes for SL spaces.pdf
ICS2208 Lecture6 Notes for SL spaces.pdf
 
How to do quick user assign in kanban in Odoo 17 ERP
How to do quick user assign in kanban in Odoo 17 ERPHow to do quick user assign in kanban in Odoo 17 ERP
How to do quick user assign in kanban in Odoo 17 ERP
 
INTRODUCTION TO CATHOLIC CHRISTOLOGY.pptx
INTRODUCTION TO CATHOLIC CHRISTOLOGY.pptxINTRODUCTION TO CATHOLIC CHRISTOLOGY.pptx
INTRODUCTION TO CATHOLIC CHRISTOLOGY.pptx
 
AUDIENCE THEORY -CULTIVATION THEORY - GERBNER.pptx
AUDIENCE THEORY -CULTIVATION THEORY -  GERBNER.pptxAUDIENCE THEORY -CULTIVATION THEORY -  GERBNER.pptx
AUDIENCE THEORY -CULTIVATION THEORY - GERBNER.pptx
 
Paradigm shift in nursing research by RS MEHTA
Paradigm shift in nursing research by RS MEHTAParadigm shift in nursing research by RS MEHTA
Paradigm shift in nursing research by RS MEHTA
 

Dementia