Rh Blood Group System

“ RHESUS BLOOD GROUP SYSTEM” PRESENTED BY: KAUSAR FAROOQ, BS MT 3 RD YEAR 6 TH SEMESTER.

Rhesus blood group system ,[object Object],[object Object],[object Object],[object Object]

Rhesus blood group system ,[object Object],[object Object]

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[object Object],[object Object],[object Object],[object Object]

Rh Antigens ,[object Object],[object Object],[object Object],[object Object],[object Object]

Rh Genetics ,[object Object],[object Object],[object Object]

RHD gene RHCE gene Chromosome 1 Proteins

Rh Nomenclature ,[object Object],[object Object],[object Object],[object Object]

Fisher-Race Nomenclature ,[object Object],[object Object],[object Object],[object Object]

Fisher-Race D d C c E e 3 closely linked genes “ d” antigen not produced Produces D antigen Produces C/c antigen Produces E/e antigen

Fisher-Race ,[object Object],[object Object],[object Object],dce DCE dcE Dce dCE DcE dCe DCe

Wiener Nomenclature ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Wiener Theory Single gene at Rh locus rh’ hr’ Rh 0 rh” hr” Rh 0 D rh’ C rh” E hr’ c hr” e 5 Major Rh Factors/Antigens: (longhand version) Produces D antigen on RBC Produces C antigen on RBC

Rosenfield Nomenclature ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Genotype vs. Phenotype ,[object Object],[object Object]

Positive R 2 R 2 cDE/cDE R Positive R 2 r cDE/cde Positive R 1 r CDe/cde Positive R 1 R 2 CDe/cDE Positive R 1 R 1 CDe/CDe Negative rr cde/cde Rh(D) status Symbol Genotype

CcDe R 1 r Cce rr’ CDE R Z R Z cEe rr’’ CdE R 2 R 2 cDe R 0 R 0 cDEe R 2 r ce rr CDe R 1 R 1 CcDEe R 1 R 2 CDE Rh Phenotype

Why is an Rh incompatibility so dangerous when ABO incompatibility is not during pregnancy? ,[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],Rh incompatibility during pregnancy (cont.)

D TESTING: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Importance of the Rh system ,[object Object],[object Object]

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Rh Blood Group System

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