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When to Select Observational Studies as Evidence for Comparative Effectiveness Reviews
1. When To Select Observational Studies as Evidence for Comparative Effectiveness Reviews Prepared for: The Agency for Healthcare Research and Quality (AHRQ) Training Modules for Systematic Reviews Methods Guide www.ahrq.gov
9. Using Observational Studies To Assess Benefits (II) OS = observational study; PICOTS = population, intervention, comparator, outcome, timing, and setting. Consider OSs Always consider: Controlled trials Will OSs provide valid and useful information? Assess whether OSs address the review question Are there gaps in trial evidence? Systematic review question ( including PICOTS) Yes Refocus the review question on gaps Assess the suitability of OSs: Natural history of the disease or exposure Potential biases Confine review to controlled trials No
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16. Using Observational Studies To Assess Benefits OS = observational study; PICOTS = population, intervention, comparator, outcome, timing, and setting. Systematic review question ( including PICOTS) OS = observational study; PICOTS = population, intervention, comparator, outcome, timing, and setting Consider OSs Always consider: Controlled trials Will OSs provide valid and useful information? Assess whether OSs address the review question Are there gaps in trial evidence? Yes Refocus the review question on gaps Assess the suitability of OSs: Natural history of the disease or exposure Potential biases Confine review to controlled trials No
