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My Resume

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My Resume

  1. 1. Adrian Ledesma- Mendoza PhD Student in Biomedical Engineering Team oriented and driven researcher with expertise in tissue engineering and biomaterials fabrication. adrian.ledesma-mendoza@yale.edu (505) 918-9064 55 Prospect Street, New Haven, CT www.linkedin.com/in/adrian-ledesma-mendoza-3480677 Work Experience 06/2014 - 06/2016 Albuquerque, NM Undergraduate Research Assistant The University of New Mexico Development of a human irritation assay using pNIPAM- derived substrates Experience with T3T (fibroblasts), BAEC and Vero cells Surface modification using a custom-made plasma reactor Contact: Prof. Heather Canavan - canavan@unm.edu 07/2015 - 08/2015 Cambridge, MA Undergraduate Summer Intern Harvard University Development of a Heart-On-A-Chip that allows the study of human electrophysiology Experience with neonatal rat ventricular myocytes (NRVM) Surface modification via microcontact printing Contact: Dr. Francesco Pasqualini - fpasqualini@g.harvard.edu Project/Achievements Project/Achievements Education 08/2016 - Present New Haven, CT PhD in Biomedical Engineering Yale University Biomedical Data Analysis Applications of Biomaterials Physiological Systems 08/2011 - 06/2016 Albuquerque, NM GPA: 3.85 B.S. in Chemical Engineering The University of New Mexico Heat, mass and momentum transfer Intro. to Thermodynamics Reaction Kinetics Relevant Courses Relevant Courses Skills & Competences Cell culture Surface modification Cell characterization Matlab modeling ASPEN chemical process modeling Personal Projects Poly(ester-co-amine) (PACE) are polymers that exhibit a large affinity to negatively charge DNA. By employing PACE, we can develop a non-toxic transfection vector for more efficient gene delivery. Pericytes and endothelial cells are key components in the human microvasculature. By studying the effects that stiffness has on these cells, we can have a better understanding of the mechanisms that drive fibrosis progression. Poly(N-isopropyl acrylamide) (pNIPAM) is a thermoresponsive polymer that allows the harvesting of cells sheets. By assembling these cells sheets, we can construct a custom and economical irritation assay to test novel treatments. Curent heart-on-a-chip models don't allow the study of the human electrophysiology. By using a custom-made optical mapping system, we can visualize the electrical propagation of cardiomyocytes in an in vitro model to study various cardiomyopathies. Characterization of Novel Poly(ester-co-amine) Terpolymers for Targeted Gene Delivery (01/2017 - Present) Environmental Effects on Pericyte and Endothelial Cell Structure and Function (08/2016 - 12/2016) Development of a Human Skin Irritation Assay using pNIPAM- derived substrates (06/2014 - 06/2016) Cardiac Propagation on the Heart-On-A-Chip (06/2015 - 08/2015) Awards and Fellowships Worked in the Disease Biophysics Group led by Prof. Kevin Kit Parker NSF Computer Science and Engineering Scholarship (08/2015 - 06/2016) SACNAS Travel Scholarship (10/2015) Harvard University SEAS Research Experience for Undergraduates (REU) Internship (06/2015 - 08/2015) NSF Science, Technology, Engineering, and Mathematics Talent Expansion Program (STEP) (06/2014 - 08/2014) Languages Expert Upper-intermediate Expert Spanish Italian English Interests Tissue Engineering | Drug Delivery | Biomaterials | Disease Modeling