Ce diaporama a bien été signalé.
Nous utilisons votre profil LinkedIn et vos données d’activité pour vous proposer des publicités personnalisées et pertinentes. Vous pouvez changer vos préférences de publicités à tout moment.
AIDS	Drug	Works	on	Monkeys	
Foster	City	firm	records	a	first	
November	17,	1995	
By	BARRY	KAYE	
Times	Staff	Writer	
					F...
Researchers	at	the	National	Institute	of	Allergy	and	Infectious	Diseases,	which	helped	fund	
the	study,	said	early	tests	s...
"Gilead Records a First" against AIDS: Tenofovir (Viread) is 100% Effective in AIDS Model; Interview with Gilead CEO Micha...
Prochain SlideShare
Chargement dans…5
×

"Gilead Records a First" against AIDS: Tenofovir (Viread) is 100% Effective in AIDS Model; Interview with Gilead CEO Michael L Riordan and NIH Officials

13 768 vues

Publié le

Gilead's breakthrough drug candidate PMPA [tenofovir, Viread, constituent of Truvada], shows 100% protection in an NIH-sponsored monkey model of AIDS. Interviewees include Dr Anthony Fauci of NIAID; Dr Michael Riordan, Gilead's founder and CEO; Dr Roberta Black of NIH. “Such complete protection with no toxicity is unprecedented in the monkey model of AIDS,” said Anthony S. Fauci, Director of the National Institute of Allergy and Infectious Diseases. 1995.

Publié dans : Santé & Médecine
  • Follow the link, new dating source: ❤❤❤ http://bit.ly/2F7hN3u ❤❤❤
       Répondre 
    Voulez-vous vraiment ?  Oui  Non
    Votre message apparaîtra ici
  • Sex in your area is here: ♥♥♥ http://bit.ly/2F7hN3u ♥♥♥
       Répondre 
    Voulez-vous vraiment ?  Oui  Non
    Votre message apparaîtra ici

"Gilead Records a First" against AIDS: Tenofovir (Viread) is 100% Effective in AIDS Model; Interview with Gilead CEO Michael L Riordan and NIH Officials

  1. 1. AIDS Drug Works on Monkeys Foster City firm records a first November 17, 1995 By BARRY KAYE Times Staff Writer FOSTER CITY – Researchers at a Foster City biotechnology company reported today that, for the first time, a drug that inhibits the ability of the AIDS virus to replicate itself achieved a 100 percent success rate in monkeys. The early, preclinical studies indicate that a revolutionary compound developed by Gilead Sciences provided protection against the development of simian immunodeficiency virus (SIV) in primates up to 24 hours after they were given large doses of the disease. Gilead conducted the study in conjunction with scientists at the National Institutes of Health and researchers at the University of Washington Primate Center in Seattle. The results appear in this month’s issue of the prestigious Science magazine. “No other drug has ever shown this kind of activity. It is really unbelievable,” said Roberta Black, a microbiologist with the National Institute of Allergy and Infectious Diseases, a division of NIH. Finding a cure for AIDS has been especially difficult because the virus that causes it is constantly changing and mutating. Scientists also know very little about how the disease itself actually works. [Photo Caption: MICHAEL RIORDAN: Gilead CEO says, “It turns off the enzyme the virus uses to replicate itself.”] Gilead’s work involves something known in biotechnology circles as a nucleotide analog, a molecule that binds to a substance called reverse transcriptase. “It turns off the enzyme that the virus uses to replicate itself,” said Michael Riordan, chief executive officer at Gilead. Riordan cautioned that the drug, called PMPA, has not yet been tested in humans, although he said the disease in monkeys is very similar to the HIV virus. There is no known cure for AIDS, which attacks the human immune system and is almost always fatal.
  2. 2. Researchers at the National Institute of Allergy and Infectious Diseases, which helped fund the study, said early tests show that the Gilead drug blocked all traces of the disease in 25 macaque monkeys more than one year after the experiment began. “It sounds almost too good to be true,” said Dr. Marta Marthas, a virologist at the University of California at Davis’ Regional Primate Research Center. But she added, “You can’t argue with that result.” Dr. Ashley Haase, an expert on lentiviruses, the virus family that includes HIV and SIV (simian), said he was “surprised and pleased” by the finding. He added that the study was carefully done and that it was “if anything, more difficult” to protect against SIV than it was to protect against HIV infections. NIH’s Black, who was on work furlough because of the federal budget impasse, said a tremendous amount of additional research still needs to be completed. Further tests are needed, for example, to determine how well monkeys tolerate high doses of the drug. “Monkeys are not human beings,” she said. “Although it is an excellent model for evaluating drugs, it is still a model.” But among the encouraging benefits of the Gilead compound is that, in achieving a 100 percent success rate, there were no additional complications. “Such complete protection with no toxicity is unprecedented in the monkey model of AIDS,” said Anthony S. Fauci, director of infectious diseases at NIH. # # #

×