The document discusses the future of brain health and cognitive technologies. It describes 10 emerging brain technologies including wearables to monitor and enhance focus, meditation, and self-regulation. It also discusses electrical and magnetic brain stimulation, virtual reality treatments, brain-computer interfaces, and neuromonitoring technologies. Finally, it discusses how big data and machine learning can enhance diagnostics and treatments for various brain conditions like seizures, ALS, and more. Overall, the technologies described aim to transform brain health by enhancing functions like memory, learning, and skills training through personalized cognitive simulations and interfaces.

1. The Future of Brain Health

2. Sponsors
Welcome to Day 3--Expo Day

3. Anu Acharya,
CEO and Founder
Mapmygenome
The Future of
Brain Health
Anu Acharya
CEO Map My Genome

5. 10 Brain Transformers
As we enter an era of a transforming cerebrals
there will soon be “Mindful” wearables
to concentrate, meditate and self regulate
Did I just see you drop your jawbone at the gate ?
Charge yourself to a calming or energizing state
Enhance memory and you are now feeling great
Your life may soon be in a different motion
With Electrical and magnetic brain stimulation
Not just in games or
bars that you may frequent
You may come across a Virtual Reality treatment,
In conjunction with EEG and/ or tDCS as a sequent
Mental manipulation of memorized objects
enhancing fluid intelligence and those subjects
Emotions and Cognition through those frames
called Cognitive training videogames
When life is hard and you need help
control external devices when you painfully yelp
Monitoring health through EEG and your soul
Use Brain-Computer Interfaces for device control

6. Normal or diseased - you may want to know
soon on the curve you will be able to show
diagnose and treat like never before
using Big Data-enhanced diagnostics and treatments and more
A seizure may come when no one is around
unwanted and without warning sound
ALS patients and more will benefit
Real-time neuromonitoring with robotic aid specialist
Driving a car and you dose off for a bit
Systems employing neural detection tickle to make you sit
They are in the monitor vehicle operator alertness business
Aptly called Neurosensor based vehicle operator systems
The tasks are many and you poor one
EEG signals the company your mental state
And tailor the computing experience estate
via Brain-responsive computing systems that you may hate
Learning across the extended workforce
will no longer be through a regular course
Improving learning and skills at company stations
Through Collaborative cognitive simulations
10 Brain Transformers

7. Why we haven’t figured it all
• Large no of neurons- 85 billion
• Complex Algorithm used by brain

8. Mental Health to Brain Health

9. As we move towards Personalized Medicine

10. There is a case for Brain Health
• 75% of addressable health care costs are related to lifestyle choices.
(1)
• Numerous studies have linked stress to back pain, colorectal cancer,
infectious disease, heart problems, headaches and diabetes. (2)
• 5.9 million children have been diagnosed with Attention Deficit
Disorder (1)
• 1 in 5 Adults take medication everyday for mental health
• Antidepressants and Antipsychotics, together, outsell all other
drug classes
• Massive coverage increases and changing consumer needs
demand change and increased efficiencies (Mental Health Parity,
Affordable Health Act)

11. Past, Present and Future

12. Mapmygenome Portfolio

13. Personalised Products

14. Genetics influence Neurological conditions
Nature, (520) 224-228, 2015

15. SNPs and Neuro Conditions

16. Conditions Covered in Brainmap

17. A sample report

18. Key
Areas
ADHD
Addiction
Depression
Bipolar
disorder
Autism
Alzheimer's
Schizophrenia
Key Areas
Credit: NINDS

19. SNPs and Neurological Conditions
Source: Eupedia

20. Mapmygenome Cognitive Solutions
Invasive
Treatment
Mapmy
Genome
Solutions

21. Integrative Neuroscience Database
Brain Resource database includes > 130,000 data sets from > 15 Clinical Groups
Databases are emerging in neuroscience which will yield both scientific
insights and practical clinical tools for improved diagnosis, targeted
prescription practices, and clinical decision support.
Surveys
Cognition
Imaging
Physiology
Genetics

22. A Technology Enhanced Model of Clinical Practice
Neurocognitive assessments and brain training exercises can be used in
combination to provide personalized assessment and treatment options.
1. Objective & Rapid Assessment of strengths/deficits
2. Treatment decision support & change monitoring
3. Effective screener for ADHD, Depression, Dementia,
TBI
1. Interactive Brain Training
2. Promotes Resilience
3. Remediates cognitive and emotional deficit areas
1. Heart Rate Variability training
2. Personalized Stress Management
3. Adjunctive non-medicative therapy
Assessment
Treatment
Training Program
Biofeedback-based
stress management
Neuropsychological
Assessment
Brief Screening
1. Rapid Neurodiagonistic Screener
2. Identifies early risk for brain health condition
3. Broad spectrum screen with high sensitivity

23. WebNeuro - Focus
An online test for cognitive strengths

24. Assess core
cognitive and
emotional
capacities

25. Example:
Key Cognitive
Domains

26. Three Levels of Stress
Positive
Brief increases in heart rate, mild
elevations in stress hormone levels
Tolerable
Temporary stress responses
Toxic
Prolonged activation of stress response
system

27. • MyCalmBeat improves your calmness through slow breathing
• Calculates your personal best breathing rate and trains you by
breathing at that rate

28. • Reduces Stress
• Increases Focus
• Builds Resilience
• Training each day for 10 min, just like regular exercise
• Training before presentations, before going to sleep,
periods of stress

29. Sensitivity Specificity
Markers from
• Sustained Attention
• Impulsivity
• Intrusions
• Inhibition
• Response Variability
88% 91%
Williams LM, Using brain-based cognitive measures to support
clinical decisions in ADHD. Pediatric Neurol. 2010 Feb;42(2):118-26.
WebNeuro-Focus test for ADHD

30. BRISC (Brain Resource brain health screen) includes 15 questions to assess:
• Negative-Positive Bias
• Emotional Resilience
• Social Skills
• Helps identify individuals who have and/or are susceptible to a brain health
impairment.
• Negativity Bias has 85% sensitivity an 84% specificity for identifying risk across a broad
spectrum of disorders.
Williams, Cooper, Wisniewski, Gatt, Koslow,
Kulkarni, Gordon, Rush (2011). Sensitivity,
specificity and predictive power of the “BRISC”, a
cross-sectional study on a brief web screen for
brain health. J Clinical Psychiatry (in review)
BRISC For Brain Health Screening

31. Positive-
Negative
Bias
Emotional
Resilience
Social
Skills
Overall
Brain
Health
Service Provider Action
Example
Longer Term
Action
Example
Good Positive feedback
Compliant, follow at
standard call interval
Below
Averag
e
Validate distress and
reinforce adaptive
coping strategies
‘On the ledge’: flag the user
account, and re-screen
Below
Averag
e
Reinforce adaptive
coping and regulation,
and encourage social
engagement
‘On the ledge’: flag the user
account, and re-screen
Poor
Comprehensive MH
assessment required
‘Over the ledge’: Reach out,
to engage and boost
compliance
1 105 1 107
Positive-Negative
Bias:
Average
1 109
Emotional Resilience: Good Social Skills: Good
1.53
6 5.5 7
4.5
1 1.5
21.5
5.5
3
BRISC Scores & Action Examples

32. Call: 1800-102-4595
www.mapmygenome.in
anu@mapmygenome.in
Couples Planning
A Family
Toddlers and
Teens
Brain Health
Pregnant Women
Chronic
Disease
Sports Fitness Healthy Individuals
Newborn Babies
Know Yourself
Healthy, Smart and Fit

33. Summit is on break.
(we will resume at 9:00am Pacific Time)

34. Sponsors
Welcome to Expo Day
Expo Day Agenda
9-9:30am. The Alzheimer’s Research
and Prevention Foundation
9:45-10:15am. Fit Brains
10:30-11am. Baycrest
11:15-11:45am. Lumosity
12-12:30am. BrainBaseline
12:45-1:15am. The SharpBrains Guide
to Brain Fitness

35. www.alzheimersprevention.org
How Integrative Medicine
Is Solving
the Alzheimer’s Crisis
Dharma Singh Khalsa, M.D.
Clinical Associate Professor
Department of Integrative Medicine
University of New Mexico
School of Medicine

36. Maintain a sharp brain with age
Boomers’ #1 Fear
Getting Alzheimer’s
Boomers’ #1 Goal

37. Staggering Statistics
1. 5.4 Million with AD, $150 B cost/year
2. Millions more with SCD, MCI and multiple risk
factors (CVD, obesity, insomnia, drug abuse,
DM)
3. Women 2x as likely to develop AD in their 60’s
& 2/3 of all patients are women
4. A woman’s lifetime risk for AD is higher than
breast cancer: 1 in 6, vs 1 in 11
5. 10 Million unpaid caregivers

38. What is AD?
Accelerated brain aging leading to cognitive
failure:
1. Plaques and tangles
2. Synapse
3. Mitochondria
4. CBF
All fail, leading to loss of memory and
personality

39. Drug Discovery (Pharma) Elusive
But
Non Pharma Prevention Research is
Compelling

40. Integrative Medicine (non-pharma):
The Four Pillars of Alzheimer’s
Prevention
1. Diet and Brain Specific Nutrients
2. Stress Management
3. Exercise
4. Spiritual Fitness

41. Cost
(0-4)
Benefit
(0-4)
Side
Effects
(0-4)
Ease
(0-4)
Research
(0-4)
PHARMA 4+ 0-1
(elusive)
3-4
(incl
death)
4 2
NON-
PHARMA
1 3 1 1-2 3-4
The New Conversation

42. Stress
Got Your
Nerves
on Edge?
From
ISIS to
Politics

43. Stress Increases Risk Factors for AD
1. Memory Loss
2. Inflammation
3. Heart Disease
4. Insomnia
5. Diabetes
6. Anxiety / Depression
7. Genetic Health
8. Loss of Spiritual Direction

44. Stress Impacts Your Genes & DNA
by
Shortening Telomeres

45. What Can You Do?
Put Your Brain Health First

47. Kirtan Kriya
Reduces
Alzheimer’s
Risk
SAA TAA NAA MAA

48. Kirtan Kriya
Before After
Khalsa, D. Newberg, A: Nuclear Medicine Communications, Sept. 2009

49. Posterior Cingulate Gyrus
Up
Khalsa, D.S., Newberg, A. Jl of Nuclear Med Communication 2009
Preventing Alzheimer’s in 12 Minutes a Day?

50. Pre-Program
Baseline
Post-Program
Baseline
Ant Cingulate
Ant Cingulate
PFC
PFC
Changes in the Anterior Cingulate Gyrus

51. Memory

52. KK Increases Telomerase by 43%
0
0.5
1
1.5
2
2.5
3
3.5
4
Base Week 8
Meditation
Relaxation

53. Newest Aspect Of AD Prevention Research
What is Spiritual Fitness?
1. Acceptance
2. Independence
3. Environmental Mastery
4. Personal Growth
5. Positive Relationships
} Reduction
of Risk
Factors
6. Purpose/ Mission  Mild Cognitive Impairment and
Alzheimer’s Risk

54. How to Move from
Information to Experience

55. Take Kirtan Kriya Home
1. Self-led, 12-minute KK meditation now possible
2. Anyone can practice it
3. Best time to do it is first thing in the morning
4. CD and MP3 available for a $20 donation
5. Includes simple instructions
6. It’s easy, enjoy!
www.alzheimersprevention.org

56. And In The End…
Spirit, Wisdom
and Peace of Mind

57. Conclusion
1. The Four Pillars of Integrative Medicine May
Reduce the Risk of Alzheimer’s
1. The Regular Practice of KK is Now Part of the
Alzheimer’s Prevention Conversation
www.alzheimersprevention.org
Dharma Singh Khalsa, M.D.
drdharma@alzheimersprevention.org

58. Summit is on break.
(we will resume at 9:45am Pacific Time)

59. Fit Brains Research
Big data, health policy, and our responsibilities
Conny Lin, M.Sc. Neuroscience
Research Scientist, Fit Brains by Rosetta Stone
clin@rosettastone.com
Ph.D. Candidate, Neuroscience, University of British Columbia
Science Policy Fellow 2014/15, British Columbia Ministry of Health
Sharp Brains Summit 2015, Nov 19, 2015

60. Portfolio
In House Research
• Data research
• Collaboration with
Rosetta Stone language
products
• Local research
programs
Dissemination
• Conference
presentations
• Publications
• Reports
Research
collaborations
• Clinical trial
• Big data research
• Fit Brains as an
assessment tool for
research programs
Research funding
management
• Grant proposals
• Funding financials

61. Big Data: knowledge translation matters
a health policy case
Health strategic goals:
“90% of methadone prescribers will adhere to optimal
dose guidelines (60-120mg)”
• Research shows that most patients are stable on 60-
120mg
• Only 50-60% of patients are prescribed the optimal
dose for the past 6 years… we need to do better!
• Physicians says that’s not possible. People will die!
What went wrong?

62. Logic& Memory& Attention& Visual& Speed&
Big Data: knowledge translation matters
Fit Brains’ case
Population data

63. Logic& Memory& Attention& Visual& Speed&
Big Data: knowledge translation matters
Fit Brains’ case
Population data
Individual data

64. Logic& Memory& Attention& Visual& Speed&
Population data
Individual data
Big Data: knowledge translation matters
Fit Brains’ case
Policy makers see
Physicians see
Researchers see both

65. Fit Brains Research Agenda
In house research
• Data research
• Collaboration with Rosetta
Stone language products
• Local research programs
Dissemination
• Conference presentations
• Publications
Research collaborations
• Clinical trial: brain imaging
(fMRI)
• Vancouver Institutes of Visual
Analytics

66. User Training Pattern
Users tend to play
at a 24 hour interval
“Shadow shapes” is the most
popular game during this time
frame
Registeredtime
earliest
latest
Zoom in to
examine precise
playing pattern
Training pattern of one game:
“Missing Pieces”
Does a training regime produce
performance improvement?
Examples of in house research:
Data analysis

67. Population
Examples of in house research:
Data analysis
Logic& Memory& Attention& Visual&
Attention& Visual& Speed&

68. Data tells us population trends
Big Data tells us how individuals
differ from the population trends

69. Examples of in house research:
How to be a top tiered player?

70. Examples of in house research:
Practice regime
0 10 20 30 40
0
20
40
60
80
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timelapseday
playN
60
Timefromfirstplayto
thetimeaperson
achieveacertaintier

71. Examples of in house research:
How do A/B differ?
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20
40
60
80
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playN
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thetimeaperson
achieveacertaintier

72. Examples of in house research:
How about 50 yrs olds?
0 5 10 15 20
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50 60s

73. Types of collaboration we are looking for
• Data analytics - Use our data to answer research questions:
– Do people who text while driving perform better at executive function
tasks?
– Can we predict performance in memory tasks from initial performance
and training habit?
• Assessment tools – Use our app as a measurement tool to answer
your research questions
– Do people who bike to work perform better at visual-spatial tasks?
– Do people who held management position perform better at facial
expression recognition tasks?
• Intervention studies – use our product as interventions
– Does using Fit Brains produce functional improvements in elderlies’
brain?
– Does using Fit Brains improve classroom performance?

74. Brain imaging Clinical trial
training
fMRI
no training shame training
MCIHealthy
neuropsychological
assessment
neuropsychological
assessment
fMRI
MCIHealthy MCIHealthy

75. How to get involved
• Submit Letter of Intent (LOI) to clin@rosettastone.com
– Investigator information
– Research proposal
– Fit Brains contribution: data, free app access
– Potential benefit to Rosetta Stone
– Project Financial support
• 2 weeks LOI review
• Project logistics discussion
• Agreements: data privacy, IP, work distribution
• Project start

76. THANK YOU

77. Summit is on break.
(we will resume at 10:30am Pacific Time)

78. To learn more, visit sharpbrains.com