Lecture #31 from the Drug Delivery Foundation's 2010 Oral Drug Delivery Conference: http://www.ddfint.org/previous-events/2017/4/22/odd2010-strategies-for-oral-drug-delivery
2. GI Physiology: Transport Mechanistic
Permeability &Transit
Physical Chemistry: InVivo Dissolution
Solubility/Dissolution
Biopharmaceutical Evaluation: Mechanistic
InVivo-InVitro
Dosage FormTechnology: Optimization of Delivery
IR and MR
Regulatory Advances: Separate BE and BA Science
Essential Standard to Insure Label Claims
8. Unknown localization: HPT1, CAT-1, EAAC1, CNT, CNT2, ENT1, ENT2, SAAT1, NBC2,
NPT4, NAPI-3B, SVCT1-2, FAT
Fig. A. Localization of intestinal membrane transporters and their coupling for nutrients and drug absorption. Arrows indicate
the direction of transport. Dashed arrows indicate the coupling of apical transporters with basolateral transporters. rBAT and
b0,+AT form a complex for functional transporter. HLAT and 4F2hc, hy+ LAT and 4F2hc also form a transporter complex.
Apical membraneIntestinal lumen Basal membrane
rBAT
4F2hc
ATB0
TAUT
b0,+AT
hPepT1
MCT1
MOAT
MDR
IBAT
FATP4
SGLT1
GLUT5 GLUT2
OCT1
OCT3
ILBP
HLAT ?
hy+ LAT ?
?
?
?
?
18. Mechanistic
GI Physiology and Product Dissolution
Focused on Product: BE and labeling
Dissolution Methodology and BCS InVivo
Relevance
Mechanistic ADME: BCS and BDDCS