Ce diaporama a bien été signalé.
Le téléchargement de votre SlideShare est en cours. ×

Amino Acids.pptx

Publicité
Publicité
Publicité
Publicité
Publicité
Publicité
Publicité
Publicité
Publicité
Publicité
Publicité
Publicité
Prochain SlideShare
Amino Acids.pdf
Amino Acids.pdf
Chargement dans…3
×

Consultez-les par la suite

1 sur 45 Publicité

Amino Acids.pptx

Télécharger pour lire hors ligne

Study the biochemical aspects of nutrients, their digestion, absorption, metabolism and inter-relationship and to learn about the energy and its pathways.

Study the biochemical aspects of nutrients, their digestion, absorption, metabolism and inter-relationship and to learn about the energy and its pathways.

Publicité
Publicité

Plus De Contenu Connexe

Similaire à Amino Acids.pptx (20)

Plus récents (20)

Publicité

Amino Acids.pptx

  1. 1. Amino Acids Biochemistry Free For All
  2. 2. Part 1 - Amino Acids Structure and Chemistry • Building Blocks of Proteins • Essential Amino Acids • Basic Structure • Stereochemistry • Side Chain Chemistry • Properties • Ionization • Bonding
  3. 3. Amino Acids & Proteins • Workhorses of cell – Catalysis – Signaling – Structure – Energy/Gradient Generation • Proteins comprised of 20-21 amino acids
  4. 4. Amino Acids Essential Amino Acids
  5. 5. Basics of Structure Elements Alpha Amino Acids Differences in R Groups Alpha Carboxyl Alpha Carbon Alpha Amine
  6. 6. Basics of Structure Elements Alpha Amino Acids Differences in R Groups Examples Alpha Carboxyl Alpha Carbon Alpha Amine Alpha Carbon Alpha Carboxyl Alpha Amine R Asymmetric Center
  7. 7. Basics of Structure Elements Alpha Amino Acids Differences in R Groups Examples Alpha Carboxyl Alpha Carbon Alpha Amine R 18 Alpha Amine Alpha Carbon Alpha Carboxyl Asymmetric Center
  8. 8. Amino Acids D and L Isomers Stereochemistry Almost all biological amino acids are in the L-configuration
  9. 9. Categorizing Amino Acids Non-Polar Carboxyl Amine Aromatic Hydroxyl Other Alanine Aspartic Acid Arginine Phenylalanine Serine Asparagine Glycine Glutamic Acid Histidine Tryptophan Threonine Cysteine Isoleucine Lysine Tyrosine Tyrosine Glutamine Leucine Selenocysteine Methionine Pyrrolysine Proline Valine
  10. 10. Ionizable R-groups Name Charged R-group Approximate R-group pKa Aspartic Acid Glutamic Acid -COO- -COO- 4.1 4.1 Lysine Arginine Histidine -NH3 + =NH2 + =-NH+ 10.5 12.5 6.0 Cysteine -S- 8.2 Tyrosine -O- 10.5
  11. 11. Amino Acids Aromatic R-Groups Tyrosine Phenylalanine Tryptophan Alpha Carboxyl Alpha Carbon Alpha Amine
  12. 12. Amino Acids Aromatic R-Groups Tyrosine Phenylalanine Tryptophan R R R
  13. 13. Amino Acids Aromatic R-Groups Charges at Physiological pH Tyrosine Phenylalanine Tryptophan R R R Ionizes at high pH
  14. 14. Amino Acids Aliphatic R-Groups Leucine Proline Alanine Glycine Isoleucine Valine Methionine H
  15. 15. Amino Acids Aliphatic R-Groups Leucine Proline Alanine Glycine Isoleucine Valine Methionine H
  16. 16. Amino Acids Aliphatic R-Groups Charges at Physiological pH
  17. 17. Amino Acids R-Group Carboxyls Aspartic Acid Glutamic Acid
  18. 18. Amino Acids R-Group Carboxyls Aspartic Acid Glutamic Acid R R
  19. 19. Amino Acids R-Group Carboxyls Charges at physiological pH Aspartic Acid Glutamic Acid R R
  20. 20. Amino Acids Hydroxyl R-Groups Serine Threonine Tyrosine
  21. 21. Amino Acids Hydroxyl R-Groups Serine Threonine Tyrosine
  22. 22. Amino Acids Hydroxyl R-Groups Charges at Physiological pH Serine Threonine Tyrosine Ionizes at high pH
  23. 23. Amino Acids Sulfhydryl R-Group Cysteine
  24. 24. Amino Acids Sulfhydryl R-Group Cysteine Ionizes at about pH = 8 +
  25. 25. Amino Acids Carboxamide R-Groups Asparagine Glutamine
  26. 26. Amino Acids Carboxamide R-Groups Asparagine Glutamine
  27. 27. Amino Acids Carboxamide R-Groups Asparagine Glutamine
  28. 28. Amino Acids Ionizable Amine R-Groups Lysine Arginine Histidine
  29. 29. Amino Acids Ionizable Amine R-Groups Lysine Arginine Histidine
  30. 30. Amino Acids Ionizable Amine R-Groups Charges at Physiological pH Lysine Arginine Histidine
  31. 31. Rare Amino Acids
  32. 32. Non-Protein Amino Acids Carnitine Also - Citrulline, Ornithine, others
  33. 33. Amino Acids Ionization
  34. 34. Amino Acids Ionization -by pKa Values
  35. 35. Amino Acids Ionization -by pKa Values
  36. 36. Ionization -by pKa Values Amino Acids
  37. 37. Amino Acids Ion Locations in Titration
  38. 38. Amino Acids Ionization -by pKa Values
  39. 39. Amino Acids Ionization -by pKa Values
  40. 40. Amino Acids Ionization -by pKa Values Charge = -2
  41. 41. Ionization Changes Charges Within Proteins Changes in Charge Change Activities
  42. 42. Post-translational Modifications
  43. 43. Phosphorylated Amino Acids
  44. 44. Breakdown of Amino Acids
  45. 45. Peptide Bond Formation

×