Infectious diseases

1. Infectious Diseases
Dr. Imtiaz Ahmad Qureshi
BSc, MBBS, FCPS
Assistant Professor of Pathology
Rabigh Medical College- KAU

2. Practical -1
Tuberculosis

3. Primary Pulmonary Tuberculosis
Ghon complex:
• The gray-white
parenchymal focus
under the pleura in the
lower part of upper lobe
• Hilar lymph nodes with
caseation are seen on
the left

4. Granuloma with Langhans type of multinucleated giant
Cell

5. Non-Caseating Granuloma

6. Caseating Granulomas

7. Tuberculous Bacilli
Bacilli appear as red rods with Ziehl-Neelsen stain

8. Secondary Pulmonary Tuberculosis.
• Upper parts of both
lungs shows gray-white
areas of caseation and
multiple areas of
softening and
cavitations

9. Secondary Pulmonary Tuberculosis
• Apex of lung shows
cavitation and necrosis

10. Tuberculous Lymphadenitis
Cut surface of the enlarged lymph node shows areas
of cheesy white caseous necrosis

11. Practical-2
Leprosy

12. Tuberculoid Leprosy
• This granuloma is
seen around a
peripheral nerve in
the dermis
• The lepra bacilli
grow best just
below body
temperature,
preferring the
cooler skin and
peripheral nerves

13. Lapromatous Leprosy
• Lepromatous
form of the
disease is seen in
the skin biopsy
which shows
macrophages
filled with short,
thin, red acid-fast
bacilli after
Modified Z-N
stain

14. Hypopigmented lesions

15. Loss of Eyebrows and Eyelashes

16. Lapromatous Leprosy-Aseptic Necrosis

17. Practical-3
Syphilis

18. Primary Chancre of Syphilis
3/4/2018

19. Tertially syphilis
Gumma
3/4/2018

20. Condyloma lata - Secondary syphilis

21. Rash of secondary syphilis involving palms and feet

22. Secondary Syphilis- Papules

23. Tertiary Syphilis
• The odd clefting
divides the liver into
large nodules with
smooth surfaces is
called hepar lobatum
classically, seen in
tertiary syphilis
• The consequence can
be similar to cirrhosis,
with portal
hypertension

24. Practical-4
Fungal infections

25. Candida infection

26. Candida albicans
GMS positive PAS positive

27. Aspergillus Septate hyphae

28. Invasive aspergillosis of the lung

29. 29
Mucormycosis
Non-Septate hyphae

30. Medura Foot

31. Microscopy
Eumycetoma Actinomycosis
3/4/2018
Fungal stain Gram Positive

32. Practical-5 Parasitic diseases
A- Shistosomiasis
B- Hydatid cyst
C-Amebiasis

33. Schistosoma haematobium
U. bladder shows numerous calcified eggs
and extensive scarring

34. Echinococcus granulosum
Hydatid Cyst

35. Gross Morphology Hydatid Cyst

36. Microscopic features of Hydatid Cyst wall and Scolices

37. Amebic Typhilitis
Flask shaped ulcer
in cecum due to Entameba
histolytica infection

38. Amebic Trophozoite
under high power, some
of the Amebic
Trophozoite form shows
ingested red blood cells
3/4/2018

39. References
• Robbins Basic Pathology 9th edition
• Webpath
• Image Gallery - University of Washington
depts.washington.edu/handbook/.../index.ht
ml
• Condyloma Lata
www.brooksidepress.org/Products/Military..
• USMLE Pathology Slides - Flask shaped
ulcer in cecum due ...
usmlepathslides.tumblr.com/