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PATHOGENPATHOGEN
The
Perfect Human
Highly
Contagious
Diarrhea
The Norovirus alters
the intestinal lining,
causing cells to dump
fluid, which gets
washed out of the body
along with many, many,
many noroviruses.
http://phenomena.nationalgeographic.com/2013/01/02/the-norovirus-a-study-in-puked-perfection/
each GRAM of
feces contains
around 5 BILLION
noroviruses ready to
INFECT a new host.
http://jid.oxfordjournals.org/content/205/11/1622.full
but it only takes
about 20 VIRUSES to
establish an infection.
http://www.ncbi.nlm.nih.gov/pubmed/21876931
Highly
Contagious
Vomit
Noroviruses hijack
our nervous system to
slow down the passage
of food from the
stomach into the
intestines.
http://www.mdpi.com/1999-4915/2/3/748
when that
STORED FOOD comes
flying out of the mouth,
it provides a vehicle for
noroviruses to SPREAD.
Easily
Spread
Airborne
Noroviruses easily
float through the air
and settle on
surfaces like food,
countertops, sinks or
toilets.
http://jcm.asm.org/content/48/7/2552
Tougher Than
Bear Grylls
Freeze, Cook or Clean
noroviruses survive
both freezing and
heating and resist
many common chemical
disinfectants.
http://phenomena.nationalgeographic.com/2013/01/02/the-norovirus-a-study-in-puked-perfection/
noroviruses
can SURVIVE on
surfaces for up
to 2 WEEKS.
Maybe even years in still water
http://blogs.scientificamerican.com/artful-amoeba/2012/01/17/misery-inducing-norovirus-can-survive-for-months-perhaps-years-in-drinking-water/
http://www.sciencedirect.com/science/article/pii/S0168160505005854
Rapid
Evolution
Limited Immunity
noroviruses are genetically diverse and
evolve rapidly. That means we’ve only
got a few months of immunity, and then
we’re fair game for another brutal bout
of projectile puking and diarrhea.
http://www.ncbi.nlm.nih.gov/pubmed/16343580?dopt=Abstract
What Doesn’t
Kill You...
ModerateVirulence
noroviruses are only moderately virulent
allowing a large pool of potential hosts
to survive...
and be reinfected.
again.
and again.
and again...
Recipe for an Outbreak
1	 car	 dealership
1	 Infected	 toddler
1	 baby	 changing	 station
Several	 Billion	 Noroviruses
2	 big	 packs	 of	 dry	 paper	 towels	 
16	 employees	 (12	 sick)
Ingredients:
http://www.micro-blog.info/2013/07/this-is-what-happens-when-norovirus-sprays-from-a-toddler/
http://www.salahqutaishat.com/1/post/2013/07/the-st-hit-the-fan-at-an-auto-dealer-in-oregon.html
http://www.ncbi.nlm.nih.gov/pubmed/23559462
Recipe for an Outbreak
Directions:
1. Bring	 an	 infected	 toddler	 to	 
car	 dealership	 and	 liberally	 
spray	 baby	 changing	 station	 
with	 feces.	 	 Leave	 the	 
mess	 for	 a	 dealership	 
employees	 to	 cleanup.
Recipe for an Outbreak
Directions:
2. Clean	 up	 the	 baby	 
changing	 station	 using	 only	 
dry	 paper	 towels.	 	 Leave	 
some	 infected	 feces	 (with	 
billions	 of	 noroviruses)	 
visible	 on	 the	 baby	 
changing	 station.	 For	 
additional	 outbreaks	 leave	 
the	 feces	 visible	 for	 weeks.
Recipe for an Outbreak
Directions:
3. Return	 to	 the	 meeting,	 
touch	 surfaces,	 handle	 food	 
and	 infect	 75%	 of	 your	 
co-workers
Treatment
NOTHING!
•antiviral drugs
•vaccine
•time
•plenty of fluids
Dehydration is the most
common complication and
in severe cases can
require IV fluids.
http://www.cdc.gov/norovirus/about/treatment.html
But it is
possible to
PREVENT
Norovirus
outbreaks.
Prevention
The best way to help
prevent norovirus is
to practice proper
hand washing and
general cleanliness.
http://www.cdc.gov/norovirus/preventing-infection.html
WashYour Hands
Prevention
Remove vomit or diarrhea
right away!
Use soapy water to wash
surfaces that contacted
vomit or diarrhea and all
nearby surfaces, such as
door knobs and toilet
handles
http://www.disinfect-for-health.org/wp-content/themes/disinfect/pdfs/NorovirusIncident_8.5x11_Eng_Color.pdf
Clean contaminated
surfaces
Prevention
Rinse thoroughly with
plain water
Wipe dry with paper towels
http://www.epa.gov/oppad001/list_g_norovirus.pdf
Clean contaminated
surfaces
But DON’T STOP here.
Norovirus can survive on
surfaces after cleaning
Prevention
Disinfect surfaces by
applying a chlorine bleach
solution or EPA approved
disinfectant
Disinfect Surfaces
Prevention
Prepare a chlorine bleach
solution (or disinfectant)
Allow disinfectant to air
dry for surfaces unlikely
to have food or mouth
contact
Rinse all surfaces
intended for food or mouth
contact with plain water
before use
Disinfect Surfaces
Cleaning and
Disinfection Resources
• Restroom Cleaning Procedures
• EPA Approved Disinfectants
• Baby Changing Station Sanitation
Instructions
• Industry Cleaning Tips
Norovirus BREAKS BAD
millions of times each year
More Common
Than the
Cold?
No. But...
Norovirus is the most
common cause of acute
gastroenteritis in
the United States
https://www.osha.gov/Publications/norovirus-factsheet.pdf
So What’s
the Big
Deal?
It’s expensive!
•21 million illnesses
•2 million outpatient visits
•400,000 emergency department visits
•70,000 hospitalizations
•800 deaths each year
http://www.cdc.gov/norovirus/php/illness-outbreaks.html
It’s more
common
than you
think
A.G.E.
(acute gastroenteritis)
•179 million episodes occur annually
•50% caused by norovirus
•NORS started tracking in 2009
•Most illnesses are not tied to a
reported outbreak (1/3000)
http://wwwnc.cdc.gov/eid/article/19/8/13-0482_article.htm
The first identified
OUTBREAK was in 1968
at Bronson Elementary
school in NORWALK Ohio
http://en.wikipedia.org/wiki/Norovirus
That’s why it’s sometimes
called NORWALK VIRUS.
Norwalk virus is the species, where as norovirus is
the genus (but there’s only one known species in
the genus anyways).
Discovery
The 1968 outbreak of
gastroenteritis at Bronson
Elementary school in
Norwalk Ohio prompted a
lot of scientific study.
But it wasn’t until 1972
that Dr Albert Kapikian
discovered the virus
behind that outbreak.
http://www.niaid.nih.gov/labsandresources/labs/aboutlabs/lid/epidemiologysection/Pages/kapikian.aspx
Dr.Albert Kapikian
What Can
YOU do?
Report unclean
conditions
•Report unclean restrooms to management
•Wash your hands regularly
•Stay home when you’re sick (really, no need to
be a hero, let someone else finish those TPS reports.)
http://www.salahqutaishat.com/
Photo Attributes
• Photo Credit: <a href="http://www.flickr.com/photos/28634332@N05/5654415647/">NASA's Marshall Space Flight Center</a> via <a href="http://compfight.com">Compfight</a> <a href="http://
creativecommons.org/licenses/by-nc/2.0/">cc</a>
• Photo Credit: <a href="http://www.flickr.com/photos/47353092@N00/8102307987/">AJC1</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-sa/
2.0/">cc</a>
• Photo Credit: <a href="http://www.flickr.com/photos/24315793@N02/3010888802/">Reggie Rachuba</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/
by-nc-nd/2.0/">cc</a>
• Photo Credit: <a href="http://www.flickr.com/photos/70591690@N00/2693551009/">ZeroOne</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-sa/
2.0/">cc</a>
• Photo Credit: <a href="http://www.flickr.com/photos/34864797@N07/3473249591/">parkydoodles</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-
nc-sa/2.0/">cc</a>
• Photo Credit: <a href="http://www.flickr.com/photos/10819063@N06/3654276952/">tbSMITH</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-nc-nd/
2.0/">cc</a>
• Photo Credit: <a href="http://www.flickr.com/photos/37129284@N02/5093910979/">greg westfall.</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by/
2.0/">cc</a>
• Photo Credit: <a href="http://www.flickr.com/photos/35703177@N00/3095149875/">The U.S. Army</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by/
2.0/">cc</a>
• Photo Credit: <a href="http://www.flickr.com/photos/93247490@N00/441858611/">Mark Lobo .</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-nc-
nd/2.0/">cc</a>
• Photo Credit: <a href="http://www.flickr.com/photos/95492938@N00/81671961/">Kaptain Kobold</a> via <a href="http://co
• mpfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-nc-sa/2.0/">cc</a>
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2.0/">cc</a>
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The Perfect Human Pathogen

  • 2. Highly Contagious Diarrhea The Norovirus alters the intestinal lining, causing cells to dump fluid, which gets washed out of the body along with many, many, many noroviruses. http://phenomena.nationalgeographic.com/2013/01/02/the-norovirus-a-study-in-puked-perfection/
  • 3. each GRAM of feces contains around 5 BILLION noroviruses ready to INFECT a new host. http://jid.oxfordjournals.org/content/205/11/1622.full
  • 4. but it only takes about 20 VIRUSES to establish an infection. http://www.ncbi.nlm.nih.gov/pubmed/21876931
  • 5. Highly Contagious Vomit Noroviruses hijack our nervous system to slow down the passage of food from the stomach into the intestines. http://www.mdpi.com/1999-4915/2/3/748
  • 6. when that STORED FOOD comes flying out of the mouth, it provides a vehicle for noroviruses to SPREAD.
  • 7. Easily Spread Airborne Noroviruses easily float through the air and settle on surfaces like food, countertops, sinks or toilets. http://jcm.asm.org/content/48/7/2552
  • 8. Tougher Than Bear Grylls Freeze, Cook or Clean noroviruses survive both freezing and heating and resist many common chemical disinfectants. http://phenomena.nationalgeographic.com/2013/01/02/the-norovirus-a-study-in-puked-perfection/
  • 9. noroviruses can SURVIVE on surfaces for up to 2 WEEKS. Maybe even years in still water http://blogs.scientificamerican.com/artful-amoeba/2012/01/17/misery-inducing-norovirus-can-survive-for-months-perhaps-years-in-drinking-water/ http://www.sciencedirect.com/science/article/pii/S0168160505005854
  • 10. Rapid Evolution Limited Immunity noroviruses are genetically diverse and evolve rapidly. That means we’ve only got a few months of immunity, and then we’re fair game for another brutal bout of projectile puking and diarrhea. http://www.ncbi.nlm.nih.gov/pubmed/16343580?dopt=Abstract
  • 11. What Doesn’t Kill You... ModerateVirulence noroviruses are only moderately virulent allowing a large pool of potential hosts to survive... and be reinfected. again. and again. and again...
  • 12. Recipe for an Outbreak 1 car dealership 1 Infected toddler 1 baby changing station Several Billion Noroviruses 2 big packs of dry paper towels 16 employees (12 sick) Ingredients: http://www.micro-blog.info/2013/07/this-is-what-happens-when-norovirus-sprays-from-a-toddler/ http://www.salahqutaishat.com/1/post/2013/07/the-st-hit-the-fan-at-an-auto-dealer-in-oregon.html http://www.ncbi.nlm.nih.gov/pubmed/23559462
  • 13. Recipe for an Outbreak Directions: 1. Bring an infected toddler to car dealership and liberally spray baby changing station with feces. Leave the mess for a dealership employees to cleanup.
  • 14. Recipe for an Outbreak Directions: 2. Clean up the baby changing station using only dry paper towels. Leave some infected feces (with billions of noroviruses) visible on the baby changing station. For additional outbreaks leave the feces visible for weeks.
  • 15. Recipe for an Outbreak Directions: 3. Return to the meeting, touch surfaces, handle food and infect 75% of your co-workers
  • 16. Treatment NOTHING! •antiviral drugs •vaccine •time •plenty of fluids Dehydration is the most common complication and in severe cases can require IV fluids. http://www.cdc.gov/norovirus/about/treatment.html
  • 17. But it is possible to PREVENT Norovirus outbreaks.
  • 18. Prevention The best way to help prevent norovirus is to practice proper hand washing and general cleanliness. http://www.cdc.gov/norovirus/preventing-infection.html WashYour Hands
  • 19. Prevention Remove vomit or diarrhea right away! Use soapy water to wash surfaces that contacted vomit or diarrhea and all nearby surfaces, such as door knobs and toilet handles http://www.disinfect-for-health.org/wp-content/themes/disinfect/pdfs/NorovirusIncident_8.5x11_Eng_Color.pdf Clean contaminated surfaces
  • 20. Prevention Rinse thoroughly with plain water Wipe dry with paper towels http://www.epa.gov/oppad001/list_g_norovirus.pdf Clean contaminated surfaces
  • 21. But DON’T STOP here. Norovirus can survive on surfaces after cleaning
  • 22. Prevention Disinfect surfaces by applying a chlorine bleach solution or EPA approved disinfectant Disinfect Surfaces
  • 23. Prevention Prepare a chlorine bleach solution (or disinfectant) Allow disinfectant to air dry for surfaces unlikely to have food or mouth contact Rinse all surfaces intended for food or mouth contact with plain water before use Disinfect Surfaces
  • 24. Cleaning and Disinfection Resources • Restroom Cleaning Procedures • EPA Approved Disinfectants • Baby Changing Station Sanitation Instructions • Industry Cleaning Tips
  • 25. Norovirus BREAKS BAD millions of times each year
  • 26. More Common Than the Cold? No. But... Norovirus is the most common cause of acute gastroenteritis in the United States https://www.osha.gov/Publications/norovirus-factsheet.pdf
  • 27. So What’s the Big Deal? It’s expensive! •21 million illnesses •2 million outpatient visits •400,000 emergency department visits •70,000 hospitalizations •800 deaths each year http://www.cdc.gov/norovirus/php/illness-outbreaks.html
  • 28. It’s more common than you think A.G.E. (acute gastroenteritis) •179 million episodes occur annually •50% caused by norovirus •NORS started tracking in 2009 •Most illnesses are not tied to a reported outbreak (1/3000) http://wwwnc.cdc.gov/eid/article/19/8/13-0482_article.htm
  • 29. The first identified OUTBREAK was in 1968 at Bronson Elementary school in NORWALK Ohio http://en.wikipedia.org/wiki/Norovirus
  • 30. That’s why it’s sometimes called NORWALK VIRUS. Norwalk virus is the species, where as norovirus is the genus (but there’s only one known species in the genus anyways).
  • 31. Discovery The 1968 outbreak of gastroenteritis at Bronson Elementary school in Norwalk Ohio prompted a lot of scientific study. But it wasn’t until 1972 that Dr Albert Kapikian discovered the virus behind that outbreak. http://www.niaid.nih.gov/labsandresources/labs/aboutlabs/lid/epidemiologysection/Pages/kapikian.aspx Dr.Albert Kapikian
  • 32. What Can YOU do? Report unclean conditions •Report unclean restrooms to management •Wash your hands regularly •Stay home when you’re sick (really, no need to be a hero, let someone else finish those TPS reports.) http://www.salahqutaishat.com/
  • 33. Photo Attributes • Photo Credit: <a href="http://www.flickr.com/photos/28634332@N05/5654415647/">NASA's Marshall Space Flight Center</a> via <a href="http://compfight.com">Compfight</a> <a href="http:// creativecommons.org/licenses/by-nc/2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/47353092@N00/8102307987/">AJC1</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-sa/ 2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/24315793@N02/3010888802/">Reggie Rachuba</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/ by-nc-nd/2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/70591690@N00/2693551009/">ZeroOne</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-sa/ 2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/34864797@N07/3473249591/">parkydoodles</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by- nc-sa/2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/10819063@N06/3654276952/">tbSMITH</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-nc-nd/ 2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/37129284@N02/5093910979/">greg westfall.</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by/ 2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/35703177@N00/3095149875/">The U.S. Army</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by/ 2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/93247490@N00/441858611/">Mark Lobo .</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-nc- nd/2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/95492938@N00/81671961/">Kaptain Kobold</a> via <a href="http://co • mpfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-nc-sa/2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/34838158@N00/3370167184/">alexkess</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-nc-nd/ 2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/34838158@N00/3370167184/">alexkess</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by-nc-nd/ 2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/93587218@N00/2452029695/">Mel B.</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by/ 2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/98005720@N00/4100788909/">Amarand Agasi</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by- nc-sa/2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/45940879@N04/5421517469/">Kalexanderson</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by- nc-sa/2.0/">cc</a> • Photo Credit: <a href="http://www.flickr.com/photos/99479626@N00/3492602261/">Eneas</a> via <a href="http://compfight.com">Compfight</a> <a href="http://creativecommons.org/licenses/by/ 2.0/">cc</a>