Conference on Receptor Tyrosine kinase quantiftation by Ms2plex by X. Morge - Oncotrans 2017

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These tools are very useful for either a better comprehension of cancer physiopathology or even cell lines qualification. They can also be The tool to define the therapeutical protocol.

Health & Medicine

Réf.
Generalpresentation-Confidential
1 - 06/02/2017
Receptor tyrosine kinase
identification/quantification
using LC/MSMS
MS2plex applied to
oncogenic recpetors

Réf.
Generalpresentation-Confidential
2 - 06/02/2017
Rational for proteomic quantification (MS2plex®) in
cancer management
 Tumor heterogeneity is now well demonstrated and a
critical issue (between/within patients)
 This impairs the rational selection a therapeutic
strategy
 Identification of subtypes is achieved by Molecular
Biology (not directly linked to protein
expression/function) and through antibodies (with
specificity and throughput issues)
 MS2plex®, new alternative to allow the measurement
of up to 21 different markers in a single run

Réf.
Generalpresentation-Confidential
3 - 06/02/2017
Proteomic quantification (MS2plex®*) principle
*Exclusive Technologie developed by
Terasaki Tetsuya, Tohoku University,
Sendai, Japan

$Réf. Generalpresentation-Confidential 4 - 06/02/2017  Membrane proteins in plasma membrane fraction expression levels of tumor tissues useful for an appropriate drug selection for the individual treatment of brain tumor  Patient having an anaplastic meningioma with metastatic lesion remaining after surgery & radiotherapy * Platelet derived growth factor receptor * Biomarker applications: identifying accurate target receptor (clinical study case) NeuropathologyandAppliedNeurobiology(2012),38,105–110$

Réf.
Generalpresentation-Confidential
5 - 06/02/2017
Biomarker applications: identifying accurate target
receptor (clinical study case)
 Sunitinib (marketed as Sutent), an oral SMI of multi-
targeted receptor tyrosine kinase approved for the
treatment of renal cell carcinoma used as adjuvant
chemotherapy
NeuropathologyandAppliedNeurobiology(2012),38,105–110

Réf.
Generalpresentation-Confidential
6 - 06/02/2017
Solutions
 Central lab to quantify TKR & other membrane
protein in your samples
 Supplyer of kit ready-to-use
 Prerequisits:
 mg of biopsis (frozen samples)
 Sensitivity in fmol range

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