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Vitamin D
Spikes in testing and miracle cures
PFC Eaker
What is Vitamin D?
• Fat Soluble Vitamin
• Found in food
• Absorbed through sunlight exposure
• Converted to hormone form ...
Two Major Forms of Vitamin D
• Vitamin D2, ergocalciferol
• Vitamin D3, cholecalciferol
Other Forms of Vitamin D
• Vitamin D1: molecular compound of
ergocalciferol with lumisterol, 1:1
• Vitamin D4: 22-dihydroe...
What are the sources?
• Cod Liver Oil, 1 Tbs: 1,360 IU
• Salmon, cooked, 3 1/2 oz: 360 IU
• Mackerel, cooked, 3 1/2 oz: 34...
Exposure to sunlight
• Important source of vitamin D
• Season, latitude, time of day
What does Vitamin D do?
• Maintain normal blood levels of Calcium and
Phosphorus
• Aids in absorption of calcium
• Promote...
Role in immunomodulation
• Binds to nuclear Vitamin D receptors (VDR)
• Immune enhancing and immunosuppressive
effects
• I...
How much Vitamin D do we need?
• Ages 19-50: 200 International Units (IU)
• Ages 51-69: 400 IU
• Age 70 and older: 600 IU
When can vitamin D deficiency occur?
• Rickets
• Osteomalacia
Rickets/Osteomalacia
Who may need extra vitamin D to
prevent a deficiency?
• Older Americans (greater than age 50)
• individuals with limited s...
What is the health risk of too much
vitamin D?
• nausea
• vomiting
• poor appetite
• constipation
• weakness
• weight loss
When is it ordered?
• 25 OH Vitamin D test
• 1,25 di OH Vitamin D test
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
Testing
What does the test result mean?
• 25 OH Vitamin D test
Low blood levels = not getting enough exposure
to sunlight
problem ...
Spike in Vitamin D testing
• ABC NEWS - NEW YORK, NY, USA
“Sunshine Vitamin May Cut Death Risk”
• BBC NEWS - UNITED KINGDO...
Current Research
• Cancers
• Heart Disease
• Stroke
• Diabetes
• Depression
• Muscle Weakness
• Birth Defects
• Obesity
Role in cancer prevention and
recovery
• Calcitriol – Induces
death of cancer cells
• Regulates Cell growth,
Differentiati...
Vitamin D and Obesity
• Seasons
• Altitude
• Calcium
• Link between other
diseases
• Treatable
Vitamin D and Diabetes
• Low serum levels at greater risk
• Lack of Vitamin D interferes with insulin secretion
Vitamin D and depression
• SAD
• 130 patients
• 600 or 4,000 IU supplements
• Re-evaluated 1 year later
Conclusion
• Vitamin D – The wonder drug?
• LabCorp – Testing volume doubled every ear for
the past four years
• Quest Dia...
Questions?
Vitamin d presentation
Vitamin d presentation
Vitamin d presentation
Vitamin d presentation
Vitamin d presentation
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Vitamin d presentation

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Vitamin d presentation

  1. 1. Vitamin D Spikes in testing and miracle cures PFC Eaker
  2. 2. What is Vitamin D? • Fat Soluble Vitamin • Found in food • Absorbed through sunlight exposure • Converted to hormone form through liver and kidney
  3. 3. Two Major Forms of Vitamin D • Vitamin D2, ergocalciferol • Vitamin D3, cholecalciferol
  4. 4. Other Forms of Vitamin D • Vitamin D1: molecular compound of ergocalciferol with lumisterol, 1:1 • Vitamin D4: 22-dihydroergocalciferol • Vitamin D5: sitocalciferol (made from 7- dehydrosisterol)
  5. 5. What are the sources? • Cod Liver Oil, 1 Tbs: 1,360 IU • Salmon, cooked, 3 1/2 oz: 360 IU • Mackerel, cooked, 3 1/2 oz: 345 IU • Sardines, canned in oil, drained, 3 1/2 oz: 270 IU • Milk, nonfat, reduced fat, and whole, vitamin D fortified, 1 c: 98 IU • Margarine, fortified, 1 Tbs: 60 IU • Pudding, 1/2 c prepared from mix and made with vitamin D fortified milk: 50 IU • Dry cereal, Vitamin D fortified w/10% of the recommended daily value, 3/4 c: 40-50 IU (other cereals may be fortified with more or less vitamin D) • Liver, beef, cooked, 3 1/2 oz: 30 IU • Egg, 1 whole (vitamin D is present in the yolk): 25 IU
  6. 6. Exposure to sunlight • Important source of vitamin D • Season, latitude, time of day
  7. 7. What does Vitamin D do? • Maintain normal blood levels of Calcium and Phosphorus • Aids in absorption of calcium • Promotes bone mineralization • Prevents rickets in children and Osteomalacia in adults
  8. 8. Role in immunomodulation • Binds to nuclear Vitamin D receptors (VDR) • Immune enhancing and immunosuppressive effects • Increase activity of NKCs • Increased production of cathelicidin • Therepeutic Clinical Applications
  9. 9. How much Vitamin D do we need? • Ages 19-50: 200 International Units (IU) • Ages 51-69: 400 IU • Age 70 and older: 600 IU
  10. 10. When can vitamin D deficiency occur? • Rickets • Osteomalacia
  11. 11. Rickets/Osteomalacia
  12. 12. Who may need extra vitamin D to prevent a deficiency? • Older Americans (greater than age 50) • individuals with limited sun exposure • occupations that prevent exposure to sunlight • reduced ability to absorb dietary fat • exclusively breast-fed infants
  13. 13. What is the health risk of too much vitamin D? • nausea • vomiting • poor appetite • constipation • weakness • weight loss
  14. 14. When is it ordered? • 25 OH Vitamin D test • 1,25 di OH Vitamin D test
  15. 15. Testing
  16. 16. Testing
  17. 17. Testing
  18. 18. Testing
  19. 19. Testing
  20. 20. Testing
  21. 21. Testing
  22. 22. Testing
  23. 23. Testing
  24. 24. Testing
  25. 25. Testing
  26. 26. Testing
  27. 27. Testing
  28. 28. Testing
  29. 29. Testing
  30. 30. What does the test result mean? • 25 OH Vitamin D test Low blood levels = not getting enough exposure to sunlight problem with absorption from the intestines High levels = supplementation from vitamin pills or other nutritional supplements • 1,25 di OH Vitamin D test Low levels = kidney disease one of the earliest changes to occur in persons with early kidney failure. High levels = excess parathryoid hormone diseases such as sarcoidosis or some lymphomas, that can make 1,25 di OH Vitamin D outside of the kidneys
  31. 31. Spike in Vitamin D testing • ABC NEWS - NEW YORK, NY, USA “Sunshine Vitamin May Cut Death Risk” • BBC NEWS - UNITED KINGDOM “Pain Linked With Low Vitamin D” • BLOOMBERG.COM “Death May Be Nearer For People Who lack Vitamin D” • BRITTANIA RADIO “Vitamin D Can Heal Tuberculosis?”
  32. 32. Current Research • Cancers • Heart Disease • Stroke • Diabetes • Depression • Muscle Weakness • Birth Defects • Obesity
  33. 33. Role in cancer prevention and recovery • Calcitriol – Induces death of cancer cells • Regulates Cell growth, Differentiation etc. • Daily intake of 1,000IU/day reduces risks
  34. 34. Vitamin D and Obesity • Seasons • Altitude • Calcium • Link between other diseases • Treatable
  35. 35. Vitamin D and Diabetes • Low serum levels at greater risk • Lack of Vitamin D interferes with insulin secretion
  36. 36. Vitamin D and depression • SAD • 130 patients • 600 or 4,000 IU supplements • Re-evaluated 1 year later
  37. 37. Conclusion • Vitamin D – The wonder drug? • LabCorp – Testing volume doubled every ear for the past four years • Quest Diagnostics – Testing volume tripled between May 2006 and May 2008
  38. 38. Questions?

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