various vaccines, cold chain, its storage

1. Presented by
Dr. Reshma Francis
Pharm D

2. Vaccines
*Any preparation intended to produce immunity to a disease
by stimulating the production of antibodies.
*Includes
Live attenuated vaccines
MMR, Rotavirus, Smallpox, Chickenpox,
Yellow fever
Inactivated vaccines
Hep A,Polio, Rabies
Toxoid vaccines
Diphtheria, Tetanus

3. *Cold chain
*The cold chain is the system of
transporting and storing vaccines at
recommended temperature from the point
of manufacturing to the point of use
Manufacturer
Distributor
Vaccine depots
Provider office
Patient
v

4. *Why is cold chain important?
1. Vaccines are
Biological products
Lose potency with time
Degradation is irreversible and gets accelerated if proper storage
conditions are not adhered to. The responsibility not to waste scarce NHS
resources.
2. To reduce wastage from errors.
3. Responsibility of health care providers to assure the effectiveness of
vaccines.
4. Any vaccine that has not been stored at a temperatureof 2-80 C as per its
licensing conditions is no longer a licensed product.

5. Least sensitive
*Vaccine stability
Sensitivity to Heat Sensitivity to Cold
Most sensitive
BCG
Varicella
MMR
Men C
Hep B
DT and/or aP/IPV/HIB
Hep B and combinations
DT and/or aP/IPV/HIB
Influenza
MenC
MMR
*Varicella
*BCG

6. *Light sensitive
Sensitive to strong light, sunlight, UV rays etc.
BCG
MMR
Varicella
Meningococcal C
Conjugate
Most DTaP containing
vaccines
Vaccines should
always be stored in
their original
packaging until point
of use to protect them
from light

7. POINTS TO REMEMBER
*Vaccines must be stored at 2-80 C.
* Temperature must be recorded twice a day.
*Time to time checking and review of expiry dates of
vaccines and rotation of vaccine stock
*During vaccine logistics and supply chain, don’t let
vaccines exposed to temperatures at which they
could lose their potency

8. *Vaccine vial monitor
VVM is a label containing heat sensitive material that
is placed on a vaccine vial to register heat exposure
over time.
VVM