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ROLE OF ANTI CHOLINE ESTERASES IN
ALZHEIMERS DISEASE
SIRISHA. A
POST GRADUATE
DEPT OF PHARMACOLOGY
OVER VIEW
• INTRODUCTION
• DEFINING ALZHEIMERS DISEASE
• PATHOGENESIS
• NEUROCHEMISTRY
• DRUGS USED FOR COGNITIVE SYMPTOMS...
PATHOPHYSIOLOGY
NEUROCHEMISTRY
FEATURES TACRINE DONEPEZIL RIVASTIGMINE GALANTAMINE
ENZYMES
INHIBITED
ACHE, BuCHE ACHE ACHE, BuCHE ACHE
MECHANISM NON
COMP...
THANK U
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role of anti cholinesterases in alzheimers

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alzheimers disease

Publié dans : Santé & Médecine
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role of anti cholinesterases in alzheimers

  1. 1. ROLE OF ANTI CHOLINE ESTERASES IN ALZHEIMERS DISEASE SIRISHA. A POST GRADUATE DEPT OF PHARMACOLOGY
  2. 2. OVER VIEW • INTRODUCTION • DEFINING ALZHEIMERS DISEASE • PATHOGENESIS • NEUROCHEMISTRY • DRUGS USED FOR COGNITIVE SYMPTOMS • ANTI CHOLINE ESTERASES • CONCLUSION
  3. 3. PATHOPHYSIOLOGY
  4. 4. NEUROCHEMISTRY
  5. 5. FEATURES TACRINE DONEPEZIL RIVASTIGMINE GALANTAMINE ENZYMES INHIBITED ACHE, BuCHE ACHE ACHE, BuCHE ACHE MECHANISM NON COMPETITIVE NON COMPETITIVE NON COMPETITIVE COMPETITIVE MAINTENECE DOSE 20 mg QID 10 mg OD 6 mg BD 12 mg BD T1/2 70 Hrs 2Hrs METABOLISM CYP1A2 CYP2D6, CYP3A4 ESTERASES CYP2D6, CYP3A4 FDA APPROVED USES MILD-MOD AD MILD-SEVERE AD MILD-MOD AD, MILD-MOD PD MILD-MOD AD ADVERSE EFFECTS HEPATOCELLUL AR NECROSIS SPECIAL DELIVERY SYSTEMS 9.5 mg/24h (transdermal 16-24 mg/day (extended- release) ANOREXIA, ABNORMAL DREAMS, DIARRHEA, VOMITING, TREMORS, AND MUSCLE CRAMPS
  6. 6. THANK U

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