1. Predicting Clinical and Biochemical Endpoints after Radical Prostatectomy Andrew J. Stephenson, MD FRCSC FACS Director, Urologic Oncology Glickman Urological and Kidney Institute Cleveland Clinic

4. Postoperative Nomogram Kattan et al. J Clin Oncol 1999; Graefen et al. J Clin Oncol 2002; Bianco et al. J Urol 2003 Single surgeon, 996 pts, open RP, 1983-1997, BCR Endpoint: PSA 0.4 ng/mL and rising Bootstrapped c-index: 0.88 Model predictions remarkably robust when applied to diverse external validation populations C-index 0.80-0.83

11. Prostate Cancer-Specific Survival: Gleason Score Analysis Eggener et al. J Urol 2011 Gleason 6 Glsn 3+4 Glsn 4+3 Glsn 8-10 Age < 60 Age 60-69 Age > 69

12. Prostate Cancer-Specific Survival: Pathological Stage Eggener et al. J Urol 2011 Organ- Confined EPE SVI LNI Age < 60 Age 60-69 Age > 69