Zaytseva Ekaterina, Doronina Ludmila, Molchkov Roman, Tokmakova Alla

1. Zaytseva Ekaterina*, Doronina Ludmila,
Molchkov Roman, Tokmakova Alla.

2.  Aim: to evaluate clinical and histological
effects of NPWT compared to standard
wound care in diabetic ulcers
 Methods:
◦ clinical examination
◦ transcutaneous oxygen
monitoring(TcpO2)
◦ ulcer biopsies (stained with
haemotoxylin-eosin)
2
before and after
treatment
Clinical
characteristic
before therapy
Group 1 (n=9)
NPWT (-90-120
mmHg)
Group 2
(n=12)
Standard care
Age, years 55,3±12 59,2±9
HbA1c, % 9,2±1,8 9,0±1,5
Wound area,
cm2
35,8±26 37±25
Wound depth,
cm
4,05±2,79 3,57±1,8
TcpO2, mmHg 33,7±17 32,1±17,8
Histological
features of
wound
biopsies
before
treatment
significant oedema, poorly
organized extracellular matrix,
small amount of fibroblast-like
cells, chronic inflammatory
infiltrate presented mainly
neutrophils and lymphocytes

3. Results in 8±4 days of
treatment
0
20
40
60
before
therapy
after
therapy
3

4. 4
Histologically:
Significant
reduction of
oedema and
inflammatory
cells, presence
of mature
connective
tissue
Day 6
Day
0
Slight
reduction of
oedema, cells
of
inflammatory
infiltrate;
perivascular
oedemaDay 0 Day 8
Clinical condition of wounds after therapy
Day 0
In 9 days of
NPWT
In 12 days of
Standard care
NPWT
Standard
care

5.  NPW-therapy is more
effective in comparison
to standard
 It increases local
perfusion
 NPWT can reduce time
before wound closure
by plastic surgery
5
Zai.kate@gmail.com
Endocrinology Research Centre.
Diabetic foot department
117036 Dm.Ulyanova Street, 11.
Moscow, Russian Federation